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3761“…The results show that: 1) no single patterning mechanism can create a 2-dimensional mosaic pattern of the regularity seen in the chick inner ear; 2) cell death was essential to generate the most regular mosaics, even through extensive cell death has not been reported for the developing basilar papilla; 3) a model that includes an iterative loop of lateral inhibition, programmed cell death and cell rearrangements driven by differential adhesion created mosaics of primary and secondary cells that are more regular than the basilar papilla; 4) this same model was much more robust to changes in homo- and heterotypic cell-cell adhesive differences than models that considered either fewer patterning mechanisms or single rather than iterative use of each mechanism. …”
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3762“…RESULTS: We identified and annotated in the MitoComp2 dataset the orthologs of 68 nuclear genes controlling oxidative phosphorylation in 11 Drosophilidae species and in five non-Drosophilidae insects, and compared them with each other and with their counterparts in three vertebrates (Fugu rubripes, Danio rerio and Homo sapiens) and in the cnidarian Nematostella vectensis, taking into account conservation of gene structure and regulatory motifs, and preservation of gene paralogs in the genome. …”
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3763“…We also examined possible enrichment of co-occurring domains and homo-domains among domain interactions mediating the interaction of proteins in the network. …”
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3764por Foley, Janet, Fort, Raymond C., McDougal, Katherine, Bruce, Mitchell R. M., Bruce, Alice E.“…The unusual yellow color of Au(2)(dppm)(SR)(2) (R = 4-tolyl; dppm = diphenylphosphinomethane) is attributed to a red-shift in the S→Au charge transfer caused by destabilization of the sulfur highest occupied molecular orbital (HOMO). Variable temperature experiments show two broad bands at -80°C in the (31)P{(1)H} NMR spectrum of Au(2)(dppm)(SR)(2) and the activation energy for interconversion is 10 kcal/mol. …”
Publicado 1994
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3765por Cardone, Maria Francesca, Jiang, Zhaoshi, D'Addabbo, Pietro, Archidiacono, Nicoletta, Rocchi, Mariano, Eichler, Evan E, Ventura, Mario“…Human, chimpanzee and gorilla homologous chromosomes differ by a paracentric inversion that occurred specifically in the Homo sapiens/Pan troglodytes/Gorilla gorilla ancestor. …”
Publicado 2008
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3766por Jöchl, Christoph, Rederstorff, Mathieu, Hertel, Jana, Stadler, Peter F., Hofacker, Ivo L., Schrettl, Markus, Haas, Hubertus, Hüttenhofer, Alexander“…Small non-protein-coding RNAs (ncRNAs) have systematically been studied in various model organisms from Escherichia coli to Homo sapiens. Here, we analyse the small ncRNA transcriptome from the pathogenic filamentous fungus Aspergillus fumigatus. …”
Publicado 2008
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3767por Heyne, Kristina, Schmitt, Katrin, Mueller, Daniel, Armbruester, Vivienne, Mestres, Pedro, Roemer, Klaus“…Not necessarily so with p53. This homo-tetrameric transcription factor can become contaminated with mutant p53 through hetero-tetramerization. …”
Publicado 2008
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3768por Tranchevent, Léon-Charles, Barriot, Roland, Yu, Shi, Van Vooren, Steven, Van Loo, Peter, Coessens, Bert, De Moor, Bart, Aerts, Stein, Moreau, Yves“…Second, we support multiple species: in addition to Homo sapiens, we now provide gene prioritization for three major model organisms: Mus musculus, Rattus norvegicus and Caenorhabditis elegans. …”
Publicado 2008
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3769“…To inquire whether other MRFs shared the DNA binding preferences of MyoD, the DNA affinities of hetero- and homo-dimeric MyoD, MRF4 and Myogenin were compared. …”
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3770por Fritz, Joëlle V, Didier, Pascal, Clamme, Jean-Pierre, Schaub, Emmanuel, Muriaux, Delphine, Cabanne, Charlotte, Morellet, Nelly, Bouaziz, Serge, Darlix, Jean-Luc, Mély, Yves, de Rocquigny, Hugues“…RESULTS: Results show that Vpr forms homo-oligomers at or close to the nuclear envelope. …”
