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  1. 6941
    “…The resulting de-repression of both cytokines and HERVs can be reversed with the PADI-inhibitor Cl-amidine. …”
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    Citrullination of Histone H3 Interferes with HP1-Mediated Transcriptional Repression
  2. 6942
    por Katoh, Iyoko, Kurata, Shun-ichi
    Publicado 2013
    “…In contrast, almost all of the human endogenous retroviruses (HERVs) originating from ancient infectious retroviruses lost their infectivity and transposing activity at various times before the human-chimpanzee speciation (∼6 million years ago), and no known HERV is presently infectious. …”
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    Association of Endogenous Retroviruses and Long Terminal Repeats with Human Disorders
  3. 6943
    “…TRIM28 and SETDB1 participate in the epigenetic regulation of genes involved in the immune response, including IFNs and HERVs. No study has explored the expression of HERVs, TRIM28, and SETDB1 during RSV bronchiolitis. …”
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    Expressions of Type I and III Interferons, Endogenous Retroviruses, TRIM28, and SETDB1 in Children with Respiratory Syncytial Virus Bronchiolitis
  4. 6944
    “…TRIM28 and SETDB1 regulate the transcription of multiple genes involved in the immune response as well as of human endogenous retroviruses (HERVs). Exogenous viral infections can trigger the activation of HERVs, which in turn can induce inflammatory and immune reactions. …”
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    COVID-19 in Children: Expressions of Type I/II/III Interferons, TRIM28, SETDB1, and Endogenous Retroviruses in Mild and Severe Cases
  5. 6945
    “…Part of it could lie in repetitive sequences, as those corresponding to human Endogenous Retroviruses (HERVs). Retrovirus-like particles were isolated from MS patients and the genome of the MS-associated retrovirus (MSRV) was the founder of the HERV-W family. …”
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    Multiple sclerosis retrovirus-like envelope gene: Role of the chromosome 20 insertion
  6. 6946
    “…Human endogenous retroviruses (HERVs), which are critical to normal embryologic development and downregulated during normal maturation, have been implicated in a variety of cancers. …”
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    Endogenous Retroviral Elements in Human Development and Central Nervous System Embryonal Tumors
  7. 6947
    “…The possibility that retroviruses play a role in multiple sclerosis (MS) has long been considered; accumulating findings suggest this to be most likely in the form of human endogenous retroviruses (HERVs). A genetic test series of fifty endogenous retroviral loci for association with MS in Danes showed SNP markers near a specific endogenous retroviral locus, HERV-Fc1 located on the X-chromosome, to be positive. …”
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    Endogenous retroviruses and multiple sclerosis–new pieces to the puzzle
  8. 6948
    “…The most recently integrated includes human ERV-K (HERV-K) where several envelope (env) sequences remain intact. …”
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    Reconstruction of the cell entry pathway of an extinct virus
  9. 6949
    “…Human endogenous retroviruses (HERVs) have evolved from exogenous retroviruses and account for approximately 8% of the human genome. …”
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    Molecular mechanisms of syncytin-1 in tumors and placental development related diseases
  10. 6950
    “…The effects are strongest for HERV-H and suggest that the HERV-H transcriptome has recently evolved under the influence of directional selection. …”
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    Orthologous endogenous retroviruses exhibit directional selection since the chimp-human split
  11. 6951
    “…We demonstrate that HERV-K(HML2) Env effectively activates the ERK1/2 pathway in our experimental setting and that this activation depends on the Env cytoplasmic tail. …”
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    A human endogenous retrovirus-derived gene that can contribute to oncogenesis by activating the ERK pathway and inducing migration and invasion
  12. 6952
    “…In critically ill patients, higher HERV-K levels were associated with early mortality (within 14 days of diagnosis) in the intensive care unit. …”
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    Human endogenous retrovirus K in the respiratory tract is associated with COVID-19 physiopathology
  13. 6953
    “…This study is the first report on the full-length HERV-K assembled genomes in the Thai population. …”
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    Metagenomic analysis of viral genes integrated in whole genome sequencing data of Thai patients with Brugada syndrome
  14. 6954
    “…Moreover, NS workers retained different methylation levels for ERVFRD-1 (p-value = 0.0274), HERV-L (p-value = 0.0377), and HERV-P (p-value = 0.0140) elements, and for BIRC2 (p-value = 0.0460), FLRT3 (p-value = 0.0422), MIG6 (p-value = 0.0085), and SIRT1 (p-value = 0.0497) genes. …”
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    Association between night shift work and methylation of a subset of immune-related genes
  15. 6955
    “…The long terminal repeats (LTRs) of human endogenous retroviruses (HERVs) are distributed throughout the human genome and provide favorable conditions to regulate the expression of their adjacent genes. …”
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    p53 Binding Sites in Long Terminal Repeat 5Hs (LTR5Hs) of Human Endogenous Retrovirus K Family (HML-2 Subgroup) Play Important Roles in the Regulation of LTR5Hs Transcriptional Activity
  16. 6956
    “…Knockdown of HERV-K also increased DTG resistance of BT-20 cells. …”
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    Dolutegravir Inhibits Proliferation and Motility of BT-20 Tumor Cells Through Inhibition of Human Endogenous Retrovirus Type K
  17. 6957
    “…However expression of human endogenous retroviruses (HERVs) was higher than in wild‐type hESCs, and there was also a reduced level of trimethylation of histone H3 on lysine 9 at HERV loci. …”
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    IFITM1 suppresses expression of human endogenous retroviruses in human embryonic stem cells
  18. 6958
    por Douville, Renée N., Nath, Avindra
    Publicado 2017
    “…Enhanced neuronal HERV-K levels were observed in the majority of HIV-infected individuals, and to a higher degree in brain tissue marked by HIV replication. …”
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    Human Endogenous Retrovirus-K and TDP-43 Expression Bridges ALS and HIV Neuropathology
  19. 6959
    por Ryan, F.P
    Publicado 2011
    “…There is growing evidence that the env genes of two or more human endogenous retroviruses (HERVs) of the W family are contributing to the inflammatory processes, and thus to the pathogenesis, of multiple sclerosis (MS). …”
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    Human Endogenous Retroviruses in Multiple Sclerosis: Potential for Novel Neuro-Pharmacological Research
  20. 6960
    “…Mobile genetic elements, such as human endogenous retroviruses (HERVs), produce proteins that regulate brain cell functions and synaptic transmission and have been implicated in the etiology of neurological and neurodevelopmental psychiatric disorders. …”
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    Human endogenous retroviral protein triggers deficit in glutamate synapse maturation and behaviors associated with psychosis
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