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  1. 6541
    “…Human endogenous retroviruses (HERVs) are relics of ancestral infections and represent 8% of the human genome. …”
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    Enhanced Expression of Human Endogenous Retroviruses, TRIM28 and SETDB1 in Autism Spectrum Disorder
  2. 6542
    por Mao, Jian, Zhang, Qian, Cong, Yu-Sheng
    Publicado 2021
    “…It has been long thought that HERVs were “junk DNA”. However, it is now known that HERVs are involved in various biological processes through encoding proteins, acting as promoters/enhancers, or lncRNAs to affect human health and disease. …”
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    Human endogenous retroviruses in development and disease
  3. 6543
    “…Human endogenous retrovirus group E (HERV-E) elements are stably integrated into the human genome, transmitted vertically in a Mendelian manner, and are endowed with transcriptional activity as alternative promoters or enhancers. …”
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    Human Endogenous Retrovirus Group E and Its Involvement in Diseases
  4. 6544
    “…Background: Placenta shows high transcription levels of human endogenous retroviruses (HERVs) that are overexpressed during embryonic and fetal development. …”
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    Human Endogenous Retroviruses Are Preferentially Expressed in Mononuclear Cells From Cord Blood Than From Maternal Blood and in the Fetal Part of Placenta
  5. 6545
    “…The results showed higher levels of HERV-W, HERV-K, Syn-1, and ASCT-1/2 in KD, MIS-C, and COV patients, while higher levels of Syn-2 and MFSD2A were found only in MIS-C patients. …”
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    Preliminary Evidence of the Differential Expression of Human Endogenous Retroviruses in Kawasaki Disease and SARS-CoV-2-Associated Multisystem Inflammatory Syndrome in Children
  6. 6546
    “…HERV involvement in different types of cancer has already been thoroughly documented. …”
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    Differential expression analysis of human endogenous retroviruses based on ENCODE RNA-seq data
  7. 6547
    “…HERVs may activate the interferon (IFN) signaling pathway by a viral mimicry process to enhance antitumor immune responses. …”
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    Human Endogenous Retroviruses in Clear Cell Renal Cell Carcinoma: Biological Functions and Clinical Values
  8. 6548
    “…To identify active HERV-W loci, we cloned the HERV-W specific RT-PCR products, sequenced the cDNA clones and assigned the sequences to HERV-W loci. …”
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    Expression of Human Endogenous Retrovirus-W Including Syncytin-1 in Cutaneous T-Cell Lymphoma
  9. 6549
    “…While no replication-competent HERVs have been recognized, some retain up to three of four intact ORFs. …”
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    Classification and characterization of human endogenous retroviruses; mosaic forms are common
  10. 6550
    “…Human endogenous retroviruses (HERVs) are usually severely mutated, yet some coding-competent HERVs exist. …”
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    A human endogenous retrovirus encoded protease potentially cleaves numerous cellular proteins
  11. 6551
    “…The HML2 subfamily of HERV-K (henceforth HERV-K) represents the most recently endogenized retrovirus in the human genome. …”
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    Human Endogenous Retrovirus K Rec Forms a Regulatory Loop with MITF that Opposes the Progression of Melanoma to an Invasive Stage
  12. 6552
    “…We found that HERVs were transcribed in a cell type-specific manner and different HERV families were associated with diverse biological effects. …”
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    Single-cell RNA sequencing highlights the functional role of human endogenous retroviruses in gallbladder cancer
  13. 6553
    “…RESULTS: We identify differentially expressed genes and differentially expressed HERVs in Alzheimer’s disease patients. Differentially expressed HERVs are scattered throughout the genome; many of them are members of the HERV-K superfamily. …”
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    Locus specific endogenous retroviral expression associated with Alzheimer’s disease
  14. 6554
    “…Human endogenous retrovirus-H (HERV-H) is implicated in leukaemias and lymphomas, but the precise molecular mechanism underlying HERV-mediated carcinogenesis remains unknown. …”
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    Prevalence of human endogenous retroviral element associates with Hodgkin's lymphoma incidence rates()
  15. 6555
    “…Abnormal activation of human endogenous retroviruses (HERVs) has been associated with several diseases such as cancer, autoimmunity, and neurological disorders. …”
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    Human Endogenous Retrovirus K in the Crosstalk Between Cancer Cells Microenvironment and Plasticity: A New Perspective for Combination Therapy
  16. 6556
    “…HERVs comprise 8% of the human genome and are critical for several physiological activities. …”
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    Human endogenous retroviruses and the inflammatory response: A vicious circle associated with health and illness
  17. 6557
    “…The most recent class to invade the human genome is the HERV-K(HML-2) (HERV-K) family. Approximately 90 HERV-K proviruses and many smaller elements have been identified to date in the human genome. …”
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    Human endogenous retrovirus-K mRNA expression and genomic alignment data in hepatoblastoma
  18. 6558
    “…No studies explored the expression of HERVs, TRIM28, and SETDB1 in allergic patients. METHODS: We assessed, through a polymerase chain reaction real time Taqman amplification assay, the transcription levels of pol genes of HERV‐H, HERV‐K, HERV‐W, and of env genes of SYN1 and SYN2, as well as of TRIM28 and SETDB1 in whole blood from 32 children with IgE‐mediated food allergy, 19 with food protein‐induced enterocolitis syndrome (FPIES), and in healthy control children. …”
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    Enhanced expression of endogenous retroviruses and of TRIM28 and SETDB1 in children with food allergy
  19. 6559
    “…The HERV-K-MEL antigen is encoded by a pseudo-gene incorporated in the HERV-K env-gene. …”
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    Human endogenous retroviruses and cancer prevention: evidence and prospects
  20. 6560
    “…This difference is not solely due to global hypomethylation in placenta, since two general measures of methylation levels of HERV-E and HERV-K LTRs suggest only 10–15% lower overall HERV methylation in placenta compared to blood. …”
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    Widely variable endogenous retroviral methylation levels in human placenta
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