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  1. 2201
    “…We address the problem of detecting m/miRNA targeting relationships in homo sapiens from microarray data by developing statistical models that are motivated by the biological mechanisms used by miRNAs. …”
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    Statistical Use of Argonaute Expression and RISC Assembly in microRNA Target Identification
  2. 2202
    por Subirana, Juan A., Messeguer, Xavier
    Publicado 2010
    “…We present a simple method for the detection and analysis of such sequences in several genomes, including Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster and Homo sapiens. We also study two chromosomes of man and mouse with a length similar to the whole genomes of the other species. …”
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    The most frequent short sequences in non-coding DNA
  3. 2203
    “…Comparisons with orthologous enzymes, in particular from Homo sapiens and Saccharomyces cerevisae, indicate a high degree of sequence and structure conservation in part of the active site. …”
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    Structure of Trypanosoma brucei glutathione synthetase: Domain and loop alterations in the catalytic cycle of a highly conserved enzyme
  4. 2204
    “…Analysis of the ability of SH protein to induce membrane permeability and form homo-oligomers suggests it acts as a viroporin. For the first time, we directly observed functional SH protein using electron microscopy, which revealed SH forms multimeric ring-like objects with a prominent central stained region. …”
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    Direct visualization of the small hydrophobic protein of human respiratory syncytial virus reveals the structural basis for membrane permeability
  5. 2205
    “…Comparative analysis of the homo- and heterotrimer cleavage kinetics revealed that MMP-1 binding promotes stochastic helix unwinding, resolving the controversy between different models of collagenase action.…”
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    Molecular Mechanism of Type I Collagen Homotrimer Resistance to Mammalian Collagenases
  6. 2206
    “…Here the use of the luminescent europium tris-dipicolinate complex [Eu(DPA)(3)](3−) to solve the low-resolution structure of a 444 kDa homo­dodecameric aminopeptidase, called PhTET1-12s from the archaea Pyrococcus horikoshii, is reported. …”
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    Using lanthanoid complexes to phase large macromolecular assemblies
  7. 2207
    por Curnoe, Darren
    Publicado 2011
    “…Moreover, the idea that Australians could trace their ancestry to a non-modern Pleistocene population such as Homo erectus in Southeast Asia have existed for more than 100 years, being explicitly linked to cranial robusticity. …”
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    A 150-Year Conundrum: Cranial Robusticity and Its Bearing on the Origin of Aboriginal Australians
  8. 2208
    “…Some of these clusters match the known ATP binding, DNA binding, and RecA-RecA homo-dimerization sites, but others are novel. Mutation analysis at these sites disrupted either recombination or LexA cleavage. …”
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    Separation of Recombination and SOS Response in Escherichia coli RecA Suggests LexA Interaction Sites
  9. 2209
    “…AKAP5 (MW ~47 kDa) and AKAP12 (MW ~191 kDa) homo-oligomerize, but whether or not such AKAPs can hetero-oligomerize into supermolecular scaffolds of increased complexity is unknown. …”
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    AKAP12 and AKAP5 form higher-order hetero-oligomers
  10. 2210
    “…The VEGFR-2 extracellular domain is responsible for the homo-dimerization process, which has been recently reported as a main step in VEGFR signal transduction cascade. …”
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    New inhibitors of VEGFR-2 targeting the extracellular domain dimerization process
  11. 2211
    “…Application of this method to the Drosophila melanogaster lineage shows that the fraction of adaptive amino acid replacements remained approximately 0.5 for a long time. In the Homo sapiens lineage, however, this fraction drops from approximately 0.5 before the Ponginae–Homininae divergence to approximately 0 after it. …”
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    Detecting Past Positive Selection through Ongoing Negative Selection
  12. 2212
    “…Here we show that the parasite Entamoeba histolytica has evolved a chemokine that mimics the sequence, structure, and function of the human cytokine HsEMAPII (Homo sapiens endothelial monocyte activating polypeptide II). …”
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    Entamoeba lysyl-tRNA Synthetase Contains a Cytokine-Like Domain with Chemokine Activity towards Human Endothelial Cells
  13. 2213
    “…The predicted amino acid sequence shared several conserved features of PAF-AHs of other organisms, and revealed 88, 60, and 46% identity with the homologues of Bombyx mori, Drosophila melanogaster, and Homo sapiens, respectively. Phylogenetic analysis indicated that lepidopteran PAFAHIbαs including ApPAFAHIbα might be a new member of the PAF-AHs family of insects. …”
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    cDNA Cloning and Expression Pattern of Homolog of Alpha Subunit of Platelet-Activating Factor Acetylhydrolase Ib from the Chinese Oak Silkworm, Antheraea pernyi
  14. 2214
    “…We discuss how our structural data of membrane binding Cav fragments may match certain general features of cholesterol-binding domains and could be consistent with the role for CSD in protein recognition and homo-oligomerization.…”
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    Structural Characterization of the Caveolin Scaffolding Domain in Association with Cholesterol-Rich Membranes
  15. 2215
    “…The Current Study aimed to investigate the possible role of Heparanase protein (HPSE-1, [Entrez Pubmed ref|NP_001092010.1|, heparanase isoform 1 preproprotein [Homo sapiens]) in evolution by studying the phylogenetic relationship and divergence of HPSE-1 gene using computational methods. …”
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    A Phylogenetic analysis of Heparanase (HPSE) gene
  16. 2216
    “…These findings demonstrate that both hormonally regulated and phenotypic quality markers can be used as measures of Darwinian fitness among humans living under conditions that resemble the evolutionary environment of Homo sapiens. We also argue that these findings provide support for the Grandmother Hypothesis.…”
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    Voice and Handgrip Strength Predict Reproductive Success in a Group of Indigenous African Females
  17. 2217
    por Zhang, Tong, Mu, Yuguang
    Publicado 2012
    “…Crystal structures of Thermotoga maritima magnesium transporter CorA, reported in 2006, revealed its homo-pentameric constructions. However, the structure of the highly conserved extracellular interhelical loops remains unsolved, due to its high flexibility. …”
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    Initial Binding of Ions to the Interhelical Loops of Divalent Ion Transporter CorA: Replica Exchange Molecular Dynamics Simulation Study
  18. 2218
    “…However, while a human CD95 mutant deleted of the previously described PLAD domain (amino acids 1 to 66) fails to interact with its wild-type counterpart and trigger autonomous cell death, deletion of amino acids 1 to 42 does not prevent homo- or hetero (human/mouse)-oligomerization of CD95, and thus does not alter transmission of the apoptotic signal. …”
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    Precise Mapping of the CD95 Pre-Ligand Assembly Domain
  19. 2219
    “…The lateral transmembrane protein-protein interactions (PPI) have been regarded as “undruggable” despite their importance in many essential biological processes. The homo-trimerization of transmembrane domain 5 (TMD-5) of latent membrane protein 1 (LMP-1) is critical for the constitutive oncogenic activation of the Epstein-Barr virus (EBV). …”
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    Repositioning Antimicrobial Agent Pentamidine as a Disruptor of the Lateral Interactions of Transmembrane Domain 5 of EBV Latent Membrane Protein 1
  20. 2220
    “…This study further reveals that in the absence of ToxS, ToxR interchain disulfide bond formation is facilitated, whereat cysteinyl dependent homo- and oligomerization of ToxR is suppressed if ToxS is coexpressed. …”
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    Disulfide Bond Formation and ToxR Activity in Vibrio cholerae
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