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202“…CONCLUSIONS: By examining the HERV-K(HML-2) proviral content of 145 humans we detected a new insertionally polymorphic Type I HERV-K(HML-2) provirus. …”
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203por Rastogi, Anshu, Ali, Amina, Tan, Shyh-Han, Banerjee, Sreedatta, Chen, Yongmei, Cullen, Jennifer, Xavier, Charles P., Mohamed, Ahmed A., Ravindranath, Lakshmi, Srivastav, Jigisha, Young, Denise, Sesterhenn, Isabell A., Kagan, Jacob, Srivastava, Sudhir, McLeod, David G., Rosner, Inger L., Petrovics, Gyorgy, Dobi, Albert, Srivastava, Shiv, Srinivasan, Alagarsamy“…In addition, the data also suggest that AAbs against ERG together with AMACR and HERV-K Gag may be a useful panel of biomarkers for diagnosis and prognosis of CaP.…”
Publicado 2016
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204por Ko, Eun-Ji, Ock, Mee-Sun, Choi, Yung-Hyun, Iovanna, Juan L., Mun, Seyoung, Han, Kyudong, Kim, Heui-Soo, Cha, Hee-Jae“…To elucidate the function of HERV-K Env protein in cancers, an HERV-K env gene knockout (KO) in DLD-1 colorectal cancer cell lines was generated using the CRISPR-Cas9 system. …”
Publicado 2021
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205“…The identified HERV loci belonged to 36 different HERV groups, including members of all three classes. …”
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208por Esnault, Cécile, Priet, Stéphane, Ribet, David, Heidmann, Odile, Heidmann, Thierry“…RESULTS: Here we show that the IAPE element, which is the infectious progenitor of the strictly intracellular IAP elements, and the infectious human endogenous retrovirus HERV-K are restricted by both murine and human APOBEC3 proteins in an ex vivo assay for infectivity, with evidence in most cases of strand-specific G-to-A editing of the proviruses, with the expected signatures. …”
Publicado 2008
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209por Chen, Xiaoli, Wang, Jun, Mitchell, Elyse, Guo, Jin, Wang, Liwen, Zhang, Yu, Hodge, Jennelle C, Shen, Yiping“…BACKGROUND: Human endogenous retroviral (HERV) sequences are the remnants of ancient retroviral infection and comprise approximately 8% of the human genome. …”
Publicado 2014
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210“…The human endogenous retrovirus (HERV)-K, human mouse mammary tumor virus like-2 (HML-2) subgroup of HERVs is activated in several tumors and has been related to prostate cancer progression and motor neuron diseases. …”
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211por Garson, Jeremy A., Usher, Louise, Al-Chalabi, Ammar, Huggett, Jim, Day, Edmund F., McCormick, Adele L.“…Known human exogenous retroviruses such as HIV-1 have been eliminated as possible sources of this activity and investigators have therefore considered the possibility that human endogenous retroviruses (HERVs) might be involved. HERV-K (HML-2) is the most recent retroviral candidate to be proposed following the observation of elevated HERV-K expression in cortical and spinal neurons of ALS patients and the demonstration of HERV-K envelope protein neurotoxicity in vitro and in transgenic mice. …”
Publicado 2019
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212por Yan, Qiujin, Wu, Xiulin, Zhou, Ping, Zhou, Yan, Li, Xuhang, Liu, Zhongchun, Tan, Huawei, Yao, Wei, Xia, Yaru, Zhu, Fan“…An increasing number of studies have begun considering human endogenous retroviruses (HERVs) as potential pathogenic phenomena. Our previous research suggests that HERV-W Envelope (HERV-W ENV), a HERV-W family envelope protein, is elevated in schizophrenia patients and contributes to the pathophysiology of schizophrenia. …”
Publicado 2022
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214por Grandi, Nicole, Cadeddu, Marta, Pisano, Maria Paola, Esposito, Francesca, Blomberg, Jonas, Tramontano, Enzo“…HERV-K elements (classified as HML1–10) are among the most studied HERV groups, especially due to their possible correlation with human diseases. …”
Publicado 2017
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215por Kaplan, Mark H., Contreras-Galindo, Rafael, Jiagge, Evelyn, Merajver, Sofia D., Newman, Lisa, Bigman, Galya, Dosik, Michael H., Palapattu, Ganesh S., Siddiqui, Javed, Chinnaiyan, Arul M., Adebamowo, Sally, Adebamowo, Clement“…The human endogenous retroviruses HERV-K HML-2 have been considered a possible cause of human breast cancer (BrC). …”
Publicado 2020
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216“…Being with the biological source of COVID-19 undetected, the role of human endogenous retrovirus (HERVs) in the regulation of the host cell gene expression or the encoding for products that could modulate COVID-19 infection and the spectrum of its symptoms is discussed.…”
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219por Wu, Xiulin, Yan, Qiujin, Liu, Lianzhong, Xue, Xing, Yao, Wei, Li, Xuhang, Li, Wenshi, Ding, Shuang, Xia, Yaru, Zhang, Dongyan, Zhu, Fan“…Our previous studies show that HERV-W env is elevated in schizophrenia and HERV-W env can increase calcium influx. …”
Publicado 2022
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220por Tamouza, Ryad, Meyer, Urs, Lucas, Alexandre, Richard, Jean Romain, Nkam, Irène, Pinot, Armand, Djonouma, Ndilyam, Boukouaci, Wahid, Charvet, Benjamin, Pierquin, Justine, Brunel, Joanna, Fourati, Slim, Rodriguez, Christophe, Barau, Caroline, Le Corvoisier, Philippe, El Abdellati, Kawtar, De Picker, Livia, Perron, Hervé, Leboyer, Marion“…Such infections can activate retro-transposable genetic elements (HERV) known to trigger immune receptors and impair synaptic plasticity of neuroreceptors. …”
Publicado 2023
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