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  1. 3401
    “…Furthermore, there were no significant differences in results of glucose tolerance test among genotypes (homo/hetero/wild). Taken together, these observations indicated that C57BL/6J-Ins1(em1 (cre) Utr) is useful for studies of glucose metabolism and the strategy of bicistronic cre knock-in using the CRISPR/Cas9 system could be useful for production of cre driver mice.…”
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    Generation of CRISPR/Cas9-mediated bicistronic knock-in ins1-cre driver mice
  2. 3402
    “…To date, TiRe contains 397 entries for four organisms: Mus musculus, Rattus norvegicus, Sus domesticus, and Homo sapiens. Analysis of the TiRe dataset of skin wound healing-associated genes showed that skin wound healing genes are (i) over-conserved among vertebrates, but are under-conserved in invertebrates; (ii) enriched in extracellular and immuno-inflammatory genes; and display (iii) high interconnectivity and connectivity to other proteins. …”
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    Tissue repair genes: the TiRe database and its implication for skin wound healing
  3. 3403
    “…The ATPase activity and homo-dimerization of LRD6-6 is essential for its regulation on plant immunity and cell death. …”
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    The Multivesicular Bodies (MVBs)-Localized AAA ATPase LRD6-6 Inhibits Immunity and Cell Death Likely through Regulating MVBs-Mediated Vesicular Trafficking in Rice
  4. 3404
    “…We demonstrated that the TRPM7-like channels are homo-tetramers and their activation mediates calcium influx in oocytes and eggs, which is fundamental to support fertilization and egg activation. …”
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    TRPM7-like channels are functionally expressed in oocytes and modulate post-fertilization embryo development in mouse
  5. 3405
    “…Additionally, we found that these two isoforms can form homo- and/or hetero-dimers with different localisation dynamics. …”
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    Two isoforms of TALDO1 generated by alternative translational initiation show differential nucleocytoplasmic distribution to regulate the global metabolic network
  6. 3406
    “…We have recently reported that the 4-aminoquinoline derivative huprine Y, developed in our group as an anticholinesterasic agent, exhibits a submicromolar potency against Trypanosoma brucei and that its homo- and hetero-dimerization can result in to up to three-fold increased potency and selectivity. …”
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    Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents
  7. 3407
    “…RESULTS: The trend of the calculated HOMO–LUMO gaps nicely compares with the spectral data. …”
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    DFT and TD-DFT calculation of new thienopyrazine-based small molecules for organic solar cells
  8. 3408
    “…Moreover, selection pressure from Homo sapiens on the ZIKV RSCU patterns was found to be dominant compared with that from Aedes aegypti and Aedes albopictus. …”
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    Analysis of Synonymous Codon Usage Bias of Zika Virus and Its Adaption to the Hosts
  9. 3409
    “…Through molecular modeling and yeast-two hybrid studies, we demonstrate that Rib and Lola homo- and heterodimerize via their BTB domains. In addition, analysis of the colocalization of Rib and Lola with marks of transcriptional activation and repression on polytene chromosomes reveals that Rib and Lola colocalize with both repressive and activating marks and with each other. …”
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    Regulation of Gonad Morphogenesis in Drosophila melanogaster by BTB Family Transcription Factors
  10. 3410
    “…From sequence analysis of the genome of Homo sapiens, followed by sampling humans from different ethnic backgrounds, and chimpanzees, we have identified 27 NUMTs that are specific to humans and must have colonized human chromosomes in the last 4–6 million years. …”
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    Continued Colonization of the Human Genome by Mitochondrial DNA
  11. 3411
    “…Here, we present the crystal structure of PECAM-1 IgL1-2 trans-homo dimer. Both IgL 1 and 2 adopt the classical Ig domain conformation comprised of two layers of β-sheets possessing antiparallel β-strands with each being anchored by a pair of cysteines forming a disulfide bond. …”
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    Structural Basis for Human PECAM-1-Mediated Trans-homophilic Cell Adhesion
  12. 3412
    “…The mechanisms by which SCAN homo- and heterodimers assemble and how they alter the transcriptional activity of zinc-finger transcription factors in cancer and other diseases remain to be investigated. …”
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    The Mutational Landscape of the Oncogenic MZF1 SCAN Domain in Cancer
  13. 3413
    “…From the scientific literature, we totally collected over 580 experimentally identified histone regulators from eight model organisms, including Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Caenorhabditis elegans, Arabidopsis thaliana, Schizosaccharomyces pombe and Saccharomyces cerevisiae. …”
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    WERAM: a database of writers, erasers and readers of histone acetylation and methylation in eukaryotes
  14. 3414
    “…Two of the most promising O(2)-transporters (Homo sapiens AQP1 and Nicotiana tabacum PIP1;3) were confirmed to facilitate O(2) transport in the spectrophotometric assay using yeast protoplasts. …”
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    Significance of oxygen transport through aquaporins
  15. 3415
    por Kawabata, Takeshi
    Publicado 2016
    “…For the services “Modeling a Homo Protein Multimer” and “Modeling a Hetero Protein Multimer”, a user can input one or two proteins as the queries, while for the service “Protein-Compound Complex”, a user can input one chemical compound and one protein. …”
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    HOMCOS: an updated server to search and model complex 3D structures
  16. 3416
    “…This could contribute to both homo- and trans-phobia that will in turn strengthen the belief that transsexual women are un-African.…”
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    Injustice to transsexual women in a hetero-normative healthcare system
  17. 3417
    “…Homo sapiens harbor two distinct, medically significant species of simplexviruses, herpes simplex virus (HSV)-1 and HSV-2, with estimated divergence 6–8 million years ago (MYA). …”
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    Worldwide circulation of HSV-2 × HSV-1 recombinant strains
  18. 3418
    “…Homo sapiens longevity assurance homolog 2 of yeast LAG1 (LASS2) is a novel suppressor of human cancer metastasis, and downregulation of LASS2 has been associated with a poor prognosis in patients with bladder cancer (BC). …”
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    LASS2 inhibits growth and invasion of bladder cancer by regulating ATPase activity
  19. 3419
    por Mei, Suyu, Zhu, Hao
    Publicado 2015
    “…In this work, we propose a novel negative data sampling method based on one-class SVM (support vector machine, SVM) to predict proteome-wide protein interactions between HTLV retrovirus and Homo sapiens, wherein one-class SVM is used to choose reliable and representative negative data, and two-class SVM is used to yield proteome-wide outcomes as predictive feedback for rational model selection. …”
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    A novel one-class SVM based negative data sampling method for reconstructing proteome-wide HTLV-human protein interaction networks
  20. 3420
    “…We validated our approach using three independent data sets with known lineage and developmental time information from both Homo sapiens and Mus musculus. SLICE successfully measured the differentiation states of single cells and reconstructed cell differentiation trajectories that have been previously experimentally validated. …”
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    SLICE: determining cell differentiation and lineage based on single cell entropy
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