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  1. 2221
    “…Here, we show that HE-4 is secreted in the human seminal fluid as a disulfide-bonded homo-trimer and is a cross-class protease inhibitor inhibits some of the serine, aspartyl and cysteine proteases tested using hemoglobin as a substrate. …”
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    Human Epididymis Protein-4 (HE-4): A Novel Cross-Class Protease Inhibitor
  2. 2222
    “…We sought to ascertain the degree of functional conservation shared by Homo sapiens ARGONAUTE 2 (HsAGO2) and Arabidopsis thaliana ARGONAUTE 1 (AtAGO1), which are the predominant AGO family members involved with miRNA activity in their respective species. …”
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    Expression of human ARGONAUTE 2 inhibits endogenous microRNA activity in Arabidopsis
  3. 2223
    “…Our data are consistent with epidermal growth factor receptors being able to form homo-polymers of at least 10 receptors in the absence of activating ligands.…”
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    Measuring EGFR Separations on Cells with ∼10 nm Resolution via Fluorophore Localization Imaging with Photobleaching
  4. 2224
    “…An in silico analysis of 296 N-terminal, matrix destined MTSs from Homo sapiens, Mus musculus, Saccharomyces cerevisiae, Arabidopsis thaliana, and Oryza sativa was undertaken to investigate relationships between MTSs, and/or, relationships between an individual targeting signal sequence and the protein that it imports. …”
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    Evidence of Evolutionary Constraints That Influences the Sequence Composition and Diversity of Mitochondrial Matrix Targeting Signals
  5. 2225
    “…There was no structural correlation between the nitro-PAHs and their ability to induce lipid peroxidation upon UVA irradiation, or between the HOMO-LUMO gap and the ability to cause lipid peroxidation. …”
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    UVA Photoirradiation of Nitro-Polycyclic Aromatic Hydrocarbons—Induction of Reactive Oxygen Species and Formation of Lipid Peroxides (†)
  6. 2226
    “…Thus, it is important to define differences in the properties of Tm molecules carrying one or two copies of the mutation. We examined the Tm homo- and heterodimer properties: actin affinity, thermal stability, calcium regulation of myosin subfragment 1 binding, and calcium regulation of myofibril force. …”
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    α-Tropomyosin with a D175N or E180G Mutation in Only One Chain Differs from Tropomyosin with Mutations in Both Chains
  7. 2227
    “…These URMs are: (i) positive cooperative binding, (ii) homo-multimerization, (iii) multistep signalling, (iv) molecular titration, (v) zero-order covalent modification cycle and (vi) positive feedback. …”
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    Ultrasensitive response motifs: basic amplifiers in molecular signalling networks
  8. 2228
    “…The PEG3-SCAN domain appears to constitute an assembly block, enabling PEG3 homo- or heterodimerization to control gene expression in a combinatorial fashion.…”
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    Structure of the SCAN Domain of Human Paternally Expressed Gene 3 Protein
  9. 2229
    “…We performed a systematical comparison of mutation regularities within 2–4 bp contexts in Homo sapiens and Drosophila melanogaster and found that the aforementioned contexts are not hypermutable in fruit flies. …”
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    Comparative Analysis of Context-Dependent Mutagenesis in Humans and Fruit Flies
  10. 2230
    “…For this reason, we developed Transimulation – a web service measuring translational activity of genes in three model organisms: Escherichia coli, Saccharomyces cerevisiae and Homo sapiens. The calculations are based on our previous computational model of translation and experimental data sets. …”
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    Transimulation - Protein Biosynthesis Web Service
  11. 2231
    “…These results indicate that Au. africanus, like Homo, walked with an efficient, extended lower limb.…”
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    Trabecular Evidence for a Human-Like Gait in Australopithecus africanus
  12. 2232
    “…We report here the first evidence for homo- and heterotypic adhesion between cells overexpressing the ORs MOR256-17 or M71, supporting the hypothesis that ORs may contribute to olfactory axon sorting by mediating differential adhesion between axons.…”
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    Homotypic and Heterotypic Adhesion Induced by Odorant Receptors and the β2-Adrenergic Receptor
  13. 2233
    “…Glutaric aciduria type 1 (GA1) is an inherited neurometabolic disorder caused by mutations in the GCDH gene encoding glutaryl-CoA dehydrogenase (GCDH), which forms homo- and heteromeric complexes in the mitochondrial matrix. …”
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    Interaction of Glutaric Aciduria Type 1-Related glutaryl-CoA Dehydrogenase with Mitochondrial Matrix Proteins
  14. 2234
    “…The enolase from Streptococcus pyogenes (Str enolase F137L/E363G) is a homo-octamer shaped like a donut. Plasminogen (Pgn) is a monomeric protein composed of seven discrete separated domains organized into a lock washer. …”
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    The Interaction of Streptococcal Enolase with Canine Plasminogen: The Role of Surfaces in Complex Formation
  15. 2235
    “…We have modeled the chemosensory networks and compared the evolutionary constraints of their genes in Mus musculus, Homo sapiens, and Rattus norvegicus. We have observed significant differences regarding the constraints on the orthologous groups and network topologies of chemoreceptors and signal transduction machinery. …”
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    Differential Evolutionary Constraints in the Evolution of Chemoreceptors: A Murine and Human Case Study
  16. 2236
    “…It appears that the halogen bond in DX⋅⋅⋅A(−) arises not only from classical electrostatic attraction but also receives substantial stabilization from HOMO–LUMO interactions between the lone pair of A(−) and the σ* orbital of D–X.…”
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    Halogen Bonding versus Hydrogen Bonding: A Molecular Orbital Perspective
  17. 2237
    “…They are built around a central cartwheel assembly that is organized through homo-oligomerization of the centriolar protein SAS-6, but whether SAS-6 self-assembly can dictate cartwheel and thereby centriole symmetry is unclear. …”
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    Structure of the SAS-6 cartwheel hub from Leishmania major
  18. 2238
    “…The two members of the family reported in humans, namely TLK1 and TLK2, localize to the cell nucleus and are capable of forming homo- or hetero-oligomers by themselves. To characterize the role of TLK2, its C-terminal kinase domain was cloned and overexpressed in Escherichia coli followed by purification to homogeneity. …”
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    Purification, crystallization and preliminary X-ray diffraction analysis of the kinase domain of human tousled-like kinase 2
  19. 2239
    “…The eight lactobacilli were characterized based on the various classical phenotypic tests, physiological tests and biochemical tests including various carbohydrate utilization profiles. All isolates were homo fermentative, catalase, and gelatin negative. …”
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    Molecular characterization of lactobacilli isolated from fermented idli batter
  20. 2240
    “…Oligomerization of all three mammalian ryanodine receptor isoforms, a structural requirement for normal intracellular Ca(2+) release channel function, is displayed by the discrete N-terminal domain which assembles into homo- and hetero-tetramers. This is demonstrated in yeast, mammalian cells and native tissue by complementary yeast two-hybrid, chemical cross-linking and co-immunoprecipitation assays. …”
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    N-terminus oligomerization is conserved in intracellular calcium release channels
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