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1101“…The C-index of the predicted nomogram was 0.813 and a high C-index value of 0.846 could still be achieved in the external validation of TCGA. …”
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1102por Chen, Peng, Yang, Xian, Wang, Peiyuan, He, Hao, Chen, Yujie, Yu, Lingfeng, Fang, Huipeng, Wang, Feng, Huang, Zhijian“…CONCLUSIONS: This study discovered that SARS-CoV-2-infected cancer patients might experience changes in their tumor environment as a result of cGAS, making patients with tumors expressing high cGAS more susceptible to COVID-19 and possibly a worsening prognosis. …”
Publicado 2023
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1103por Dongxiang, Wen, Liting, Liu, Yujing, Liang, Meijuan, Luo, Shanshan, Guo, Longbin, Xiong, Yanzhou, Chen, Meiling, Chen, Kang, Ning, Haiqiang, Mai, Linquan, Tang, Qiuyan, Chen“…This novel model showed good discrimination with a high C-index (0.752, 95%CI: 0.714–0.790). In addition, the calibration curves showed good agreement between the predicted probabilities and actual observations and decision curve analysis (DCA) suggested that the nomogram was useful for clinical decision-making. …”
Publicado 2022
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1104por Hurkmans, Daan P, Jensen, Christina, Koolen, Stijn L W, Aerts, Joachim, Karsdal, Morten Asser, Mathijssen, Ron H J, Willumsen, Nicholas“…High baseline PRO-C3 was also independently related to worse OS (HR=2.08, 95% CI=1.06 to 4.09, p=0.035), whereas a high C3M/PRO-C3 ratio was related to improved OS (HR=0.42, 95% CI=0.20 to 0.90, p=0.025). …”
Publicado 2020
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1105por Schmidt, Ulrike, Heller, Gerwin, Timelthaler, Gerald, Heffeter, Petra, Somodi, Zsolt, Schweifer, Norbert, Sibilia, Maria, Berger, Walter, Csiszar, Agnes“…BACKGROUND: Gene amplification of MET, which encodes for the receptor tyrosine kinase c-MET, occurs in a variety of human cancers. High c-MET levels often correlate with poor cancer prognosis. …”
Publicado 2021
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1106por Weil, Patrick Philipp, Hentschel, Jacqueline, Schult, Frank, Pembaur, Anton, Ghebremedhin, Beniam, Mboma, Olivier, Heusch, Andreas, Reuter, Anna-Christin, Müller, Daniel, Wirth, Stefan, Aydin, Malik, Jenke, Andreas C. W., Postberg, Jan“…In order to expand the diagnostic bandwidth for non-routine questions, particularly for the reliable discrimination between negative and false-negative specimens associated with high C(T) values, we combined the RT-qPCR workflow with subsequent pyrosequencing of a S-gene amplicon. …”
Publicado 2021
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1107por Derbel, A., Guermazi, M., El Moctar, E.M., Jemal, A., Damak, C., Mouna, S., Ben Salah, R., Frikha, F., Marzouk, S., Bahloul, Z.“…Biological tests showed anemia (hemoglobin =8.6 g/dl), accelerated erythrocyte sedimentation rate (65 mm H1) ; high C-reactive protein(119 mg/l)d biological myolysis and cytolydid (Creatinin kinase = 1052 U/l, LDH = 478 AST/ALT 238 U/l/119 U/l). …”
Publicado 2021
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1108por Morgan, Robert D., Ferreras, Cristina, Peset, Isabel, Avizienyte, Egle, Renehan, Andrew G., Edmondson, Richard J., Murphy, Alexander D., Nicum, Shibani, Van Brussel, Thomas, Clamp, Andrew R., Lambrechts, Diether, Zhou, Cong, Jayson, Gordon C.“…CONCLUSIONS: In bevacizumab-treated women diagnosed with EOC, high c-MET/VEGFR-2 co-localisation on tumour tissue and the VEGFR-2 rs2305945 G/G variant, which may be biologically related, were associated with worse survival outcomes. …”
Publicado 2022
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1109por Zhou, Tianxing, Xie, Yongjie, Hou, Xupeng, Bai, Weiwei, Li, Xueyang, Liu, Ziyun, Man, Quan, Sun, Jingyan, Fu, Danqi, Yan, Jingrui, Zhang, Zhaoyu, Wang, Yifei, Wang, Hongwei, Jiang, Wenna, Gao, Song, Zhao, Tiansuo, Chang, Antao, Wang, Xiuchao, Sun, Hongxia, Zhang, Xiufeng, Yang, Shengyu, Huang, Chongbiao, Hao, Jihui, Liu, Jing“…Moreover, patients with PDAC had significant survival benefits from treatment with irbesartan plus a standard chemotherapy regimen in two-center retrospective clinical cohorts and patients with high c-Jun expression exhibited a better response to combination chemotherapy. …”
Publicado 2023
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1110“…Patients were divided into three arbitrary groups according to their cycle threshold (C(T)) values obtained at admission as high (C(T) < 25.0), medium (C(T) between 25.0 and 30.0), and low (C(T) > 30.0) viral load. …”
