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  1. 6501
    “…Human endogenous retroviruses (HERVs) are derived from exogenous retrovirus infections in the evolution of primates and account for about 8% of the human genome. …”
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    Human Endogenous Retrovirus K (HML-2) in Health and Disease
  2. 6502
    por Russ, Eric, Iordanskiy, Sergey
    Publicado 2023
    “…The biological activity of HERVs in the context of the innate immune response can be based on the functional effect of four major viral components: (1) HERV LTRs, (2) HERV-derived RNAs, (3) HERV-derived RNA:DNA duplexes and cDNA, and (4) HERV-derived proteins and ribonucleoprotein complexes. …”
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    Endogenous Retroviruses as Modulators of Innate Immunity
  3. 6503
    por Grandi, Nicole, Tramontano, Enzo
    Publicado 2018
    “…About 8% of our genome is composed of sequences with viral origin, namely human Endogenous Retroviruses (HERVs). HERVs are relics of ancient infections that affected the primates' germ line along the last 100 million of years, and became stable elements at the interface between self and foreign DNA. …”
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    Human Endogenous Retroviruses Are Ancient Acquired Elements Still Shaping Innate Immune Responses
  4. 6504
    “…Human endogenous retroviruses (HERVs) constitute 5–8% of human genomic DNA and are replication incompetent despite expression of individual HERV genes from different chromosomal loci depending on the specific tissue. …”
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    Human endogenous retroviruses and multiple sclerosis: Innocent bystanders or disease determinants?
  5. 6505
    “…We identified significant differences between differentially expressed HERVs and non-differentially expressed HERVs between the two datasets. …”
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    Expression of Human Endogenous Retroviruses in Systemic Lupus Erythematosus: Multiomic Integration With Gene Expression
  6. 6506
    “…Expression of the HERV-K envelope gene (env) was highly significantly increased in basal tumors in comparison with the also-upregulated expression of other HERV-K genes. …”
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    Expression of human endogenous retrovirus-K is strongly associated with the basal-like breast cancer phenotype
  7. 6507
    “…Unlike AcHERV-MERS vaccines, AcHERV-COVID19-S provided the greatest protection against SARS-CoV2 challenge. …”
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    Human endogenous retrovirus-enveloped baculoviral DNA vaccines against MERS-CoV and SARS-CoV2
  8. 6508
    “…Because of the high sequence similarity between different HERV-Ks, current methods have limitations in providing genome-wide mapping specific for individual HERV-K (HML-2) members, a major barrier in delineating HERV-K (HML-2) function. …”
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    Identification of the distribution of human endogenous retroviruses K (HML-2) by PCR-based target enrichment sequencing
  9. 6509
    “…The role of HERVs in multiple malignancies has been demonstrated, however, the extent to which HERV activation and expression participate in the development of cancer is not yet fully comprehended. …”
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    Human endogenous retroviruses in cancer: Oncogenesis mechanisms and clinical implications
  10. 6510
    “…The dynamic regulation of HERV activity and their responsiveness to a variety of environmental stimuli designate HERVs as genetic elements that could be modulated by drugs. …”
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    The Decrease in Human Endogenous Retrovirus-H Activity Runs in Parallel with Improvement in ADHD Symptoms in Patients Undergoing Methylphenidate Therapy
  11. 6511
    “…The human genome contains many retroviral elements called human endogenous retroviruses (HERVs), resulting from the integration of retroviruses throughout evolution. …”
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    Human Endogenous Retroviruses as Gene Expression Regulators: Insights from Animal Models into Human Diseases
  12. 6512
    por Lee, Young Nam, Bieniasz, Paul D
    Publicado 2007
    “…Nonetheless, one family of HERVs, namely HERV-K(HML-2), may have replicated in human ancestors less than 1 million years ago. …”
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    Reconstitution of an Infectious Human Endogenous Retrovirus
  13. 6513
    “…The present data support the involvement of HERVs in ASD and suggest HERVs and cytokines as ASD-associated traits. …”
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    Children With Autism Spectrum Disorder and Their Mothers Share Abnormal Expression of Selected Endogenous Retroviruses Families and Cytokines
  14. 6514
    “…In this study, we used a recently described high-density microarray which can be used to study HERV/MaLR transcriptome including 353,994 HERV/MaLR loci and 1559 immunity-related genes. …”
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    LTR-retrotransposon transcriptome modulation in response to endotoxin-induced stress in PBMCs
  15. 6515
    “…Given that human endogenous retroviruses (HERVs) are known to be activated during and participate in inflammatory processes, we examined whether HERV dysregulation signatures are present in COVID-19 patients. …”
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    Upregulation of Human Endogenous Retroviruses in Bronchoalveolar Lavage Fluid of COVID-19 Patients
  16. 6516
    por Bhetariya, PJ, Kriesel, JD, Fischer, KF
    Publicado 2017
    “…Expression of HERV ENV clades 2, 3A, 3B, mapping to RTVL, HERV-E and HERV-K and MSRV (HERV-W), were significantly increased in the MS group. …”
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    Analysis of Human Endogenous Retrovirus Expression in Multiple Sclerosis Plaques
  17. 6517
    “…CONCLUSION: The cleavage sites of HERV-K Gag were mapped and found to be highly conserved among HERV-K genomes. …”
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    Characterization of the human endogenous retrovirus K Gag protein: identification of protease cleavage sites
  18. 6518
    “…Human endogenous retroviruses (HERVs), remnants of ancient germ-line infections with exogenous retroviruses, are estimated to comprise up to 8% of human genome. …”
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    Endogenous Retroviruses as Targets for Antitumor Immunity in Renal Cell Cancer and Other Tumors
  19. 6519
    por Gao, Yuan, Yu, Xiao-Fang, Chen, Ting
    Publicado 2021
    “…In addition, this review focuses on the dual opposing effects of HERVs in cancer. HERVs can suppress cancer via immune activation; however, they can also promote cancer. …”
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    Human endogenous retroviruses in cancer: Expression, regulation and function
  20. 6520
    por Li, Yian, Zhang, Guojie, Cui, Jie
    Publicado 2022
    “…Human endogenous retroviruses (HERVs) are viral “fossils” in the human genome that originated from the ancient integration of exogenous retroviruses. …”
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    Online Artículo Texto
    Origin and Deep Evolution of Human Endogenous Retroviruses in Pan-Primates
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