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4541por Warren, Sean C., Margineanu, Anca, Alibhai, Dominic, Kelly, Douglas J., Talbot, Clifford, Alexandrov, Yuriy, Munro, Ian, Katan, Matilda, Dunsby, Chris, French, Paul M. W.“…We demonstrate that this global approach allows us to readily fit time-resolved fluorescence data to complex models including a four-exponential model of a FRET system, for which the FRET efficiencies of the two species of a bi-exponential donor are linked, and polarisation-resolved lifetime data, where a fluorescence intensity and bi-exponential anisotropy decay model is applied to the analysis of live cell homo-FRET data. A software package implementing this algorithm, FLIMfit, is available under an open source licence through the Open Microscopy Environment.…”
Publicado 2013
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4542por Contreras-Galindo, Rafael, Kaplan, Mark H., He, Shirley, Contreras-Galindo, Angie C., Gonzalez-Hernandez, Marta J., Kappes, Ferdinand, Dube, Derek, Chan, Susana M., Robinson, Dan, Meng, Fan, Dai, Manhong, Gitlin, Scott D., Chinnaiyan, Arul M., Omenn, Gilbert S., Markovitz, David M.“…Our studies suggest that the progenitor K111 integrated before the Homo-Pan divergence and expanded in copy number during the evolution of hominins, perhaps by recombination. …”
Publicado 2013
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4543por Tsegai, Zewdi J., Kivell, Tracy L., Gross, Thomas, Nguyen, N. Huynh, Pahr, Dieter H., Smaers, Jeroen B., Skinner, Matthew M.“…Building upon traditional volume of interest-based analyses, we apply a whole-epiphysis analytical approach using high-resolution microtomographic scans of the hominoid third metacarpal to investigate whether trabecular structure reflects differences in hand posture and loading in knuckle-walking (Gorilla, Pan), suspensory (Pongo, Hylobates and Symphalangus) and manipulative (Homo) taxa. Additionally, a comparative phylogenetic method was used to analyse rates of evolutionary changes in trabecular parameters. …”
Publicado 2013
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4544por Assumpção, Juliana Godoy, Paula, Francisco Danilo Ferreira, Xavier, Sandra Guerra, Murao, Mitiko, de Aguirre, Joaquim Caetano, Dutra, Álvaro Pimenta, Lima, Eduardo Ribeiro, de Oliveira, Benigna Maria, Viana, Marcos Borato“…Clonal rearrangements were detected by polymerase chain reaction followed by homo/heteroduplex clonality analysis in DNA samples from diagnostic bone marrow. …”
Publicado 2013
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4545por van Haagen, Herman H. H. B. M., 't Hoen, Peter A. C., Mons, Barend, Schultes, Erik A.“…Our text-mining system recognizes over 640,000 biomedical concepts: some are specific (i.e., names of genes or proteins) others generic (e.g., ‘Homo sapiens’). Generic concepts may play important roles in automated information retrieval, extraction, and inference but may also result in concept overload and confound retrieval and reasoning with low-relevance or even spurious links. …”
Publicado 2013
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4546por Moncel, Marie-Hélène, Despriée, Jackie, Voinchet, Pierre, Tissoux, Hélène, Moreno, Davinia, Bahain, Jean-Jacques, Courcimault, Gilles, Falguères, Christophe“…If the first phase of hominin occupation (as early as 1.4 Ma) seems mainly restricted to the southern part of the continent, the second phase, characterized by specific lithic tools (handaxes), is linked to Acheulean settlements and to the emergence of Homo heidelbergensis, the ancestor of Neanderthals. …”
Publicado 2013
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4547“…In spite of the lack of fully adequate template structures, the presence of an untypical CARD domain and unusually high number of LRRs in NLRC5, we were able to construct a homology model for both the monomeric and homo-heptameric full-length human NLRC5 protein.…”
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4548“…We present the first predicted interactome for the forest tree Populus trichocarpa in addition to the predicted interactomes for Saccharomyces cerevisiae, Homo sapiens, Mus musculus, and Arabidopsis thaliana. …”
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4549“…Through the automatic analysis of a large set of public available databases, we found statistical evidence that this inter-pathway regulatory motif is very common in several classes of KEGG Homo Sapiens pathways and concurs in creating a complex regulatory network involving several pathways connected by this specific motif. …”