Publicado 2008
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3771por Feng, Shuang, Okenka, Genevieve M., Bai, Chang-Xi, Streets, Andrew J., Newby, Linda J., DeChant, Brett T., Tsiokas, Leonidas, Obara, Tomoko, Ong, Albert C. M.“…PC2 has been found to form oligomers in native tissues suggesting that it may form functional homo- or heterotetramers with other subunits, similar to other TRP channels. …”
Publicado 2008
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3772“…In particular, the hetero-and homo-dimerisation of proteins is a commonly encountered motif in signalling pathways. …”
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3773por Cox, Murray P., Morales, David A., Woerner, August E., Sozanski, Jesse, Wall, Jeffrey D., Hammer, Michael F.“…BACKGROUND: A major unanswered question in the evolution of Homo sapiens is when anatomically modern human populations began to expand: was demographic growth associated with the invention of particular technologies or behavioral innovations by hunter-gatherers in the Late Pleistocene, or with the acquisition of farming in the Neolithic? …”
Publicado 2009
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3774“…We first tested our method on Homo sapiens genome; using a very few known human miRNAs as samples, our method achieved a prediction accuracy greater than 95%. …”
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3775“…Although we speculate that selection for homogenization could have been utilized in order to maintain crucial homo- or hetero- binding domains, it remains unclear why gene conversion has persisted for such extended periods of time. …”
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3776por Hocknull, Scott A., Piper, Philip J., van den Bergh, Gert D., Due, Rokus Awe, Morwood, Michael J., Kurniawan, Iwan“…Varanus komodoensis body size has remained stable over the last 900,000 years (ka) on Flores, a time marked by major faunal turnovers, extinction of the island's megafauna, the arrival of early hominids by 880 ka, co-existence with Homo floresiensis, and the arrival of modern humans by 10 ka. …”
Publicado 2009
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3777“…The complex miR-17 family was mainly distributed in vertebrates, but miR-124 was shared by more animal species from Caenorhabditis to Homo and had a wide distribution spectrum. Some haplotypes of the two miRNA families appeared discontinuous distributions across animals. …”
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3778por te Velthuis, Aartjan J. W., Arnold, Jamie J., Cameron, Craig E., van den Worm, Sjoerd H. E., Snijder, Eric J.“…The SARS-CoV nsp12 is primer dependent on both homo- and heteropolymeric templates, supporting the likeliness of a close enzymatic collaboration with the intriguing RNA primase activity that was recently proposed for coronavirus nsp8.…”
Publicado 2010
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3779por Lumsden, Thomas, Bentley, Amber A., Beutler, William, Ghosh, Arnab, Galkin, Oleksandr, Komar, Anton A.“…Alignment of rpS5/rpS7 from metazoans (Homo sapiens), fungi (Saccharomyces cerevisiae) and bacteria (Escherichia coli) shows that the proteins contain a conserved central/C-terminal core region and possess variable N-terminal regions. …”
Publicado 2010
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3780por Suzuki, Tadaki, Orba, Yasuko, Okada, Yuki, Sunden, Yuji, Kimura, Takashi, Tanaka, Shinya, Nagashima, Kazuo, Hall, William W., Sawa, Hirofumi“…Our findings demonstrate that: (i) A deletion mutant of agnoprotein is defective in virion release and viral propagation; (ii) Agnoprotein localizes to the ER early in infection, but is also found at the plasma membrane late in infection; (iii) Agnoprotein is an integral membrane protein and forms homo-oligomers; (iv) Agnoprotein enhances permeability of cells to the translation inhibitor hygromycin B; (v) Agnoprotein induces the influx of extracellular Ca(2+); (vi) The basic residues at amino acid positions 8 and 9 of agnoprotein key are determinants of the viroporin activity. …”
Publicado 2010
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