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2361“…Why and how the human genome has been colonized by pathogen sequences and why and how primates escaped such a colonization appears to be the new scientific challenge in our efforts to understand not only the origin of Homo sapiens but also his autoimmune diseasome.…”
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2362por Rentschler, Martin, Iglesias, Sirma, Schmid, Marie‐Ann, Liu, Cunming, Tschierlei, Stefanie, Frey, Wolfgang, Zhang, Xiaoyi, Karnahl, Michael, Moonshiram, Dooshaye“…A systematic series of four novel homo‐ and heteroleptic Cu(I) photosensitizers based on tetradentate 1,10‐phenanthroline ligands of the type X^N^N^X containing two additional donor moieties in the 2,9‐position (X=SMe or OMe) were designed. …”
Publicado 2020
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2363por Hedison, Tobias M., Shanmugam, Muralidharan, Heyes, Derren J., Edge, Ruth, Scrutton, Nigel S.“…Cryoreduction‐EPR is broadly applicable for the study of electron transfer in other redox enzymes and paves the way to explore transient states in multiple redox‐center containing proteins (homo and hetero metal ions).…”
Publicado 2020
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2364por Sharfalddin, Abeer, Davaasuren, Bambar, Emwas, Abdul-Hamid, Jaremko, Mariusz, Jaremko, Łukasz, Hussien, Mostafa“…The energies of the frontier orbitals, HOMO and LUMO, were used to calculate the chemical quantum parameters. …”
Publicado 2020
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2365por Zarzyka, Iwona, Klásek, Antonin, Hęclik, Karol, Lyčka, Antonin, Bartošík, Radek, Dobrowolski, Lucjan“…The modeling results were consistent with the experimental data. The HOMO electron densities at selected atoms of each substrate has shown that the most reactive atom is sulfur atom. …”
Publicado 2020
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2366“…Trends in the soft frontier orbital and hard electrostatic character are in agreement with calculated proton affinities and energy decomposition analyses of the protonated structures, demonstrating the dominance of the soft (HOMO–LUMO) orbital interactions.…”
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2367“…A molecular docking study was performed to analyze the inhibitory action of newly synthetic quinazolinone derivatives against Homo sapiens AKT1 protein. Molecular docking simulations were found to be in accordance with in vitro studies, and hence supported the biological activity. …”
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2368“…[Image: see text] Metal–organic and covalent–organic frameworks can serve as a bridge between the realms of homo- and heterogeneous catalytic systems. While there are numerous molecular complexes developed for electrocatalysis, homogeneous catalysts are hindered by slow catalyst diffusion, catalyst deactivation, and poor product yield. …”
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2369“…One of the IDRs in Sp1 exhibited homo-oligomer formation. In addition, the same region was used for the interaction with another IDR found in the TAF4 molecule. …”
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2370por Sporny, Michael, Guez-Haddad, Julia, Khazma, Tami, Yaron, Avraham, Dessau, Moshe, Shkolnisky, Yoel, Mim, Carsten, Isupov, Michail N, Zalk, Ran, Hons, Michael, Opatowsky, Yarden“…These indicate that SARM1 homo-octamer avoids premature activation by assuming a packed conformation, with ordered inner and peripheral rings, that prevents dimerization and activation of the catalytic domains. …”
Publicado 2020
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2371“…Apoptotic and pathological conditions, as well as certain viruses, induce cell death by inducing VDAC1 overexpression leading to oligomerization, and the formation of a large channel within the VDAC1 homo-oligomer. This then permits the release of pro-apoptotic proteins from the mitochondria and subsequent apoptosis. …”
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2372por Choi, Bo Hyun, Hwang, Hee Jin, Lee, Ji Eun, Oh, Soon Hwan, Hwang, Jae Sung, Lee, Bun Yeoul, Lee, Pyung Cheon“…A heterologous retinyl palmitate biosynthesis pathway was reconstructed in metabolically engineered Escherichia coli using synthetic expression modules from Pantoea agglomerans, Salinibacter ruber, and Homo sapiens. High production of retinyl palmitate (69.96 ± 2.64 mg/L) was obtained using a fed-batch fermentation process. …”
Publicado 2020
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2373“…Over the past thirty years, it has been established that XET enzymes catalyse homo-transglycosylation reactions with xyloglucan (XG)-derived substrates and hetero-transglycosylation reactions with neutral and charged donor and acceptor substrates other than XG-derived. …”
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2374por Rodrigues Silva, Daniela, de Azevedo Santos, Lucas, Freitas, Matheus P., Guerra, Célia Fonseca, Hamlin, Trevor A.“…For H(3)B−NY(3), the bonding trend is driven by the commonly accepted mechanism of donor−acceptor [HOMO(base)−LUMO(acid)] interaction. Interestingly, for X(3)B−NH(3), the bonding mechanism is determined by the energy required to deform the BX(3) to the pyramidal geometry it adopts in the adduct. …”
Publicado 2020
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2375por Andrikopoulos, Konstantinos, Anastasopoulos, Charalampos, Kallitsis, Joannis K., Andreopoulou, Aikaterini K.“…The polymeric metallocomplexes were found to emit in the orange–red region (550–600 nm) with appropriate HOMO and LUMO levels to be used in conjunction with blue-emitting hosts. …”
Publicado 2020
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2376por Tsuzuki, Yoshikazu, Aoyagi, Ryutaro, Miyaguchi, Kazuya, Ashitani, Keigo, Ohgo, Hideki, Yamaoka, Minoru, Ishizawa, Keisuke, Kayano, Hidekazu, Hisamatsu, Tadakazu, Umeno, Junji, Hosoe, Naoki, Matsumoto, Takayuki, Nakamoto, Hidetomo, Imaeda, Hiroyuki“…SLCO2A1 demonstrated a c.1807C>T homo-mutation. He was also diagnosed with SLCO2A1-associated chronic enteropathy and thus was treated with 5-aminosalicylic acid, which temporarily improved the ileal ulcers, anemia, and hypoalbuminemia.…”
Publicado 2020
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2377“…However, recent studies have established that pituitary cells are organized in tightly wired large-scale networks that communicate with each other in both homo and heterotypic manners, allowing the gland to quickly adapt to changing physiological demands. …”
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2378por D’yakonov, Vladimir A., Tuktarova, Regina A., Dzhemileva, Lilya U., Ishmukhametova, Svetlana R., Dzhemilev, Usein M.“…For the first time, hybrid molecules were synthesized on the basis of lithocholic and (5Z,9Z)-1,14-tetradeca-5,9-dienedicarboxylic acids, obtained in two stages using the homo-cyclomagnesiation reaction of 2-(hepta-5,6-diene-1-yloxy)tetrahydro-2H-pyran at the key stage. …”
Publicado 2021
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2379por Albani, Guglielmo, Calloni, Alberto, Picone, Andrea, Brambilla, Alberto, Capra, Michele, Lodesani, Alessandro, Duò, Lamberto, Finazzi, Marco, Ciccacci, Franco, Bussetti, Gianlorenzo“…In this work, we provide evidence of an ordered disposition of the organic film above the iron surface and we prove that the thin layer of iron oxide decouples the molecules from the substrate, thus preserving the molecular electronic features, especially the HOMO-LUMO gap, even when just a few organic layers are deposited. …”
Publicado 2021
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2380“…Several interunit linkages have been identified and proposed to occur through homo-coupling of the hydroxystilbene glucosides and their cross-coupling with coniferyl alcohol. …”
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