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1981por Laitem, Clélia, Zaborowska, Justyna, Isa, Nur F., Kufs, Johann, Dienstbier, Martin, Murphy, Shona“…Using CDK9 inhibitors and global run-on sequencing (GRO-seq), we have mapped CDK9 inhibitor-sensitive checkpoints genome-wide in human (Homo sapiens) cells. Our data indicate that early-elongation checkpoints are a general feature of RNA polymerase (pol) II-transcribed human genes and occur independently of polymerase stalling. …”
Publicado 2015
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1982por Sala, Nohemi, Arsuaga, Juan Luis, Pantoja-Pérez, Ana, Pablos, Adrián, Martínez, Ignacio, Quam, Rolf M., Gómez-Olivencia, Asier, Bermúdez de Castro, José María, Carbonell, Eudald“…Evidence of interpersonal violence has been documented previously in Pleistocene members of the genus Homo, but only very rarely has this been posited as the possible manner of death. …”
Publicado 2015
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1983“…Emergence then becomes quite robust against wiring topology modification—in fact, we considered from a fully connected network to the Homo sapiens connectome—showing the essential role of synaptic flickering on computations. …”
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1984por Cleverley, Robert M., Kean, James, Shintre, Chitra A., Baldock, Clair, Derrick, Jeremy P., Ford, Robert C., Prince, Stephen M.“…X-ray crystal structures have been resolved for two full-length CorA channels, each in a non-conducting state with magnesium ions bound to the protein: These structures reveal a homo-pentameric quaternary structure with approximate 5-fold rotational symmetry about a central pore axis. …”
Publicado 2015
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1985“…The relative amount of monomer was varied to compare three homo- and co-polymer materials: poly(2-hydroxyethyl methacrylate) (pHEMA) and two copolymers of pHEMA and poly(acrylamide) (pAam). …”
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1986“…Blombos Cave is well known as an important site for understanding the evolution of symbolically mediated behaviours among Homo sapiens during the Middle Stone Age, and during the Still Bay in particular. …”
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1987por Kudelka, Matthew R., Antonopoulos, Aristotelis, Wang, Yingchun, Duong, Duc M., Song, Xuezheng, Seyfried, Nicholas T., Dell, Anne, Haslam, Stuart M., Cummings, Richard D., Ju, Tongzhong“…CORA results in ~100–1000-fold increase in sensitivity over conventional O-glycan analyses and identifies a more complex repertoire of O-glycans in more than a dozen cell types from Homo sapiens and Mus musculus. Furthermore, CORA coupled with computational modeling allows predictions on the diversity of the human O-glycome and offers new opportunities to identify novel glycan biomarkers for human diseases.…”
Publicado 2015
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1988“…Here, we report biochemical and structural data that define the N-terminal domain of the Homo sapiens ZNF451 as the catalytic module for SUMO E3 ligase activity. …”
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1989“…When performed on three PPI datasets including Saccharomyces cerevisiae, Homo sapiens, and Helicobacter pylori, we obtained good results of average accuracies of 93.8%, 97.96%, and 89.47%, which are much better than in previous studies. …”
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1990“…DFT calculations revealed substantial changes in the HOMO–LUMO gap that correlated with the extent of conjugation found experimentally. …”
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1991“…The subunit arrangement of the homo-octameric AOX1 differs from that of octameric vanillyl alcohol oxidase and other dimeric or tetrameric alcohol oxidases, due to the insertion of two large protruding loop regions and an additional C-terminal extension in AOX1. …”
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1992“…In this review, we focus on the features and functions of BBs and centrosomes in Homo sapiens.…”
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1993“…As was shown by temperature-dependent UV spectroscopy, 6PP may form weakly stabilizing 6PP–Ag(I)–6PP homo base pairs. Interestingly, 6PP can be used to selectively recognize a complementary pyrimidine nucleobase. …”
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1994“…Frizzled receptors can homo- or hetero-polymerise and associate with several co-receptors to transmit Wnt signalling. …”
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1995por Inoue, Rintaro, Takata, Takumi, Fujii, Norihiko, Ishii, Kentaro, Uchiyama, Susumu, Sato, Nobuhiro, Oba, Yojiro, Wood, Kathleen, Kato, Koichi, Fujii, Noriko, Sugiyama, Masaaki“…Elucidation of a mechanism of subunit dynamics in homo-oligomers of αB-crystallin was tackled through deuteration-assisted small-angle neutron scattering (DA-SANS) and electrospray ionization (ESI) native mass spectrometry (nMS). …”
Publicado 2016
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1996“…By comparing it with the structures of the Homo sapiens EAG-related gene (hERG) channel and the Drosophila EAG-like K(+) (dELK) channel and analyzing the structural features of the hEAG channel, it was identified that a hydrophobic patch on the β-sheet may mediate interaction between the PAS domain and other regions of the channel to regulate its functions.…”
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1997“…We now report the crystal structures of CD2 from Homo sapiens and CD1 and CD2 from Danio rerio HDAC6, and we correlate these structures with activity measurements using a panel of 13 different substrates. …”
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1998“…The polymerization initiation mechanism is based on the difference between the HOMO-LUMO energy levels of the components which permits the formation of a continuous donor-acceptor exchange. …”
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1999“…In fact, we propose that the molecular bases of learning and memory can be based on the reorganization of multiples homo and heteroreceptor complexes into novel assembles in the post-junctional membranes of synapses.…”
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2000por Olszowski, Piotr, Zajac, Lukasz, Godlewski, Szymon, Such, Bartosz, Pawlak, Rémy, Hinaut, Antoine, Jöhr, Res, Glatzel, Thilo, Meyer, Ernst, Szymonski, Marek“…Zn(II)phthalocyanine molecules (ZnPc) were thermally deposited on a rutile TiO(2)(011) surface and on Zn(II)meso-tetraphenylporphyrin (ZnTPP) wetting layers at room temperature and after elevated temperature thermal processing. The molecular homo- and heterostructures were characterized by high-resolution scanning tunneling microscopy (STM) at room temperature and their geometrical arrangement and degree of ordering are compared with the previously studied copper phthalocyanine (CuPc) and ZnTPP heterostructures. …”
Publicado 2017
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