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  1. 1861
    “…Over-expression of HER2 is generally considered to be a negative prognostic feature because it accompanies an increase in breast cancer mortality. …”
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    Practical consensus recommendations regarding the management of HER2 neu positive early breast cancer
  2. 1862
    “…Treatment options for MBC depend on several factors, including where the cancer has spread, the patient's overall health, and the levels of hormone receptors and HER2 in the tumour. Over-expression of HER2 is generally considered to be a negative prognostic feature because it accompanies an increase in breast cancer mortality. …”
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    Practical consensus recommendations regarding the management of HER2 neu positive metastatic breast cancer
  3. 1863
    “…Here we examined whether ER-c-Src-HER2 complex formation is involved in tamoxifen resistance. …”
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    C-Cbl reverses HER2-mediated tamoxifen resistance in human breast cancer cells
  4. 1864
    “…Brain metastases constitute a challenge in the management of patients with HER2-positive breast cancer treated with anti-HER2 systemic therapies. …”
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    Genetic heterogeneity and actionable mutations in HER2-positive primary breast cancers and their brain metastases
  5. 1865
    “…Human epidermal growth factor receptor 2 (HER2) is an oncogenic driver, and a well-established therapeutic target in breast and gastric cancers. …”
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    Targeting the human epidermal growth factor receptor 2 (HER2) oncogene in colorectal cancer
  6. 1866
    “…The discovered crosstalk between EGFR and HER3 as well as the role of HER3 in mediating EGFR resistance made these two receptor tyrosine kinases attractive targets. …”
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    Imaging EGFR and HER3 through (89)Zr-labeled MEHD7945A (Duligotuzumab)
  7. 1867
    “…Recent work has shown that HER2/neu-positive breast cancer cells rely on a unique Warburg-like metabolism for survival and aggressive behavior. …”
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    Global metabolite profiling analysis of lipotoxicity in HER2/neu-positive breast cancer cells
  8. 1868
    “…Conclusions: Our findings suggest that iNOS inhibition is a promising cardioprotective strategy to accompany HER2-inhibitor/anthracycline combination therapies. …”
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    The HER2 inhibitor lapatinib potentiates doxorubicin-induced cardiotoxicity through iNOS signaling
  9. 1869
    “…The study aimed to investigate factors that are associated with a mother being worried about her child’s choosy feeding behaviour. Parents of singleton children from the Avon Longitudinal Study of Parents and Children (n = 5710) completed a questionnaire assessing perception of their child’s choosy feeding behaviour at 15 months of age and whether this choosiness worried them. …”
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    Factors Associated with Maternal Worry about Her Young Child Exhibiting Choosy Feeding Behaviour
  10. 1870
    “…BACKGROUND: HER2 over-expression is related with a poor prognosis in patients with invasive breast cancer tumors. …”
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    Mutant p53 gain of function induces HER2 over-expression in cancer cells
  11. 1871
    “…RESULTS: HER2 positivity was seen in 16/70 cases (23%). 6 cases (8.5%) were equivocal and 48/70 cases (68.5%) were HER2 negative. …”
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    Immuno-Histochemical Assessment of HER2NEU Expression in Gastric Adenocarcinoma in North Karnataka, India
  12. 1872
    “…The expression of CD44st mRNA is correlated with HER-2 expression in postoperative breast cancer patients.…”
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    A correlation study of the expression of HA-CD44st and HER-2 in breast cancer
  13. 1873
    “…BACKGROUND: Human epidermal growth factor receptor 2 (HER2)-positive gastric cancer (GC) is a unique subtype of this disease. …”
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    Efficacy and safety of trastuzumab as maintenance or palliative therapy in advanced HER2-positive gastric cancer
  14. 1874
    “…All breast cancers are assessed for levels of human epidermal growth factor receptor 2 (HER2). Fluorescence in situ hybridization (FISH) and immunohistochemistry are currently used to determine if a patient is eligible for anti-HER2 therapy. …”
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    Single molecule localization microscopy coupled with touch preparation for the quantification of trastuzumab-bound HER2
  15. 1875
    por Nami, Babak, Maadi, Hamid, Wang, Zhixiang
    Publicado 2018
    “…Human epidermal growth factor receptor (HER) 2 (HER2) is overexpressed in 20–30% of breast cancers. …”
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    Mechanisms Underlying the Action and Synergism of Trastuzumab and Pertuzumab in Targeting HER2-Positive Breast Cancer
  16. 1876
    “…HER-3 should heterodimerize with other members of ErbB receptor family, especially with HER-2, to transduce downstream signaling pathways. …”
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    HER-3 Knocking Down Induces G2/M Arrest in Gastric Cancer Cells
  17. 1877
    “…Although HER2 is a cell membrane receptor, differential rates of endocytosis and recycling engender a dynamic surface pool of HER2. …”
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    Caveolin-1 mediates cellular distribution of HER2 and affects trastuzumab binding and therapeutic efficacy
  18. 1878
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    PERSEPHONE: are we ready to de-escalate adjuvant trastuzumab for HER2-positive breast cancer?
  19. 1879
    “…BACKGROUND: The overexpression of HER2 is associated with worse prognosis of breast cancer which responds favourably to anti-HER2 therapy. …”
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    HER2 overexpression and correlation with other significant clinicopathologic parameters in Ivorian breast cancer women
  20. 1880
    “…The correlation between CD44st and HER2 expression and clinical pathological features was examined. …”
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    Effect of CD44st and HER2 expression on the postoperative prognosis of breast cancer patients
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