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  1. 7261
    “…The latter is especially important for HERVs, which may represent the molecular link between environmental triggers and critical immune genes. …”
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    Viral Infections and Systemic Lupus Erythematosus: New Players in an Old Story
  2. 7262
    “…This changes transcription of flanking endogenous retroviral sequences (HERVs), involved in an evolutionary conserved (epi) genomic protective response against viral infections. …”
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    Echinacea purpurea (L.) Moench treatment of monocytes promotes tonic interferon signaling, increased innate immunity gene expression and DNA repeat hypermethylated silencing of endogenous retroviral sequences
  3. 7263
    “…By reviewing some studies about the function of CDK and CIKs in cells infected with oncoviruses, such as HPV, HTLV, HERV, EBV, KSHV, HBV and HCV, we reviewed the mechanisms of different onco-proteins which could deregulate the cell cycle proteins.…”
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    Cyclin-dependent kinases and CDK inhibitors in virus-associated cancers
  4. 7264
    “…The long-term overproduction of IFN-γ in retroviral infections, such as the human immunodeficiency virus (HIV), human T-lymphotropic virus type 1 (HTLV-1), and human endogenous retroviruses (HERVs), resulting in inflammation, may cause neuronal damage. …”
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    The role of IFN-γ production during retroviral infections: an important cytokine involved in chronic inflammation and pathogenesis
  5. 7265
    “…One basic unit comprises an expressed Mamu-B gene, adjacent to an HERV16 copy closely linked to MIB. The second type of duplicon comprises a Mamu-B (pseudo)gene, linked to a truncated HERV16 structure lacking its MIB segment. …”
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    Compound Evolutionary History of the Rhesus Macaque Mhc Class I B Region Revealed by Microsatellite Analysis and Localization of Retroviral Sequences
  6. 7266
    por Krone, Bernd, Grange, John M.
    Publicado 2011
    “…A postulated aetiological factor in MS, associated with altered vitamin D metabolism and abnormal HERV expression, is a long-lasting disturbed redox regulation in the biosynthesis of a melanoma-like melanin pigment. …”
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    Paradigms in multiple sclerosis: time for a change, time for a unifying concept
  7. 7267
    “…Overexpression of NRAS was sufficient to restore cellular proliferation, and MYC, a transcription factor downstream of NRAS, was bound to the HERV-K LTR significantly more in the absence of SMARCB1 expression in AT/RT cells. …”
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    SMARCB1 deletion in atypical teratoid rhabdoid tumors results in human endogenous retrovirus K (HML-2) expression
  8. 7268
    “…Human endogenous retrovirus (HERVs), originating from exogenous retroviral infections of germ cells millions of years ago, have the potential for human diseases. …”
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    Implication of human endogenous retrovirus W family envelope in hepatocellular carcinoma promotes MEK/ERK-mediated metastatic invasiveness and doxorubicin resistance
  9. 7269
    “…However, exogenous retroviruses could not be found in individuals with ALS which further reinforced the possibility of involvement of a human ERV (HERV). The first demonstration of the involvement of a HERV was the discovery of the activation of human endogenous retrovirus-K subtype HML-2 in the brains of individuals with ALS. …”
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    Retroviral Elements in Pathophysiology and as Therapeutic Targets for Amyotrophic Lateral Sclerosis
  10. 7270
    por Hothi, Parvinder, Cobbs, Charles
    Publicado 2023
    “…The most active human endogenous retrovirus K (HERV-K) subtype, HML-2, has been implicated as a driver of oncogenesis in several cancers. …”
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    The potential role of human endogenous retrovirus K in glioblastoma
  11. 7271
    por Camp, Faye A., Slansky, Jill E.
    Publicado 2021
    “…Here, we highlight various classes of cancer antigens, including self, neojunction-derived, human endogenous retrovirus (HERV)-derived, and somatic nucleotide variant (SNV)-derived antigens, and consider their utility in T cell-based immunotherapies. …”
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    Implications of Antigen Selection on T Cell-Based Immunotherapy
  12. 7272
    “…Human killer cell immunoglobulin-like receptor, three Ig domains and long cytoplasmic tail (KIR3DL3) is expressed on natural killer (NK) cells and is a newly identified inhibitory receptor for B7 family member HERV-H LTR-associating protein 2 (HHLA2). Here, we summarize the isolation and expansion of KIR3DL3(+) human NK cells, and in vitro functional characterization of in-house anti-KIR3DL3 monoclonal antibody (mAb). …”
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    Protocol for evaluating antitumor activity of KIR3DL3 blockade in an NK cell-based xenogeneic lung tumor model
  13. 7273
    “…One lineage of human endogenous retroviruses (HERVs), HERV-K(HML2), is upregulated in many cancers, some autoimmune/inflammatory diseases, and HIV-infected cells. …”
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    Unfixed Endogenous Retroviral Insertions in the Human Population
  14. 7274
    “…HIV(89.6) infection was also associated with activation of several human endogenous retroviruses (HERVs) and retrotransposons, of interest as possible novel antigens that could serve as vaccine targets. …”
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    Gene activity in primary T cells infected with HIV(89.6): intron retention and induction of genomic repeats
  15. 7275
    “…Results: RA patients exhibit a higher prevalence of humoral immune response against all tested peptides compared to HCs with a statically significant difference for MAP4027 (30.4% vs. 10.1%), BOLF (25.7% vs. 8.1%), RgpA (24.3% vs. 9.4%), HERV W-env (20.3% vs. 9.4%), and EBNA1 (18.9% vs. 9.4%) peptides. …”
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    Humoral Response to Microbial Biomarkers in Rheumatoid Arthritis Patients
  16. 7276
    “…BACKGROUND: The human HERV-W multicopy family includes a unique proviral locus, termed ERVWE1, whose full-length envelope ORF was preserved through evolution by the action of a selective pressure. …”
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    Natural history of the ERVWE1 endogenous retroviral locus
  17. 7277
    “…All known human-specific LTRs belong to the HERV-K (human ERV) family, the most active family in the human genome. …”
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    Endogenous Retroviruses and Human Evolution
  18. 7278
    por Fierz, Walter
    Publicado 2017
    “…A further link between HHV-6A and EBV involves their induction of expression of the human endogenous retrovirus HERV-K18-encoded superantigen. Such virally induced T-cell responses might secondarily also lead to local autoimmune phenomena. …”
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    Multiple sclerosis: an example of pathogenic viral interaction?
  19. 7279
    “…Overall, higher V-HLA immunogenicity was associated with smaller MS-HLA effect, with human herpes virus 3 (HHV3), JC human polyoma virus (JCV), HHV1, HHV4, HHV7, HHV5 showing the strongest association, followed by HHV8, HHV6A, and HHV6B (moderate association), and human endogenous retrovirus (HERV-W), HHV2, and human papilloma virus (HPV) (weakest association). …”
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    Negative association between multiple sclerosis immunogenetic profile and in silico immunogenicities of 12 viruses
  20. 7280
    “…We recently described that the autoimmune, central nervous system disease, multiple sclerosis (MS), is genetically associated with the human endogenous retroviral locus, HERV-Fc1, in Scandinavians. A number of dominant human genes encoding factors that restrict retrovirus replication have been known for a long time. …”
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    Restriction Genes for Retroviruses Influence the Risk of Multiple Sclerosis
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