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61por Inoue, Naoko, Nakao, Harumi, Migishima, Rika, Hino, Toshiaki, Matsui, Minoru, Hayashi, Fumihiko, Nakao, Kazuki, Manabe, Toshiya, Aiba, Atsu, Inokuchi, Kaoru“…BACKGROUND: The formation of long-term memory (LTM) and the late phase of long-term potentiation (L-LTP) depend on macromolecule synthesis, translation, and transcription in neurons. vesl-1S (VASP/Ena-related gene upregulated during seizure and LTP, also known as homer-1a) is an LTP-induced immediate early gene. …”
Publicado 2009
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62por Bertaso, Federica, Roussignol, Gautier, Worley, Paul, Bockaert, Joël, Fagni, Laurent, Ango, Fabrice“…Interestingly, a physical link exists between these receptors through a Homer-Shank multi-protein scaffold that can be disrupted by the immediate early gene, Homer1a. …”
Publicado 2010
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63The TRPC2 channel forms protein-protein interactions with Homer and RTP in the rat vomeronasal organ“…Development of an in vitro expression system for the transient receptor potential 2 channel (TRPC2), which establishes the first electrical signal in the pheromone transduction pathway, led to the discovery of two protein partners that couple with the channel in the native VNO. RESULTS: Homer family proteins were expressed in both male and female adult VNO, particularly Homer 1b/c and Homer 3. …”
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64por Masic, IzetEnlace del recurso
Publicado 2016
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65“…Homer signaling can exert either positive or negative effects during such insults, depending on the specific subtype of Homer protein. …”
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68por Bahgaat, Naglaa K.“…Statistical analysis was performed by varying the systems through comparison to determine the optimal approaches based on the Hybrid Optimization Model for Electrical Renewables software (HOMER).…”
Publicado 2023
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69“…We studied the role of Homer1 gene products on the presence of synaptic Ca(2+)-permeable AMPA receptors (AMPARs) and long-term potentiation (LTP) generation in hippocampal CA1 pyramidal neurons, using mice either lacking all Homer1 isoforms (Homer1 KO) or overexpressing the immediate early gene (IEG) product Homer1a (H1aTG). …”
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70por Paquet, Maryse, Ribeiro, Fabiola M, Guadagno, Jennifer, Esseltine, Jessica L, Ferguson, Stephen SG, Cregan, Sean P“…Moreover, the disruption of Homer protein interactions with mGluR5 also reduced astrocyte apoptosis. …”
Publicado 2013
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71por Bakshi, Kalindi, Parihar, Raminder, Goswami, Satindra K., Walsh, Melissa, Friedman, Eitan, Wang, Hoau-Yan“…In support, phosphatase treatment of prenatal cocaine-exposed tissues restores whereas PKC-mediated phosphorylation of saline-treated synaptic membrane attenuates mGluR1 coupling to both Gq/11 and Homer1. Expression of mGluR1, Homer1 or Gα proteins was not altered by prenatal cocaine exposure. …”
Publicado 2014
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72“…The constitutively expressed protein Homer1b/c participates in delivering and anchoring metabotropic glutamate receptors in neurons. …”
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73por Gutierrez-Mecinas, Maria, Kuehn, Emily D., Abraira, Victoria E., Polgár, Erika, Watanabe, Masahiko, Todd, Andrew J.“…We also examined several populations of glutamatergic axons and found that most boutons were in contact with at least one Homer punctum. These results suggest that Homer antibodies can be used to reveal the great majority of glutamatergic synapses without antigen retrieval. …”
Publicado 2016
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74“…During wake, long-form Homer proteins tether mGluR1/5 to IP3R and to the post-synaptic density (PSD). …”
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75por Urdánoz-Casado, Amaya, Sánchez-Ruiz de Gordoa, Javier, Robles, Maitane, Acha, Blanca, Roldan, Miren, Zelaya, María Victoria, Blanco-Luquin, Idoia, Mendioroz, Maite“…The HOMER1 gene is involved in synaptic plasticity, learning and memory. …”
Publicado 2021
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76Acute Cerebellitis Associated With Anti-homer 3 Antibodies: A Rare Case Report and Literature Reviewpor Miao, Ailiang, Yu, Chuanyong, Sun, Yulei, Wang, Lingling, Ge, Jianqing, Wang, Xiaoshan“…Acute cerebellitis associated with Homer-3 antibodies is very rare. Here we present a 20-year-old woman who suffered from uncontrollable head shaking quickly from side to side and an unsteady gait for 2 days after the cold. …”
Publicado 2022
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80por Szumlinski, Karen K., Beltran, Jacqueline, van Doren, Eliyana, Jimenez Chavez, C. Leonardo, Domingo-Gonzalez, Racquel D., Reyes, Cindy M., Ary, Alexis W., Lang, Andrew, Guo, Weiruo, Worley, Paul F., Huber, Kimberly M.“…In response to neuronal activity, Homer2 is phosphorylated on S117/S216 by calcium-calmodulin kinase IIα (CaMKIIα), which induces a rapid dissociation of mGlu5-Homer2 scaffolds. …”
Publicado 2023
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