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1111por Wang, Weina, Meng, Xinxuan, Liu, Jiaojiao, Lou, Xiaowei, Zhang, Ping, He, Peipei, Chen, Jianghua, Yuan, Jing“…A nomogram was developed according to the results of model performance. The model achieved high C-indexes of 0.843 in the training set, 0.841 and 0.829 in the internal and external validation sets, respectively, and had a well-fitted calibration curve. …”
Publicado 2023
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1112por Gu, Yuanzhuo, Ji, Fubo, Liu, Niya, Zhao, Yongzhi, Wei, Xiyang, Hu, Shiyuan, Jia, Wei, Wang, Xin Wei, Budhu, Anuradha, Ji, Juling, Zhao, Bin, Roessler, Stephanie, Zheng, Xin, Ji, Junfang“…Meanwhile, c-Myc suppressed miR-192-5p transcription, ensuring a low-miR-192-5p/high-c-Myc loop to maintain hyperglycolysis. Moreover, over-produced lactic acid from hyperglycolytic HCC cells stimulated the ERK phosphorylation of co-cultured LX2 and THP1 non-tumor cells partially via NDRG3 and MCT1, which in turn promoted cell malignancy and stemness of HCC cells. …”
Publicado 2020
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1113“…BACKGROUND: The risk of sustaining a contra-lateral anterior cruciate ligament (C-ACL) injury after primary unilateral ACL injury is high. C-ACL injury often contributes to a further decline in function and quality of life, including failure to return to sport. …”
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1114por Stelwagen, Johannes, Meuleman, Andrea T., Lubberts, Sjoukje, Steursma, Gerrie, Kruyt, Lara M., Donkerbroek, Jan W., Meijer, Coby, Walenkamp, Annemiek M. E., Lefrandt, Joop D., Rakers, Sandra E., Huitema, Rients B., de Jong, Marianne A. A., Wiegman, Erwin M., van den Bergh, Alfons C. M., de Jong, Igle J., van Rentergem, Joost A. Agelink, Schagen, Sanne B., Nuver, Janine, Gietema, Jourik A.“…In univariate analysis, the presence of hypogonadism (β −1.50, p < 0.01), high c-PWV (β −0.35, p = 0.09), and high AGEs (β −1.27, p = 0.02) were associated with lower cognitive scores, while only AGEs (β −1.17, p = 0.03) remained a significant predictor in multivariate analysis (Model R2 0.31, p < 0.01). …”
Publicado 2021
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1115por Cavalli, Giulio, Larcher, Alessandro, Tomelleri, Alessandro, Campochiaro, Corrado, Della-Torre, Emanuel, De Luca, Giacomo, Farina, Nicola, Boffini, Nicola, Ruggeri, Annalisa, Poli, Andrea, Scarpellini, Paolo, Rovere-Querini, Patrizia, Tresoldi, Moreno, Salonia, Andrea, Montorsi, Francesco, Landoni, Giovanni, Castagna, Antonella, Ciceri, Fabio, Zangrillo, Alberto, Dagna, Lorenzo“…IL-6 inhibition was effective in a subgroup of patients with markedly high C-reactive protein concentrations, whereas both IL-1 and IL-6 inhibition were effective in patients with low lactate dehydrogenase concentrations. …”
Publicado 2021
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1116por Kaluzhskaya, Ksenia V., Polyakov, Yuri Yu., Baryakh, Elena A., Gemdzhian, Eduard G., Misyurina, Elena N., Zhelnova, Evgenia I., Yatskov, Konstantin V., Kochneva, Olga L., Samsonova, Inna V., Lysenko, Mariana A., Ivanova, Diana D., Chudnova, Tatyana S., Fedorenko, Denis A.“…Results: Most pts had moderate to severe lung disease (CT severity scores were 2, 3, and 4 in 29 (38.2%), 17 (22.5%), and 8 (10%) patients, respectively); 55% of patients had high C-reactive protein and procalcitonin (above 0.5 ng/mL); lactate dehydrogenase (mean 395.7 U/L) and D-dimer (mean 2533.8) levels were significantly elevated. …”
Publicado 2021
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1117por Cao, Wan-Ting, Huang, Rong, Liu, Shan, Fan, Yi-Hong, Xu, Mao-Sheng, Xu, Yi, Ni, Hui“…At week 54, low ITL (OR = 0.466, 95%CI: 0.247-0.877, P < 0.01) and high C-reactive protein (CRP) level (OR = 1.590, 95%CI: 1.007-2.510, P < 0.01) increased the risk of endoscopic activity at week 108. …”
Publicado 2022
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1118“…It can be transformed to a single-layer and highly c-oriented AFI membrane of hexagonal prisms if the structure-directing matrix is replaced by a thin layer of low molecular weight (LMW) chitosan. …”
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1119por Nakano, Tomomi, Nakamura, Shin-ichi, Yamamoto, Akihiko, Takahashi, Motohide, Une, Yumi“…Similar outbreaks could be prevented by vaccinating all monkeys, disinfecting housing areas/play equipment, replacing highly C. tetani–contaminated soil, and conducting epidemiologic surveys.…”
Publicado 2012
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1120“…[Image: see text] The first catalytic, highly C3-selective, stereosepecific ring-opening reaction of 2,3-epoxy alcohols and 2,3-epoxy sulfonamides has been accomplished. …”
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