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1701por Antonarelli, G., Corti, C., Tarantino, P., Salimbeni, B.T., Zagami, P., Marra, A., Trapani, D., Tolaney, S., Cortes, J., Curigliano, G.“…In this review, we present the clinical landscape of HER2-positive advanced BC and discuss our vision on how to tackle T-DXd resistance, providing a perspective on the priority areas of the cancer research in this setting.…”
Publicado 2023
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1702por DeBusk, Kendra, Ike, Chiemeka, Lindegger, Nicolas, Schwartz, Naomi, Surinach, Andy, Liu, Yutong, Forero-Torres, Andres“…BACKGROUND: Among patients with human epidermal growth factor receptor 2-positive (HER2+) metastatic breast cancer (MBC), incidence of brain metastases (BMs) is relatively high and increasing. …”
Publicado 2022
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1703por Zhou, Li, Shao, Zhiting, Liu, Yiqiang, Yan, Xieqiao, Li, Juan, Wu, Xiaowen, Tang, Bixia, Li, Siming, Cui, Chuanliang, Chi, Zhihong, Si, Lu, Kong, Yan, Mao, Lili, Lian, Bin, Wang, Xuan, Bai, Xue, Dai, Jie, Guo, Jun, Sheng, Xinan“…BACKGROUND: The frequency of HER2 overexpression in bladder cancer is reported as 9%-61%. …”
Publicado 2023
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1704por Rainone, Michael, Behrendt, Carolyn E., Kasparian, Saro, Nguyen, Tina, Sedrak, Mina S., Lavasani, Sayeh, Stewart, Daphne B., Yuan, Yuan, Mortimer, Joanne E., Waisman, James R., Patel, Niki, Pullarkat, Vinod“…BACKGROUND: Thrombocytopenia is a common adverse event on HER2-targeted therapies, fam-trastuzumab deruxtecan (T-DXd) and ado-trastuzumab emtansine (T-DM1). …”
Publicado 2023
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1707por Dai, Lei-Jie, Ma, Ding, Xu, Yu-Zheng, Li, Ming, Li, Yu-Wei, Xiao, Yi, Jin, Xi, Wu, Song-Yang, Zhao, Ya-Xin, Wang, Han, Yang, Wen-Tao, Jiang, Yi-Zhou, Shao, Zhi-Ming“…Within HER2-low tumors, significant interpatient heterogeneity also exists in the hormone receptor–negative subgroup: basal-like tumors resemble HER2-0 disease, and non-basal-like HER2-low tumors mimic HER2-positive disease. …”
Publicado 2023
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1708“…RESULTS: The ICERs of T-DXd vs. chemotherapy were $83,892/QALY, $82,808/QALY, and $93,358/QALY in all HER2-low advanced BC patients, HER2-positive (HER2+) advanced BC patients and HER2-negative (HER2-) advanced BC patients, respectively. …”
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1709por Foroughi, Olivia, Madraswala, Shaheen, Hayes, Jennifer, Glover, Kara, Lee, Liam, Chaki, Moumita, Redpath, Stella, Yu, Agnes Weixuan, Chiu, David, Amanti, Kristen Garner, Gustavsen, Gary“…Despite the OlympiA trial demonstrating that early-stage, high-risk, HER2- germline BRCA1 and BRCA2 mutation (gBRCAm) positive breast cancer patients can benefit from PARPi in the adjuvant setting, the gBRCA testing rate in early-stage HR+/HER2− patients remains suboptimal compared to that in early-stage TNBC patients. …”
Publicado 2023
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1710por de Pinho, Inês Soares, Luz, Paulo, Alves, Lucy, Lopes-Brás, Raquel, Patel, Vanessa, Esperança-Martins, Miguel, Gonçalves, Lisa, Freitas, Ritas, Simão, Diana, Galnares, Maria Roldán, Fernandes, Isabel, Criado, Silvia Artacho, Casado, Salvador Gamez, Cañada, Jose Baena, Vega, Isabel M. Saffie, Costa, João G., Fernandes, Ana S., de Sousa, Rita Teixeira, Costa, Luís“…Patients receiving neoadjuvant therapy (NAT) with dual HER2 blockade (trastuzumab and pertuzumab), followed by surgery, were included. …”
Publicado 2023
