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  1. 1441
    por Zambrano, Joelle, Yeh, Elizabeth S.
    Publicado 2016
    “…While breast cancer patients benefit from the use of HER2 inhibitors, many fail therapy and become resistant to treatment, indicating a critical need to prevent treatment failure. …”
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    Autophagy and Apoptotic Crosstalk: Mechanism of Therapeutic Resistance in HER2-Positive Breast Cancer
  2. 1442
    “…Aim. HER2 overexpression has been reported in a minority of urothelial carcinomas, but little is known about HER2 protein expression and gene alterations in plasmacytoid urothelial carcinoma, a rare and aggressive variant. …”
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    HER2 Protein Overexpression and Gene Amplification in Plasmacytoid Urothelial Carcinoma of the Urinary Bladder
  3. 1443
    “…Study group included 270 HER2-positive advanced breast cancer patients treated with lapatinib and capecitabine. …”
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    Immunohistochemical prediction of lapatinib efficacy in advanced HER2-positive breast cancer patients
  4. 1444
    “…The introduction of trastuzumab therapy markedly improved the poor prognosis associated with HER2-amplified breast cancers. Despite this, the presence of primary and acquired resistance to trastuzumab treatment remains a significant common challenge. …”
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    Mechanisms Behind the Resistance to Trastuzumab in HER2-Amplified Breast Cancer and Strategies to Overcome It
  5. 1445
    “…Trastuzumab is a first-line targeted drug used against HER2(+) breast cancers; however, at least 50% of HER2(+) tumors develop resistance to trastuzumab. …”
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    Bioorthogonal two-component drug delivery in HER2(+) breast cancer mouse models
  6. 1446
    por Huszno, Joanna, Nowara, Elżbieta
    Publicado 2016
    “…It is also an important predictor for response to trastuzumab, which has established efficacy against breast cancer with overexpression or amplification of the HER2 oncogene. Treatment with the anti-HER2 humanized monoclonal antibody – trastuzumab significantly improves progression-free and overall survival among patients with HER2-positive breast cancer. …”
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    Current therapeutic strategies of anti-HER2 treatment in advanced breast cancer patients
  7. 1447
    “…Trastuzumab, an antibody against HER2, has shown potent growth inhibitory effects on HER2 overexpressing tumors, including gastro-esophageal cancer, however, resistance to this therapy is inevitable. …”
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    ADAM10-mediated release of heregulin confers resistance to trastuzumab by activating HER3
  8. 1448
    por Ferrari, Anthony, Vincent-Salomon, Anne, Pivot, Xavier, Sertier, Anne-Sophie, Thomas, Emilie, Tonon, Laurie, Boyault, Sandrine, Mulugeta, Eskeatnaf, Treilleux, Isabelle, MacGrogan, Gaëtan, Arnould, Laurent, Kielbassa, Janice, Le Texier, Vincent, Blanché, Hélène, Deleuze, Jean-François, Jacquemier, Jocelyne, Mathieu, Marie-Christine, Penault-Llorca, Frédérique, Bibeau, Frédéric, Mariani, Odette, Mannina, Cécile, Pierga, Jean-Yves, Trédan, Olivier, Bachelot, Thomas, Bonnefoi, Hervé, Romieu, Gilles, Fumoleau, Pierre, Delaloge, Suzette, Rios, Maria, Ferrero, Jean-Marc, Tarpin, Carole, Bouteille, Catherine, Calvo, Fabien, Gut, Ivo Glynne, Gut, Marta, Martin, Sancha, Nik-Zainal, Serena, Stratton, Michael R., Pauporté, Iris, Saintigny, Pierre, Birnbaum, Daniel, Viari, Alain, Thomas, Gilles
    Publicado 2016
    “…HER2-positive breast cancer has long proven to be a clinically distinct class of breast cancers for which several targeted therapies are now available. …”
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    A whole-genome sequence and transcriptome perspective on HER2-positive breast cancers
  9. 1449
    “…MUCL1 expression is highest in HER2-amplified breast tumors and inhibiting HER2 activity in tumor cells resulted in a decreased MUCL1 expression. …”
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    HER2 drives Mucin-like 1 to control proliferation in breast cancer cells
  10. 1450
    “…Formalin-fixed paraffin-embedded tissue samples of esophageal biopsy specimens from 73 patients with Barrett’s esophagus with either low-grade dysplasia (LGD) (n = 32) or high-grade dysplasia (HGD) (n = 59) were analyzed for HER1, HER2, HER3 and CMET expression by immunohistochemistry (IHC). …”
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    HER3 Expression Is a Marker of Tumor Progression in Premalignant Lesions of the Gastroesophageal Junction
  11. 1451
    “…BACKGROUND: Human epidermal growth factor receptor-2 (HER2) is a transmembrane tyrosine kinase receptor that is overexpressed in 25 to 30 % of human breast cancers and is preferentially localized in lipid rafts. …”
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    Decreased expression of stomatin predicts poor prognosis in HER2-positive breast cancer
  12. 1452
    “…It is noteworthy that SRC1 expression was found to be related to HER-2 and Ki-67 expression (P=0.044 and P=0.001, respectively). …”
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    Clinical implications of the coexpression of SRC1 and NANOG in HER-2-overexpressing breast cancers
  13. 1453
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    Molecular Genealogy of a Mongol Queen’s Family and Her Possible Kinship with Genghis Khan
  14. 1454
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    Erratum to: Heregulin-1ß and HER3 in hepatocellular carcinoma: status and regulation by insulin
  15. 1455
    por Cusick, Sarah E., John, Chandy C.
    Publicado 2016
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    Iron, Inflammation, and Malaria in the Pregnant Woman and Her Child: Saving Lives, Saving Brains
  16. 1456
    “…BACKGROUND & OBJECTIVES: The proto-oncogene HER2/neu has been extensively studied in breast cancer patients. …”
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    Evaluation of HER2/neu oncoprotein in serum & tissue samples of women with breast cancer
  17. 1457
    “…Diagnostic assays for human epidermal growth factor receptor 2 (HER2) expression have a high predictive value because patients with HER2-positive tumors could benefit from HER2-targeted therapy. …”
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    FISH testing of HER2 immunohistochemistry 1+ invasive breast cancer with unfavorable characteristics
  18. 1458
    por Subrahmanyam, S.
    Publicado 1934
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    A Case of Deformity of the Bones of the Hand and Feet of a Mother Transmitted to Her Child
  19. 1459
    Publicado 1867
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    Report on Leprosy by the Royal College of Physicians, Prepared for Her Majesty's Secretary of State for the Colonies
  20. 1460
    por Sun, J, Chia, S
    Publicado 2017
    “…In this review, we discuss assessment tools to aid clinicians to select elderly patients who are ‘fit' for chemotherapy, and review the literature on the use of chemotherapy and of the anti-HER 2 antibody trastuzumab in this population. We will also review two commonly used prediction models to assess their accuracy in predicting survival outcomes in elderly patients. …”
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    Adjuvant chemotherapy and HER-2-directed therapy for early-stage breast cancer in the elderly
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