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  1. 141
    por Hegyi, Hedi
    Publicado 2013
    “…We suggest GABBR1, GABA receptor B1 implicated in schizophrenia based on a HERV-W LTR in the regulatory region of GABBR1. Our hypothesis is supported by: (i) GABBR1 is in the 6p22 genomic region most often implicated in schizophrenia; (ii) microarray studies found that only presynaptic pathway-related genes, including GABA receptors, have altered expression in schizophrenic patients and (iii) it explains how HERV-W elements, expressed in schizophrenia, play a role in the disease: by altering the expression of GABBR1 via a long terminal repeat that is also a regulatory element to GABBR1. …”
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    GABBR1 has a HERV-W LTR in its regulatory region – a possible implication for schizophrenia
  2. 142
    “…In this study, we investigated the abundance and distribution of Herves TE in An. gambiae s.s. from Cameroon and four islands in the Gulf of Guinea, in order to determine their genetic structure. …”
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    New Insights into the Population Structure of Anopheles gambiae s.s. in the Gulf of Guinea Islands Revealed by Herves Transposable Elements
  3. 143
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    Human endogenous retrovirus K (HERV-K) transcripts detection in babies exposed to HIV-1 during pregnancy
  4. 144
    “…Human endogenous retrovirus (HERV-K (HML-2)) proviruses are among the few endogenous retroviral elements in the human genome that retain coding sequence. …”
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    Differential Expression of HERV-K (HML-2) Proviruses in Cells and Virions of the Teratocarcinoma Cell Line Tera-1
  5. 145
    “…More than eight percent of the human genome consists of human endogenous retroviruses (HERVs). Typically, the expression of HERVs is repressed, but varying activities of HERVs have been observed in diseases ranging from cancer to neuro-degeneration. …”
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    WebHERV: A Web Server for the Computational Investigation of Gene Expression Associated With Endogenous Retrovirus-Like Sequences
  6. 146
    “…Overexpression of the Human endogenous retrovirus W (HERV-W) group of inherited retroviruses has been consistently linked with Multiple Sclerosis (MS). …”
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    Differential Expression of HERV-W in Peripheral Blood in Multiple Sclerosis and Healthy Patients in Two Different Ethnic Groups
  7. 147
    “…However, the exact biological mechanisms induced by HERVs are still poorly understood. We have previously shown that several HERVs of the HERV-K (HML-2) family are strongly transcribed in the peripheral blood mononuclear cells (PBMC) derived from young and old individuals. …”
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    Effect of aging on the transcriptomic changes associated with the expression of the HERV-K (HML-2) provirus at 1q22
  8. 148
    “…To investigate the evolutionarily conserved mechanism behind the transcriptional activity of retrotransposons, we generated a transgenic worm model driving green fluorescent protein (GFP) expression using Human endogenous retroviruses (HERV)-K LTR as a promoter. The promoter activity of HERV-K LTR was robust and fluorescence was observed in various tissues throughout the developmental process. …”
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    Human Endogenous Retrovirus K (HERV-K) can drive gene expression as a promoter in Caenorhabditis elegans
  9. 149
    “…Among possible relevant HERVs, the HERV-K supergroup is of particular interest, including some of the oldest (HML5) as well as youngest (HML2) integrations. …”
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    HERV-K(HML7) Integrations in the Human Genome: Comprehensive Characterization and Comparative Analysis in Non-Human Primates
  10. 150
    “…Human endogenous retroviruses (HERVs) are remnants of infections that took place several million years ago and represent around 8% of the human genome. …”
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    Identification of inflammatory subgroups of schizophrenia and bipolar disorder patients with HERV-W ENV antigenemia by unsupervised cluster analysis
  11. 151
    “…In PAECs, HERV-K dUTPase requires TLR4-myeloid differentiation primary response–88 to increase IL-6 and SNAIL/SLUG, and HERV-K dUTPase interaction with melanoma cell adhesion molecule (MCAM) is necessary to upregulate VCAM1. …”
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    Monocyte-released HERV-K dUTPase engages TLR4 and MCAM causing endothelial mesenchymal transition
  12. 152
    “…HERV expression inversely correlated with loci-specific DNA methylation. …”
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    Differential expression of an endogenous retroviral element [HERV-K(HML-6)] is associated with reduced survival in glioblastoma patients
  13. 153
    “…Human endogenous retroviruses (HERVs) represent approximately 8% of our genome. …”
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    Activation of LTRs from Different Human Endogenous Retrovirus (HERV) Families by the HTLV-1 Tax Protein and T-Cell Activators
  14. 154
    “…BACKGROUND: Up-regulation of the most abundant H family human endogenous retrovirus (HERV-H), especially env-related transcripts, correlates with colon cancer. …”
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    Expression Patterns of Non-Coding Spliced Transcripts from Human Endogenous Retrovirus HERV-H Elements in Colon Cancer
  15. 155
    “…Increased HERV expression and antibodies to HERV antigens have been found in various autoimmune diseases. …”
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    Role of the Human Endogenous Retrovirus HERV-K18 in Autoimmune Disease Susceptibility: Study in the Spanish Population and Meta-Analysis
  16. 156
    por Agoni, Lorenzo, Lenz, Jack, Guha, Chandan
    Publicado 2013
    “…Human endogenous retrovirus K (HERV-K) is the most intact retrovirus in the human genome. …”
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    Variant Splicing and Influence of Ionizing Radiation on Human Endogenous Retrovirus K (HERV-K) Transcripts in Cancer Cell Lines
  17. 157
    “…RESULTS: Prevalence of endogenous retroviral sequences HERV-K113 and HERV-K115 was determined in the Polish population. …”
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    Frequency of Human Endogenous Retroviral Sequences (HERV) K113 and K115 in the Polish Population, and Their Effect on HIV Infection
  18. 158
    “…METHODS: In the present study we examined the humoral immune response against human endogenous retrovirus-K (HERV-K) proteins and the cutaneous expression levels of multiple HERV-K genes in psoriasis patients and healthy controls. …”
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    Diminished humoral responses against and reduced gene expression levels of human endogenous retrovirus-K (HERV-K) in psoriasis
  19. 159
    “…BACKGROUND: Human endogenous retroviruses of the HERV-K(HML-2) group have been associated with the development of tumor diseases. …”
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    HERV-K(HML-2) rec and np9 transcripts not restricted to disease but present in many normal human tissues
  20. 160
    “…In time, HERVs accumulated mutations that compromised their coding capacity. …”
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    Contribution of type W human endogenous retroviruses to the human genome: characterization of HERV-W proviral insertions and processed pseudogenes
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