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4550“…Single nucleotide polymorphism (SNP) discovery resulted in 3,537,794 SNP calls with 29,184 SNPs identified in coding regions, where 106 were nonsense and 259 were categorized as having a high-impact effect. The homo/hetero zygosity (1,415,123∶2,122,671 or 1∶1.5) and transition/transversion ratios (2,383,204∶1,154,590 or 2.06∶1) were within expected limits. …”
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4551“…Variation in the number of chromosomes was revealed in 61 samples of Cimex lectularius Linnaeus, 1758 from the Czech Republic and other European countries, hosted on Myotis Kaup, 1829 (4) and Homo sapiens Linnaeus, 1758 (57). The karyotype of all the specimens of Cimex lectularius analysed contained 26 autosomes and a varying number of the sex chromosomes. …”
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4552“…These distinct phenotypes were equally evident in both homo- and hetero-zygous cultures (Abl/Abl vs. Abl/+) of different alleles (Abl(1) and Abl(4)) indicating dominant mutational effects. …”
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4553por Cattoni, Diego I., Thakur, Shreyasi, Godefroy, Cedric, Le Gall, Antoine, Lai-Kee-Him, Josephine, Milhiet, Pierre-Emmanuel, Bron, Patrick, Nöllmann, Marcelo“…First, we find that SpoIIIE binds DNA as a homo-hexamer with neither ATP binding nor hydrolysis affecting the binding mechanism or affinity. …”
Publicado 2014
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4554por Vieira, Leila do Nascimento, Faoro, Helisson, Rogalski, Marcelo, Fraga, Hugo Pacheco de Freitas, Cardoso, Rodrigo Luis Alves, de Souza, Emanuel Maltempi, de Oliveira Pedrosa, Fábio, Nodari, Rubens Onofre, Guerra, Miguel Pedro“…The P. lambertii cp genome presents a total of 28 tandem repeats and 156 SSRs, with homo- and dipolymers being the most common and tri-, tetra-, penta-, and hexapolymers occurring with less frequency. …”
Publicado 2014
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4555“…I(h) is carried by channels consisting of homo- or heteromeric assemblies of four protein subunits from the Hcn gene family. …”
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4556“…[Image: see text] The three-dimensional structures of the dihydrofolate reductase enzymes from Escherichia coli (ecDHFR or ecE) and Homo sapiens (hDHFR or hE) are very similar, despite a rather low level of sequence identity. …”
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4557por Petchampai, Natthida, Sunyakumthorn, Piyanate, Guillotte, Mark L., Verhoeve, Victoria I., Banajee, Kaikhushroo H., Kearney, Michael T., Macaluso, Kevin R.“…Amino acid sequence analysis showed variation (ranging from 25–88%) in percent identity compared to the corresponding subunits of the complex from Drosophila melanogaster, Mus musculus, Homo sapiens, and Saccharomyces cerevisiae. Potential ATP binding sites were identified in D. variabilis (Dv) Arp2 and Arp3 subunits as well as five putative WD (Trp-Asp) motifs which were observed in DvARPC1. …”
Publicado 2014
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4558por Sayeed, Syed K, Shah, Varun, Chaubey, Shweta, Singh, Meetali, Alampalli, Shuba V, Tatu, Utpal S“…RESULTS: PfHSBP is a conserved protein with a high helical content and has a propensity to form homo-oligomers. PfHSBP was cloned, expressed and purified. …”
Publicado 2014
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4559por Dai, Enyu, Yu, Xuexin, Zhang, Yan, Meng, Fanlin, Wang, Shuyuan, Liu, Xinyi, Liu, Dianming, Wang, Jing, Li, Xia, Jiang, Wei“…In this study, we established the EpimiR database, which collects 1974 regulations between 19 kinds of epigenetic modifications (such as DNA methylation, histone acetylation, H3K4me3, H3S10p) and 617 miRNAs across seven species (including Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus, Epstein–Barr virus, Canis familiaris and Arabidopsis thaliana) from >300 references in the literature. …”
Publicado 2014
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4560The Dnmt2 RNA methyltransferase homolog of Geobacter sulfurreducens specifically methylates tRNA-Glupor Shanmugam, Raghuvaran, Aklujkar, Muktak, Schäfer, Matthias, Reinhardt, Richard, Nickel, Olaf, Reuter, Gunter, Lovley, Derek R., Ehrenhofer-Murray, Ann, Nellen, Wolfgang, Ankri, Serge, Helm, Mark, Jurkowski, Tomasz P., Jeltsch, Albert“…The activities of Dnmt2 enzymes from Homo sapiens, Drosophila melanogaster, Schizosaccharomyces pombe and Dictyostelium discoideum for methylation of the Geobacter tRNA-Asp and tRNA-Glu were determined showing that all these Dnmt2s preferentially methylate tRNA-Asp. …”
Publicado 2014
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