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  1. 1
    por Hyman, David M., Piha-Paul, Sarina A., Won, Helen, Rodon, Jordi, Saura, Cristina, Shapiro, Geoffrey I., Juric, Dejan, Quinn, David I., Moreno, Victor, Doger, Bernard, Mayer, Ingrid A., Boni, Valentina, Calvo, Emiliano, Loi, Sherene, Lockhart, Albert C., Erinjeri, Joseph P., Scaltriti, Maurizio, Ulaner, Gary A., Patel, Juber, Tang, Jiabin, Beer, Hannah, Selcuklu, S. Duygu, Hanrahan, Aphrothiti J., Bouvier, Nancy, Melcer, Myra, Murali, Rajmohan, Schram, Alison M., Smyth, Lillian M., Jhaveri, Komal, Li, Bob T., Drilon, Alexander, Harding, James J., Iyer, Gopa, Taylor, Barry S., Berger, Michael F., Cutler, Richard E., Xu, Feng, Butturini, Anna, Eli, Lisa D., Mann, Grace, Farrell, Cynthia, Lalani, Alshad S., Bryce, Richard P., Arteaga, Carlos L., Meric-Bernstam, Funda, Baselga, José, Solit, David B.
    Publicado 2018
    “…Somatic mutations of ERBB2 (HER2) and ERBB3 (HER3) are found in a wide range of cancers. …”
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    HER kinase inhibition in patients with HER2- and HER3-mutant cancers
  2. 2
    “…INTRODUCTION: The HER (human EGFR related) family of receptor tyrosine kinases (HER1/EGFR (epidermal growth factor receptor)/c-erbB1, HER2/c-erbB2, HER3/c-erbB3 and HER4/c-erbB4) shares a high degree of structural and functional homology. …”
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    Cytogenetic analysis of HER1/EGFR, HER2, HER3 and HER4 in 278 breast cancer patients
  3. 3
    “…HER2 and HER3 play key driving functions in the pathophysiology of HER2-amplified breast cancers, but this function is less well characterized in other cancers driven by HER2 amplification. …”
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    The role of HER2 and HER3 in HER2-amplified cancers beyond breast cancers
  4. 4
    “…The HER/ErbB family of receptor tyrosine kinases drives critical responses in normal physiology and cancer, and the expression levels of the various HER receptors are critical determinants of clinical outcomes. …”
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    Model-Based Analysis of HER Activation in Cells Co-Expressing EGFR, HER2 and HER3
  5. 5
    “…Increased expression of the epidermal growth factor (EGF) receptors, HER1 and HER2 are related to poor prognosis in most cancers studied. …”
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    The relation between survival and expression of HER1 and HER2 depends on the expression of HER3 and HER4: a study in bladder cancer patients
  6. 6
    por Metheny, Pat
    Publicado 1987
    “…In her family;…”
    Partituras Libro
    In her family /
  7. 7
    por Andrijević Matovac, Vesna
    Publicado 2011
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    “Everything for Her!”
  8. 8
    Publicado 1947
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    ADVICE TO THE EXPECTANT MOTHER ON THE CARE OF HER HEALTH AND THAT OF HER CHILD
  9. 9
    “…AIM OF THE STUDY: To determine whether the expression of HER-3 influences the survival of HER-2 positive patients with breast cancer (BC). …”
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    HER-3 expression in HER-2-amplified breast carcinoma
  10. 10
    Publicado 1943
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    Online Artículo Texto
    Advice to the Expectant Mother on the Care of Her Health and That of Her Child
  11. 11
    Publicado 1941
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    Online Artículo Texto
    Advice to the Expectant Mother on the Care of Her Health and That of Her Child
  12. 12
    Publicado 1947
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    Advice to the Expectant Mother on the Care of Her Health and That of Her Child
  13. 13
    “…Trastuzumab is effective in the treatment of HER2/neu over-expressing breast cancer, but not all patients benefit from it. …”
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    HER3, p95HER2, and HER2 protein expression levels define multiple subtypes of HER2-positive metastatic breast cancer
  14. 14
    “…BACKGROUND: Lapatinib plus capecitabine is an effective treatment option for trastuzumab-refractory HER2-positive metastatic breast cancer. We have investigated the correlation between quantitative measures of HER2, p95HER2, and HER3 and treatment outcomes using lapatinib and capecitabine. …”
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    Correlation of HER2, p95HER2 and HER3 Expression and Treatment Outcome of Lapatinib plus Capecitabine in her2-Positive Metastatic Breast Cancer
  15. 15
    “…Differences in biology between these two tumor types, however, are poorly understood. Considering anti-HER2 drugs bind directly to HER2 protein on the cell surface, we hypothesized anti-HER2 therapies would be less effective in IHC(2+)/FISH(+) tumors than in IHC(3+) tumors, leading to differences in patient outcomes. …”
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    Comparison of tumors with HER2 overexpression versus HER2 amplification in HER2-positive breast cancer patients
  16. 16
    “…Effective prevention of human cancer with vaccines against viruses, such as HBV and HPV, raises the question whether also non-virus related tumors could be prevented with immunological means. Studies in HER-2-transgenic mice showed that powerful anti-HER-2 vaccines, could almost completely prevent the onset of mammary carcinoma. …”
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    Preclinical HER-2 Vaccines: From Rodent to Human HER-2
  17. 17
    “…EGFR, HER2, and HER3 contribute to the initiation and progression of human cancers, and are therapeutic targets for monoclonal antibodies and tyrosine kinase inhibitors. …”
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    Novel agents that downregulate EGFR, HER2, and HER3 in parallel
  18. 18
    “…HER2 has no recognized ligands and heterodimers between HER2 and EGFR (ErbB1/HER1) or HER2 and ErbB3/HER3 are important in breast cancer. …”
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    HER2 signaling regulates HER2 localization and membrane retention
  19. 19
    “…OBJECTIVES: Human epidermal growth factor receptor-2 (HER2) and 3 (HER3) belong to the epidermal growth factor receptor (EGFR) family of transmembrane receptor tyrosine kinases. …”
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    Overexpression of HER2/HER3 and clinical feature of ovarian cancer
  20. 20
    “…Hanker et al. reveal that co-occurring missense mutations in the human epidermal growth factor receptor 2 (HER2) and its catalytically inactive homolog HER3 synergize to promote oncogenic signaling by the HER2/HER3 complex.…”
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    Mutant HER2 needs mutant HER3 to be an effective oncogene
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