Materias dentro de su búsqueda.
Mostrando 41 - 60 Resultados de 775 Para Buscar '"Hergé"', tiempo de consulta: 0.18s Limitar resultados
  1. 41
    “…Probucol is a cholesterol-lowering drug that could reduce hERG current by decreasing plasma membrane hERG protein expression and eventually cause long QT syndrome. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Mechanisms underlying probucol-induced hERG-channel deficiency
  2. 42
    “…The purpose of this study was to investigate the effect of moxifloxacin on HERG channel protein and glucose metabolism. HERG expression was investigated using immunohistochemistry. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    HERG Protein Plays a Role in Moxifloxacin-Induced Hypoglycemia
  3. 43
    “…Human ether-à-go-go related gene (hERG) 1 channels conduct the rapid delayed rectifier K(+) current (I(Kr)) and are essential for the repolarization of the cardiac action potential. hERG1 inhibition by structurally diverse drugs may lead to life threatening arrhythmia. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    New potential binding determinant for hERG channel inhibitors
  4. 44
    “…It is involved in the repolarization and termination of action potentials in excitable cardiac cells. Mutations in the hERG gene and hERG channel blockage by small molecules are associated with increased risk of fatal arrhythmias. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Natural products modulating the hERG channel: heartaches and hope
  5. 45
    “…The recent increase in SAR information about hERG inhibitors in public databases has led to many successful applications of machine learning techniques to predict hERG inhibition. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Construction of an integrated database for hERG blocking small molecules
  6. 46
    “…Therefore, a virtual screening method to predict drug-induced hERG-related cardiotoxicity could facilitate drug discovery by filtering out toxic drug candidates. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Computational determination of hERG-related cardiotoxicity of drug candidates
  7. 47
    “…In contrast, S624A hERG was inhibited more potently than WT hERG, with a ~ 34% stronger inhibition. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    The molecular determinants of R-roscovitine block of hERG channels
  8. 48
    “…Because of its impact on human health, understanding the molecular mechanism of C-type inactivation in hERG represents an advance of paramount importance. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Mechanism of C-type inactivation in the hERG potassium channel
  9. 49
    por Yu, Ran, Li, Peng
    Publicado 2021
    “…QT prolongation is usually related to the human ether-a-go-go-related gene (hERG) potassium channel inhibitory activity of most drugs. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Computational and experimental studies on the inhibitory mechanism of hydroxychloroquine on hERG
  10. 50
    “…Tan) [1], which the possible hERG blocking properties of deoxyelephantopin were investigated. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Data on the construction of a recombinant HEK293 cell line overexpressing hERG potassium channel and examining the presence of hERG mRNA and protein expression
  11. 51
    “…The human ether-a-go-go-related gene (hERG) not only encodes a potassium-selective voltage-gated ion channel essential for normal electrical activity in the heart but is also a major drug anti-target. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Structural modeling of hERG channel–drug interactions using Rosetta
  12. 52
    “…We used a mutant HERG (D540K) channel expressed in Xenopus oocytes to test the trapping hypothesis. …”
    Enlace del recurso
    Enlace del recurso
    Texto
    Trapping of a Methanesulfonanilide by Closure of the Herg Potassium Channel Activation Gate
  13. 53
    “…Human ether-à-go-go–related gene (hERG) channels mediate cardiac repolarization and bind drugs that can cause acquired long QT syndrome and life-threatening arrhythmias. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Texto
    hERG Gating Microdomains Defined by S6 Mutagenesis and Molecular Modeling
  14. 54
    “…The human ether-a-go-go-related gene potassium channel (hERG, Kv11.1, KCNH2) has an essential role in cardiac action potential repolarization. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Novel roles for hERG K(+) channels in cell proliferation and apoptosis
  15. 55
    “…A positive hERG assay has been embraced by regulators as a non-clinical predictor of TdP despite a discordance of about 30%. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    MICE Models: Superior to the HERG Model in Predicting Torsade de Pointes
  16. 56
    “…The human ether-à-go-go-related gene (hERG)1 K(+) channel is upregulated in human colorectal cancer cells and primary samples. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Characterization of hERG1 channel role in mouse colorectal carcinogenesis
  17. 57
    “…Dysfunction of hERG channel can cause long QT syndrome. However, the regulatory mechanisms of BBR effects on hERG at cell membrane level remain unknown. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Mechanism and pharmacological rescue of berberine-induced hERG channel deficiency
  18. 58
    “…Mutations that reduce inactivation of the voltage-gated Kv11.1 potassium channel (hERG) reduce binding for a number of blockers. State specific block of the inactivated state of hERG block may increase risks of drug-induced Torsade de pointes. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Role of the pH in state-dependent blockade of hERG currents
  19. 59
    “…HERG expression may be the cause of deterioration in cardiomyopathy. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    The association between HERG gene expression and cardiac arrhythmia disease in children
  20. 60
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    The Basis for Low-affinity hERG Potassium Channel Block by Sotalol
Herramientas de búsqueda: RSS