Materias dentro de su búsqueda.
Mostrando 21 - 40 Resultados de 775 Para Buscar '"Hergé"', tiempo de consulta: 0.30s Limitar resultados
  1. 21
    por Babcock, Joseph J, Li, Min
    Publicado 2013
    “…However, growing evidence implicates hERG in a diversity of physiologic and pathological processes. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    hERG channel function: beyond long QT
  2. 22
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Towards a complete structure of the hERG channel
  3. 23
    “…This study examines the interaction between hERG and Kv4.3. The functional interaction between hERG and Kv4.3, expressed in a heterologous cell line, was studied using patch clamp techniques, western blot, immunofluorescence, and co-immunoprecipitation. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Kv4.3 Modulates the Distribution of hERG
  4. 24
    “…In this work, we combine molecular dynamics simulations, mutagenesis, and electrophysiology to provide mechanistic insights into how lipophilic molecules (ceramide-sphingolipid probe) alter gating kinetics and K(+) currents of hERG1. We show that the sphingolipid probe induced a significant left shift of activation voltage, faster deactivation rates, and current blockade comparable to traditional hERG1 blockers. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Lipid regulation of hERG1 channel function
  5. 25
    “…In this study, we investigated the role of ER chaperone proteins (Calnexin and Calreticulin) in the processing of G572R-hERG and E637K-hERG mutant proteins. METHODS: pcDNA3-WT-hERG, pcDNA3-G572R-hERG and pcDNA3-E637K-hERG plasmids were transfected into U2OS and HEK293 cells. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Trafficking-Deficient G572R-hERG and E637K-hERG Activate Stress and Clearance Pathways in Endoplasmic Reticulum
  6. 26
    “…Assessing the hERG liability in the early stages of drug discovery programs is important. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Support Vector Machine model for hERG inhibitory activities based on the integrated hERG database using descriptor selection by NSGA-II
  7. 27
    “…It causes a significant reduction of the fully-glycosylated (fg) hERG1a protein expression but upregulates both core-glycosylated (cg) expression and hERG1a-Hsp90 complexes, suggesting possible impaired hERG1a trafficking. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Mitragynine, an euphoric compound inhibits hERG1a/1b channel current and upregulates the complexation of hERG1a-Hsp90 in HEK293-hERG1a/1b cells
  8. 28
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Differential expression of hERG1A and hERG1B genes in pediatric acute lymphoblastic leukemia identifies different prognostic subgroups
  9. 29
    por Um, Sung Yon, McDonald, Thomas V.
    Publicado 2007
    “…The small proteins encoded by KCNE1 and KCNE2 have both been proposed as accessory subunits for the HERG channel. Here we report our investigation into the cell biology of the KCNE-HERG interaction. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Texto
    Differential Association between HERG and KCNE1 or KCNE2
  10. 30
    por Smith, Paula L., Yellen, Gary
    Publicado 2002
    “…HERG encodes an inwardly-rectifying potassium channel that plays an important role in repolarization of the cardiac action potential. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Texto
    Fast and Slow Voltage Sensor Movements in HERG Potassium Channels
  11. 31
    “…In this study, we identify saxitoxin (STX) as a hERG channel modifier and investigate the mechanism using heterologous expression of the recombinant channel in HEK293 cells. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Texto
    Saxitoxin Is a Gating Modifier of hERG K(+) Channels
  12. 32
    “…We studied wild-type (WT) and mutant HERG currents and used two strategic probes, intracellular Na(+) (Na(+) (i)) and extracellular Ba(2+) (Ba(2+) (o)), to define a site where Na(+) (o) interacts with HERG. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Texto
    Extracellular Sodium Interacts with the HERG Channel at an Outer Pore Site
  13. 33
    por Zhang, Mei, Liu, Jie, Tseng, Gea-Ny
    Publicado 2004
    “…The hERG channel has a relatively slow activation process but an extremely fast and voltage-sensitive inactivation process. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Texto
    Gating Charges in the Activation and Inactivation Processes of the hERG Channel
  14. 34
    “…Here, we characterize the effects of Cd(2+) on hERG1 gating currents in Xenopus oocytes using the cut-open Vaseline gap technique. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Texto
    Modification of hERG1 channel gating by Cd(2+)
  15. 35
    “…Eag and HERG are expressed in cancers of various organs and have been implicated in cell cycle progression and proliferation of cancer cells. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Texto
    Eag and HERG potassium channels as novel therapeutic targets in cancer
  16. 36
    “…Our aim was to examine the effects of celecoxib on hERG and other human channels critically involved in regulating human cardiac rhythm, and to explore the mechanisms of any observed effect on the hERG channels. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Inhibition of hERG Potassium Channels by Celecoxib and Its Mechanism
  17. 37
    “…In a previous report we demonstrated that ginsenoside Rg(3) regulates HERG K(+) channels by decelerating deactivation. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Differential Effects of Ginsenoside Metabolites on HERG K(+) Channel Currents
  18. 38
    “…BACKGROUND: Drugs that bind to the human Ether-a-go-go Related Gene (hERG) potassium channel and block its ion conduction can lead to Torsade de Pointes (TdP), a fatal ventricular arrhythmia. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    A fingerprint pair analysis of hERG inhibition data
  19. 39
    “…The hERG potassium channel is critical for repolarisation of the cardiac action potential. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Endocytosis of hERG Is Clathrin-Independent and Involves Arf6
  20. 40
    “…HERG channel activity is up-regulated by growth factors. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Up-Regulation of hERG K(+) Channels by B-RAF
Herramientas de búsqueda: RSS