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101por Mazengenya, Pedzisai, Bhagwandin, Adhil, Nkomozepi, Pilani, Manger, Paul R., Ihunwo, Amadi O.“…We report here on adult neurogenesis throughout the brains of two breeds of adult domestic pigeons (Columba livia domestica), the racing homer and utility carneau using endogenous immunohistochemical markers proliferating cell nuclear antigen (PCNA) for proliferating cells and doublecortin (DCX) for immature and migrating neurons. …”
Publicado 2017
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102por Wu, Xiuquan, Luo, Peng, Rao, Wei, Dai, Shuhui, Zhang, Lei, Ma, Wenke, Pu, Jingnan, Yu, Yang, Wang, Jiu, Fei, Zhou“…Neuronal oxidative stress is involved in diverse neurological disorders. Homer1a, as an important member of the Homer family and localized at the postsynaptic density, is known to protect cells against oxidative injury. …”
Publicado 2018
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103“…BACKGROUND: Homer scaffolding protein 1 (Homer1) is a postsynaptic scaffold protein that regulates the structure and function of excitatory synaptic as well as its intracellular signal transduction. …”
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104por Lachgar, María, Morín, Matías, Villamar, Manuela, del Castillo, Ignacio, Moreno-Pelayo, Miguel Ángel“…In this study, we report a novel HOMER2 variant (c.832_836delCCTCA) identified in a Spanish family by using a custom NGS targeted gene panel (OTO-NGS-v2). …”
Publicado 2021
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105“…BACKGROUND: This study aimed to explore clinical value and expression of Homer 1, S-adenosyl-l-homocysteine (SAH), homocysteine (Hcy), fibroblast growth factors (FGF) 23 in coronary heart disease (CHD). …”
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106por Papageorgiou, Grigorios, Amoah, Stephen K., Pierotti, Caroline, Otero, Madison, Eckel, Sophie, Coffey, Kacie, Allan, Andrea M., Caldwell, Kevin K., Mellios, Nikolaos“…Using circRNA-specific quantification, we have found that circHomer1, an activity-dependent circRNA derived from Homer protein homolog 1 (Homer1) and enriched in postnatal brain, is significantly down-regulated in the male frontal cortex and hippocampus of mice subjected to modest PAE. …”
Publicado 2023
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107por Fu, Fang, Chen, Chen, Du, Kun, Li, Lu-shan, Li, Ru, Lei, Ting-ying, Deng, Qiong, Wang, Dan, Yu, Qiu-xia, Yang, Xin, Han, Jin, Pan, Min, Zhen, Li, Zhang, Li-na, Li, Jian, Li, Fa-tao, Zhang, Yong-ling, Jing, Xiang-yi, Li, Fu-cheng, Li, Dong-zhi, Liao, Can“…Ndufa4 promoted and miR-145a-5p inhibited the expression of human homer protein homolog 1 and cyclin D2 in neurons. …”
Publicado 2023
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108“…Three novel PAX6-interacting proteins were identified: the post-synaptic density (PSD) protein HOMER3, the dynein subunit DNCL1, and the tripartite motif protein TRIM11. …”
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109por Roselli, Francesco, Hutzler, Peter, Wegerich, Yvonne, Livrea, Paolo, Almeida, Osborne F. X.“…We show that de novo protein synthesis is required for the declustering effects of Aβ on Homer1b (but not Shank1) and that, in contrast to PSD-95, Aβ-induced Homer1b and Shank1 cluster disassembly does not depend on proteasome activity. …”
Publicado 2009
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110“…BACKGROUND: Group I metabotropic glutamate receptor (mGluR1/5) signaling is an important mechanism of pain-related plasticity in the amygdala that plays a key role in the emotional-affective dimension of pain. Homer1a, the short form of the Homer1 family of scaffolding proteins, disrupts the mGluR-signaling complex and negatively regulates nociceptive plasticity at spinal synapses. …”
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111por Rao, Wei, Peng, Cheng, Zhang, Lei, Su, Ning, Wang, Kai, Hui, Hao, Dai, Shu-hui, Yang, Yue-fan, Luo, Peng, Fei, Zhou“…We found that Homer1a protected HT-22 cells from glutamate-induced oxidative stress injury by inhibiting final-phase intracellular calcium overload and mitochondrial oxidative stress. …”
Publicado 2016
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112por Wei, Jialiang, Wu, Xiuquan, Luo, Peng, Yue, Kangyi, Yu, Yang, Pu, Jingnan, Zhang, Lei, Dai, Shuhui, Han, Donghui, Fei, Zhou“…Homer1a is the short form of a scaffold protein that plays a protective role in many forms of stress. …”
Publicado 2019
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113por Vellucci, Licia, Iasevoli, Felice, Filomena Buonaguro, Elisabetta, Latte, Gianmarco, Tomasetti, Carmine, Marmo, Federica, Avagliano, Camilla, Barone, Annarita, de Bartolomeis, Andrea“…In our study we want to evaluate a particular kind of the structural and functional interaction between region of interest (ROI) relevant to schizophrenia pathophysiology: we evaluated the expression of Immediate Early Gene (IEG), Homer1a (H1a), in the different ROI and its functional interaction after Haloperidol (antipsychotic drug) acute administration. …”
Publicado 2020
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114por Liu, Qinghua, He, Lixin, Li, Siqi, Li, Fengyan, Deng, Guangzheng, Huang, Xinjian, Yang, Muwen, Xiao, Yunyun, Chen, Xiangfu, Ouyang, Ying, Chen, Jinxin, Wu, Xuxia, Wang, Xi, Song, Libing, Lin, Chuyong“…BACKGROUND: HOMER family scaffolding proteins (HOMER1-3) play critical roles in the development and progression of human disease by regulating the assembly of signal transduction complexes in response to extrinsic stimuli. …”
Publicado 2021
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115por Rybchyn, Mark S., Brennan-Speranza, Tara Clare, Mor, David, Cheng, Zhiqiang, Chang, Wenhan, Conigrave, Arthur D., Mason, Rebecca S.“…Herein we further investigated the relationship between Homer1 and CaSR and demonstrate a link between the protein levels of CaSR and Homer1 in human osteoblasts in primary culture. …”
Publicado 2021
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116por Yan, Weiwei, Zhu, Hongfei, Yu, Bianbian, Ma, Xin, Liang, Hang, Zhao, Shuyan, Deng, Kebin“…The expression of Homer in tinnitus has not been studied. We hypothesized that expression of Homer in the auditory cortex was altered after tinnitus treatment. …”
Publicado 2021
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117por Fei, Xiaowei, Dou, Ya-nan, Wang, Li, Wu, Xiuquan, Huan, Yu, Wu, Shuang, He, Xin, Lv, Weihao, Wei, Jialiang, Fei, Zhou“…However, the role of Homer1 in ICH-induced inflammation and the effect of Homer1 on the phenotypic conversion of astrocytes remain unknown. …”
Publicado 2022
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118“…However, the ratio of Homer 1a/Homer 1b/c bound to mGluR5 in the PSD was four times lower for AU animals compared to AI rats. …”
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119por Luo, P, Chen, T, Zhao, Y, Zhang, L, Yang, Y, Liu, W, Li, S, Rao, W, Dai, S, Yang, J, Fei, Z“…Intracellular Ca(2+) and PKC were two important factors involved in the mediation of mGluR-ERK signaling by Homer 1a. These results define Homer 1a as a novel endogenous neuroprotective agent against TBI.…”
Publicado 2014
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