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  1. 161
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    She adapts to her student: An expert pragmatic speaker tailoring her referring expressions to the Layman listener
  2. 162
    “…The context of a famous novel by Milan Kundera (Immortality) suggests that when faced with a life-or-death situation, every woman would prefer to save her child than her husband, left hanging whether every man would do the same. …”
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    Testing the Kundera Hypothesis: Does Every Woman (But Not Every Man) Prefer Her Child to Her Mate?
  3. 163
    “…INTRODUCTION: We have previously linked HER4 expression with increased survival in breast cancer. …”
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    HER4 in breast cancer: comparison of antibodies against intra- and extra-cellular domains of HER4
  4. 164
    “…BACKGROUND: Patients with HER2-overexpressing metastatic breast cancer, despite initially benefiting from the monoclonal antibody trastuzumab and the EGFR/HER2 tyrosine kinase inhibitor lapatinib, will eventually have progressive disease. …”
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    Phase I clinical trial of HER2-specific immunotherapy with concomitant HER2 kinase inhibtion
  5. 165
    “…Inside the nucleus, HER family members (EGFR, HER2, and HER3) have been shown to function as co-transcriptional activators for various cancer-promoting genes. …”
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    Mapping C-Terminal Transactivation Domains of the Nuclear HER Family Receptor Tyrosine Kinase HER3
  6. 166
    “…In tumours from postmenopausal women harbouring normal HER2 gene copy numbers, we found HER2 and HER4, but HER3 levels in particular, to be elevated (2.48, 1.30 and 22.27 –fold respectively; P<0.01 for each) compared to normal tissue. …”
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    Inverse Regulation of EGFR/HER1 and HER2-4 in Normal and Malignant Human Breast Tissue
  7. 167
    “…Four of the 7 tumors showed elevated GRB7 but not HER-2 mRNA over-expression. The breast cancer cell line HCC3153 did not over-express HER-2 protein but showed HER-2 FISH amplification of a limited segment around the HER-2 gene. …”
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    HER-2 gene amplification in human breast cancer without concurrent HER-2 over-expression
  8. 168
    “…INTRODUCTION: The availability of mice transgenic for the human HER2 gene (huHER2) and prone to the development of HER2-driven mammary carcinogenesis (referred to as FVB-huHER2 mice) prompted us to study active immunopreventive strategies targeting the human HER2 molecule in a tolerant host. …”
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    Vaccines against human HER2 prevent mammary carcinoma in mice transgenic for human HER2
  9. 169
    “…PURPOSE: The measurement of serum human epidermal growth factor receptor 2 (HER2) extracellular domain levels is a well-established method for evaluating whether a metastatic HER2-positive breast cancer patient will respond to HER2-targeted treatment. …”
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    Serial Serum HER2 Measurements for the Detection of Breast Cancer Recurrence in HER2-Positive Patients
  10. 170
    “…BACKGROUND: Data characterising long-term survivors (LTS) with human epidermal growth factor receptor 2 (HER2)–positive metastatic breast cancer (MBC) are limited. …”
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    Long-term survivor characteristics in HER2-positive metastatic breast cancer from registHER
  11. 171
    “…The salivary HER2 concentration was compared between the HER2-positive and HER2-negative groups using the Mann-Whitney U test. …”
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    Salivary expression of soluble HER2 in breast cancer patients with positive and negative HER2 status
  12. 172
    “…This HER-positive/uPAR-positive subtype may be partially responsible for the failure of HER2-targeted treatment strategies. …”
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    HER2 and uPAR cooperativity contribute to metastatic phenotype of HER2-positive breast cancer
  13. 173
    “…The receptor tyrosine kinase HER2 is known to play a central role in mitogenic signaling, motivating the development of targeted, HER2-specific therapies. …”
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    The level of HER2 expression is a predictor of antibody-HER2 trafficking behavior in cancer cells
  14. 174
    “…Hence, NRF2 regulates both HER2 and HER3 receptors to influence cellular responses to HER2 targeting monoclonal antibodies. …”
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    NRF2 Regulates HER2 and HER3 Signaling Pathway to Modulate Sensitivity to Targeted Immunotherapies
  15. 175
    “…HER2 is overexpressed in about 30% of feline mammary carcinomas (FMC) and in 15-30% of breast cancers. …”
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    Serum HER2 levels are increased in cats with mammary carcinomas and predict tissue HER2 status
  16. 176
    “…Importantly, EHF was identified as a new transcription factor for HER2 and HER3, contributing to thyroid tumorigenesis. …”
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    Increased expression of EHF contributes to thyroid tumorigenesis through transcriptionally regulating HER2 and HER3
  17. 177
    “…Currently, there are no recommended alternative assays for HER2 cases deemed equivocal by immunohistochemistry and fluorescent in situ hybridization. …”
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    Robust and accurate digital measurement for HER2 amplification in HER2 equivocal breast cancer diagnosis
  18. 178
    “…BACKGROUND: Targeted therapy with trastuzumab has become a mainstay for HER2-positive breast cancer without a clear understanding of the mechanism of its action. …”
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    The effects of trastuzumab on HER2-mediated cell signaling in CHO cells expressing human HER2
  19. 179
    “…Human epidermal growth factor receptor 1 or 2 (HER1/2), and fibroblast growth factor receptor 1 (FGFR1) signaling serve critical roles in the progression of breast cancer; however, cross-talk between HER1/2 and FGFR1 signaling has not been extensively studied. …”
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    FGFR1 and HER1 or HER2 co-amplification in breast cancer indicate poor prognosis
  20. 180
    “…BACKGROUND: HER2 gene amplification generates an enormous number of HER2 transcripts, but the global effects on endogenous miRNA targets including HER family members in breast cancer are unexplored. …”
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    Posttranscriptional upregulation of HER3 by HER2 mRNA induces trastuzumab resistance in breast cancer
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