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7281por Acton, Oliver, Grant, Tim, Nicastro, Giuseppe, Ball, Neil J., Goldstone, David C., Robertson, Laura E., Sader, Kasim, Nans, Andrea, Ramos, Andres, Stoye, Jonathan P., Taylor, Ian A., Rosenthal, Peter B.“…The HML2 (HERV-K) group constitutes the most recently acquired family of human endogenous retroviruses, with many proviruses less than one million years old. …”
Publicado 2019
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7282por Gonzalez Trujillo, Fernando, Parra Cortes, Karen, Álvarez Pareja, Yolima, Onate, Jose“…The increased expression of human endogenous retrovirus K (HERV-K) in the brain tissue of patients with ALS has been demonstrated, a finding that supports the relationship between the virus and this disease. …”
Publicado 2020
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7283“…Finally, we recommend the employment of systems biology approaches for future HERV research.…”
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7284por Glinsky, Gennadi V.“…Despite significant efforts, understanding of HERV’s roles in governance of genomic regulatory networks, their impacts on primate evolution and development of human-specific physiological and pathological phenotypic traits remains limited. …”
Publicado 2022
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7285por Brodziak, Andrzej, Ziółko, Ewa, Muc-Wierzgoń, Małgorzata, Nowakowska-Zajdel, Ewa, Kokot, Teresa, Klakla, Katarzyna“…This theory takes into account the existence in the human genome, since approximately 40 million years, of so-called human endogenous retroviruses (HERVs), which are transmitted to descendants “vertically” by the germ cells. …”
Publicado 2012
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7286“…Much of the evidence for pathogenicity implicates endogenous retroviruses (ERVs), a subset of TEs that entered the genome by retroviral infections of germline cells in our evolutionary ancestors and have since been passed down as a substantial fraction of the human genome. Human specific ERVs (HERVs) represent some of the youngest ERVs in the genome, and thus are presumed to retain greater function and resultant pathogenic potential.…”
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7287por Saha, Anjan K., Mourad, Mohamad, Kaplan, Mark H., Chefetz, Ilana, Malek, Sami N., Buckanovich, Ronald, Markovitz, David M., Contreras-Galindo, Rafael“…Quantitative reductions in centromeric core and pericentromeric markers (α-satellite units and HERV-K copies) were observed in neoplastic samples as compared to healthy counterparts. …”
Publicado 2019
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7288por Wu, Bowen, Gan, Yichao, Xu, Ying, Wu, Zhaoxing, Xu, Ganyu, Wang, Ping, Wang, Chen, Meng, Zhipeng, Li, Mengyuan, Zhang, Jiawei, Zhuang, Haifeng, Zhang, Xuzhao, Yang, Linlin, Li, Jinfan, Gan, Xiaoxian, Yu, Xiaofang, Huang, Wendong, Gu, Ying, Xu, Rongzhen“…We previously defined the HERV-K Np9 as a viral oncogene. Here we report the discovery of a novel oncogene, Np17, which is homologous to the viral Np9 gene and predominantly present in Hominoidea. …”
Publicado 2020
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7289por Kang, Byong H., Momin, Noor, Moynihan, Kelly D., Silva, Murillo, Li, Yingzhong, Irvine, Darrell J., Wittrup, K. Dane“…These results suggest the potential for effective prophylactic vaccination against analogous HERV-K env expressed in numerous human cancers.…”
Publicado 2021
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7290
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7291
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7292por Singh, Bhavya, Dopkins, Nicholas, Fei, Tongyi, Marston, Jez L., Michael, Stephanie, Reyes-Gopar, Helena, Curty, Gislaine, Heymann, Jonas J., Chadburn, Amy, Martin, Peter, Leal, Fabio E., Cesarman, Ethel, Nixon, Douglas F., Bendall, Matthew L.“…Our findings demonstrate unique human endogenous retrovirus (HERV) signatures in the GC and lymphoma subtypes whose activity can be used in combination with gene expression to define B-cell lineage in lymphoid malignancies, highlighting the potential of retrotranscriptomic analyses as a tool in lymphoma classification, diagnosis, and the identification of novel treatment groups.…”
Publicado 2023
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7293por Guo, Caiwei, Jeong, Hyun-Hwan, Hsieh, Yi-Chen, Klein, Hans-Ulrich, Bennett, David A., De Jager, Philip L., Liu, Zhandong, Shulman, Joshua M.“…In addition, we detect Tau-associated, active chromatin signatures at multiple HERV-Fc1 genomic loci. To determine whether Tau is sufficient to induce TE activation, we profile retrotransposons in Drosophila expressing human wild-type or mutant Tau throughout the brain. …”
Publicado 2018
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7294“…Expression of either Drosophila mdg4-ERV (gypsy) or the human ERV, HERV-K (HML-2) are each sufficient to stimulate cytoplasmic aggregation of human TDP-43. …”
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7295“…The envelope proteins of HERV-W and -FRD (human endogenous retrovirus-W and -FRD), syncytin-1 and syncytin-2, are mainly distributed in the placenta, and play important roles in the development of the placenta. …”
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7296Publicado 1992“…SINE-R.C2 is a member of a previously described large retroposon family of the human genome, apparently derived from the human endogenous retrovirus, (HERV) K10, which is homologous to the mouse mammary tumor virus.…”
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7297“…In this review, the target tumor antigens employed in recent years in the development of therapeutic cancer vaccine strategies are described, along with potential new classes of tumor antigens such as the human endogenous retroviral elements (HERVs), unconventional antigens, and/or heteroclitic peptides.…”
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7298Association of Viral Infection With the Development and Pathogenesis of Systemic Lupus Erythematosus“…Human endogenous retroviruses (HERVs) may put patients at a genetic predisposition to SLE, while the Epstein-Barr virus (EBV) may play a role as an environmental factor that triggers the development of SLE. …”
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7299por Lee, Du Hyeong, Bae, Woo Hyeon, Ha, Hongseok, Park, Eun Gyung, Lee, Yun Ju, Kim, Woo Ryung, Kim, Heui-Soo“…Human endogenous retrovirus (HERV) families are widely distributed in human chromosomes at a ratio of 8%. …”
Publicado 2022
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7300por Attig, Jan, Pape, Judith, Doglio, Laura, Kazachenka, Anastasiya, Ottina, Eleonora, Young, George R., Enfield, Katey S.S., Aramburu, Iker Valle, Ng, Kevin W., Faulkner, Nikhil, Bolland, William, Papayannopoulos, Venizelos, Swanton, Charles, Kassiotis, George“…Increased levels and diversity of human endogenous retrovirus (HERV) transcription characterize most cancer types and are linked with disease outcomes. …”
Publicado 2023
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