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1711por Bai, Bijie, Wang, Hongda, Li, Yuzhu, de Haan, Kevin, Colonnese, Francesco, Wan, Yujie, Zuo, Jingyi, Doan, Ngan B., Zhang, Xiaoran, Zhang, Yijie, Li, Jingxi, Yang, Xilin, Dong, Wenjie, Darrow, Morgan Angus, Kamangar, Elham, Lee, Han Sung, Rivenson, Yair, Ozcan, Aydogan“…The efficacy of this virtual HER2 staining framework was demonstrated by quantitative analysis, in which three board-certified breast pathologists blindly graded the HER2 scores of virtually stained and immunohistochemically stained HER2 whole slide images (WSIs) to reveal that the HER2 scores determined by inspecting virtual IHC images are as accurate as their immunohistochemically stained counterparts. …”
Publicado 2022
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1712Correction: Induction of phenotypic changes in HER2-postive breast cancer cells in vivo and in vitropor Frank-Kamenetskii, Anastasia, Mook, Julia, Reeves, Meredith, Boulanger, Corinne A., Meyer, Thomas J., Ragle, Lauren, Jordan, H. Caroline, Smith, Gilbert H., Booth, Brian W.Enlace del recurso
Publicado 2023
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1713por Yang, Xue, Smirnov, Artem, Buonomo, Oreste Claudio, Mauriello, Alessandro, Shi, Yufang, Bischof, Julia, Woodsmith, Jonathan, Melino, Gerry, Candi, Eleonora, Bernassola, Francesca“…Here, we present the case of a 47-year-old woman diagnosed with luminal B breast cancer subtype and provide an in-depth analysis of her gene mutations, chromosomal alterations, mRNA and protein expression changes. …”
Publicado 2023
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1714“…Unfortunately, the use of subsequent HER2 targeted agents have not proven to be beneficial for HER2+ GC, although these agents are effective and currently being used for management of HER2+ breast cancer. …”
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1715por McDermott, Martina S. J., Browne, Brigid C., Conlon, Neil T., O’Brien, Neil A., Slamon, Dennis J., Henry, Michael, Meleady, Paula, Clynes, Martin, Dowling, Paul, Crown, John, O’Donovan, NormaEnlace del recurso
Publicado 2023
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1716“…Changes in the copy number aberration (CNA) landscape of luminal B HER2- negative (HER2−) breast cancer (BC) during anthracycline-based neoadjuvant chemotherapy (NAC) regimens were studied in order to identify groups of potential CNA markers of objective response and CNA markers for predicting the development of hematogenous metastasis. …”
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1717por Lin, Jiana, Zhang, Bingnan, Zou, Jintuo, Luo, Zhen, Yang, Hao, Zhou, Peng, Chen, Xiaoyang, Zhou, Wei“…BACKGROUND: Broussonetia papyrifera (L.) L’Hér. ex Vent. has the characteristics of strong stress resistance, high crude protein content, and pruning tolerance. …”
Publicado 2023
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1718por Park, Woong Ki, Nam, Seok Jin, Kim, Seok Won, Lee, Jeong Eon, Yu, Jonghan, Ryu, Jai Min, Chae, Byung Joo“…This retrospective study aimed to compare human epidermal growth factor receptor 2 (HER2)-low and HER2-0 breast cancers in hormone receptor (HR)-positive patients and investigate how it affect patients. …”
Publicado 2023
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1719por Nistor, Andreea, Watson, Peter H, Pettigrew, Norman, Tabiti, Karim, Dawson, Angelika, Myal, Yvonne“…BACKGROUND: The clinical benefit of determining the status of HER-2/neu amplification in breast cancer patients is well accepted. …”
Publicado 2006
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1720por Orlando, Laura, Cardillo, Anna, Ghisini, Raffaella, Rocca, Andrea, Balduzzi, Alessandra, Torrisi, Rosalba, Peruzzotti, Giulia, Goldhirsch, Aron, Pietri, Elisabetta, Colleoni, Marco“…BACKGROUND: HER2/neu overexpression is linked to promotion of angiogenesis in breast cancer. …”
Publicado 2006
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