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  1. 1781
    “…RESULTS: Since HER3 has been implicated in resistance to EGFR inhibitors, the efficacy of dually targeting both EGFR and HER3 in Ctx(R) models was evaluated. …”
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    Overcoming acquired resistance to cetuximab by dual targeting HER family receptors with antibody-based therapy
  2. 1782
    “…The current study investigates the involvement of HER2 in survival and radioresistance in PCa cells and we hypothesized that, by monitoring HER2 expression, treatment may be personalized. …”
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    Imaging of HER2 may improve the outcome of external irradiation therapy for prostate cancer patients
  3. 1783
    “…PURPOSE: Human epidermal growth factor receptor-2 (HER2) overexpression is a predictor of response to anti-HER2 therapy in breast and gastric cancer. …”
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    Development of the designed ankyrin repeat protein (DARPin) G3 for HER2 molecular imaging
  4. 1784
    “…Expression of the RTKs including EGFR, HER2, HER3, IGF-1R, and EphA2 was analyzed using immunohistochemistry (IHC). …”
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    Immunohistochemical analysis of RTKs expression identified HER3 as a prognostic indicator of gastric cancer
  5. 1785
    “…Phospho-p44/total p44 ERK levels were found to be increased by 2-fold in HER2(+) versus HER2(−) tumors. No difference was detected in phospho-p42/total p42 ERK levels. …”
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    Are Thyroid Hormone and Tumor Cell Proliferation in Human Breast Cancers Positive for HER2 Associated?
  6. 1786
    “…This study investigates whether high-density single nucleotide polymorphism (SNP) arrays can provide additional diagnostic power to assess HER2 gene status. METHODS: DNA from 65 breast tumor samples previously diagnosed by HER2 IHC and FISH analysis were blinded and examined for HER2 copy number variation employing SNP array analysis. …”
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    High-density SNP arrays improve detection of HER2 amplification and polyploidy in breast tumors
  7. 1787
    “…Ten pathologists scored 12 Her2/neu immunohistologically stained whole sections of gastric cancer. …”
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    Reproducibility of Her2/neu scoring in gastric cancer and assessment of the 10% cut-off rule
  8. 1788
    “…The small-sized (29 kDa) MaAbNA, which was expressed in E.coli, consists of one anti-EGFR1 nanobody and two anti-HER2 affibodies, and possesses high affinity (K(D)) for EGFR1 (~4.1 nM) and HER2 (~4.7 nM). …”
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    Small Sized EGFR1 and HER2 Specific Bifunctional Antibody for Targeted Cancer Therapy
  9. 1789
    “…PATIENTS AND METHODS: Patients with primary HER2-positive breast cancer treated with trastuzumab-based NST were categorised according to adjuvant trastuzumab administration and pCR status. …”
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    Effect of adjuvant trastuzumab among patients treated with anti-HER2-based neoadjuvant therapy
  10. 1790
    “…Furthermore, confocal microscopy revealed that HCN could specifically enter HER2-positive cancer cells. As a consequence, HCN could effectively kill HER2-positive cancer cells while not affecting HER2-negative cells.…”
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    Redox Potential Ultrasensitive Nanoparticle for the Targeted Delivery of Camptothecin to HER2-Positive Cancer Cells
  11. 1791
    “…Intrinsic and acquired resistance to the monoclonal antibody drug trastuzumab is a major problem in the treatment of HER2-positive breast cancer. A deeper understanding of the underlying mechanisms could help to develop new agents. …”
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    mRNA Profiling Reveals Determinants of Trastuzumab Efficiency in HER2-Positive Breast Cancer
  12. 1792
    “…Human epidermal growth factor receptor 2 (HER2) amplification/overexpression is an effective therapeutic target in breast and gastric cancer. …”
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    HER2 expression status in diverse cancers: review of results from 37,992 patients
  13. 1793
    “…BACKGROUND: Trastuzumab + chemotherapy is considered the standard therapy for advanced human epidermal growth factor receptor 2 (HER2)-positive gastric cancer with mild manageable toxicity, on the basis of the results of a pivotal phase-III trial. …”
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    A case of severe cerebral embolism after chemotherapy for HER2-positive gastric cancer
  14. 1794
    “…Amplification, overexpression, and somatic mutation of the HER2 gene have been reported to play a critical role in tumorigenesis of various cancers. …”
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    Phosphorylation of Mutationally Introduced Tyrosine in the Activation Loop of HER2 Confers Gain-of-Function Activity
  15. 1795
    “…BACKGROUND: Brain metastases are common in human epidermal growth factor receptor (Her)-2-positive breast cancer. Drug access to brain metastases and normal brain is key to management of cranial disease. …”
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    Lapatinib access into normal brain and brain metastases in patients with Her-2 overexpressing breast cancer
  16. 1796
    “…There is increasing evidence implicating HER3 in several types of cancer. But the development of targeted therapies to inactivate HER3 function has been a challenging endeavor. …”
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    Targeting HER3 by interfering with its Sec61-mediated cotranslational insertion into the endoplasmic reticulum
  17. 1797
    “…The test for homogeneity of trends (HER2– vs. HER2+ ) reached statistical significance only when evaluating physical activity during the first 10 years after menarche (P(homogeneity) = 0.03). …”
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    Reduced risk of breast cancer associated with recreational physical activity varies by HER2 status
  18. 1798
    “…We present the case of a 38-year-old woman admitted to our outpatient clinic with accelerating back pain and fatigue following a kick to her back by her husband. Upon arrival, we detected ST segment elevation in the D1, aVL, and V2 leads and accelerated idioventricular rhythm. …”
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    Traumatic Coronary Artery Dissection in a Young Woman after a Kick to Her Back
  19. 1799
    “…In the present study, we analyze the impact of 3D spatial organization of HER2-overexpressing breast cancer cells on the response to Trastuzumab. …”
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    Autophagy Protects from Trastuzumab-Induced Cytotoxicity in HER2 Overexpressing Breast Tumor Spheroids
  20. 1800
    “…Due to progressive CNS disease, intrathecal (IT) trastuzumab was introduced to enhance HER-2+ therapy into the CSF space. A combination HER-2+ targeted approach achieved clinical remission with stable disease in our patient 46 months after she was diagnosed with LM metastases. …”
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    Intrathecal trastuzumab: immunotherapy improves the prognosis of leptomeningeal metastases in HER-2+ breast cancer patient
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