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  1. 1841
    “…FST expression was also reduced in a mouse model of HER2/Neu-induced metastatic breast cancer. We found that FST blocks activin-induced breast epithelial cell migration in vitro, suggesting that its loss may promote breast cancer aggressiveness. …”
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    Follistatin is a metastasis suppressor in a mouse model of HER2-positive breast cancer
  2. 1842
    “…Trastuzumab combined with chemotherapy is standard of care for HER2 positive advanced gastro-esophageal cancers. …”
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    Discordance in HER2 Status in Gastro-esophageal Adenocarcinomas: A Systematic Review and Meta-analysis
  3. 1843
    “…To determine the efficacy of this approach, two clinically relevant cancer biomarkers, HER2 and TAG-72, were selected to represent models of internalizing and noninternalizing antigens, respectively. …”
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    In Vivo Pretargeted Imaging of HER2 and TAG-72 Expression Using the HaloTag Enzyme
  4. 1844
    “…We found that SMYD3 trimethylates HER2 protein at lysine 175. HER2 homodimerization was enhanced in the presence of SMYD3, and substitution of lysine 175 of HER2 with alanine (HER2‐K175A) reduced the formation of HER2 homodimers. …”
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    Protein lysine methyltransferase SMYD3 is involved in tumorigenesis through regulation of HER2 homodimerization
  5. 1845
    “…To determine whether PlncRNA-1 induces apoptosis in prostate cancer cells through the Her-2 pathway. The expression of PlncRNA-1, Her-2, and related cyclin proteins in 23 cases of prostate cancer and adjacent normal tissues was analyzed and compared. …”
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    PlncRNA-1 induces apoptosis through the Her-2 pathway in prostate cancer cells
  6. 1846
    “…Therapeutic efficacy resulting from combining Trastuzumab and Pertuzumab in the treatment of Her2 overexpressing breast cancer patients has been shown to increase patient survival. …”
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    A search for synergy in the binding kinetics of Trastuzumab and Pertuzumab whole and F(ab) to Her2
  7. 1847
    “…Proper tumor classification is likely to be critical for arriving at thorough conclusions regarding new HER2 and EGFR based treatment regimes.…”
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    HER2 and EGFR amplification and expression in urothelial carcinoma occurs in distinct biological and molecular contexts
  8. 1848
    “…The histology was poorly differentiated invasive ductal carcinoma (estrogen and progesterone receptor negative, HER2 positive) and the patient was negative for germline BRCA 1 and 2 mutations. …”
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    Exceptional Responses to Standard Therapy in a Patient with Metastatic HER2-Positive Breast Cancer
  9. 1849
    Publicado 1845
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    A Bill Enabling Her Majesty to Grant New Charters to Certain Colleges of Physicians and Surgeons
  10. 1850
    “…Here we describe how this approach is also applied to design molecular catalysts, as exemplified by Ni(ii) porphyrinoids catalyzing the hydrogen evolution reaction (HER). We found that β-hydrogenation of porphyrin remarkably enhances the electrocatalytic HER reactivity (turnover frequencies of 6287 vs. 265 s(–1) for Ni(ii) chlorin (Ni-2) and porphyrin (Ni-1), and of 1737 vs. 342 s(–1) for Ni(ii) hydroporpholactone (Ni-4) and porpholactone (Ni-3), respectively) using trifluoroacetic acid (TFA) as the proton source. …”
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    Enhancing the reactivity of nickel(ii) in hydrogen evolution reactions (HERs) by β-hydrogenation of porphyrinoid ligands
  11. 1851
    por Zhang, Wei, Tian, Huan, Yang, Shi-hong
    Publicado 2017
    “…To provide reference data, we retrospectively investigated the effects of neoadjuvant chemotherapy (NAC) on 119 patients with HER-2(+) locally advanced breast cancer, treated from November 2010 to July 2016, with respect to influencing factors and survival. …”
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    The Efficacy of Neoadjuvant Chemotherapy for HER-2-Positive Locally Advanced Breast Cancer and Survival Analysis
  12. 1852
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    Cardiotoxicity From Human Epidermal Growth Factor Receptor‐2 (HER2) Targeted Therapies
  13. 1853
    por De Mattos-Arruda, Leticia
    Publicado 2017
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    Liquid biopsy for HER2-positive breast cancer brain metastasis: the role of the cerebrospinal fluid
  14. 1854
    “…The majority of patients develop resistance against suppression of HER2-signaling mediated by trastuzumab in HER2 positive breast cancer (BC). …”
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    DUSP4 is associated with increased resistance against anti-HER2 therapy in breast cancer
  15. 1855
    por Watt, Lisa
    Publicado 2017
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    “Her Life Rests on Your Shoulders”: Doing Worry as Emotion Work in the Care of Children With Diabetes
  16. 1856
    por Macleod, D.
    Publicado 1857
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    Case of Complete Retroversion of the Uterus, Where the Mother Died, Undelivered, in the Tenth Month of Her Pregnancy
  17. 1857
    “…METHODS: The expression of MALAT1 in clinical samples with TNBC and Her-2 positive breast cancers was tested by qRT-PCR. …”
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    Roles of MALAT1 in development and migration of triple negative and Her-2 positive breast cancer
  18. 1858
    “…BACKGROUND: Detection of HER2/neu receptor overexpression and/or amplification is a prerequisite for efficient anti-HER2 treatment of breast and gastric carcinomas. …”
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    Physical basis of the ‘magnification rule’ for standardized Immunohistochemical scoring of HER2 in breast and gastric cancer
  19. 1859
    “…Monoclonal antibodies targeting Her2 are now used in the clinic to treat Her2 overexpression cancer patients. …”
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    A Single Domain–Based Anti-Her2 Antibody Has Potent Antitumor Activities
  20. 1860
    “…This pre-clinical study evaluates the impact of various parameters on the pharmacokinetics and efficacy of in vivo expressed DNA-based anti-HER2 monoclonal antibodies (mAbs), newly engineered and delivered via intramuscular electrotransfer in mice. …”
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    Prolonged in vivo expression and anti-tumor response of DNA-based anti-HER2 antibodies
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