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  1. 4741
    “…The synthetic pathway included the transformation of betulin via Jones' oxidation into betulonic acid, reductive amination of the latter and coupling obtained by 3β-amino-3-deoxybetulinic acid with the 7- or 13-azaprostanoic acids and their homo analogues. The hybrids 1-9 were investigated in vivo on histamine-, formalin- and concanavalin A-induced mouse paw edema models and two models of pain - the acetic acid-induced abdominal writhing and the hot-plate test. …”
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    Betulinic Acid-Azaprostanoid Hybrids: Synthesis and Pharmacological Evaluation as Anti-inflammatory Agents
  2. 4742
    “…While dimerization is obligatory for DNA binding, SEP3 and SEP3–AG also form tetrameric complexes. How homo and hetero-dimerization and tetramerization of MADS TFs affect genome-wide DNA-binding and gene regulation is not known. …”
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    Genome-wide binding of SEPALLATA3 and AGAMOUS complexes determined by sequential DNA-affinity purification sequencing
  3. 4743
    “…To elucidate the functions of these two miRNAs, Homo sapiens (hsa)-miR-218-5p and hsa-miR-1262 and their regulatory network, target gene prediction was first performed using online TargetScan and Diana-micro T software. …”
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    Investigating aberrantly expressed microRNAs in peripheral blood mononuclear cells from patients with treatment-resistant schizophrenia using miRNA sequencing and integrated bioinformatics
  4. 4744
    “…Further bioinformatics prediction showed that both Gas-miR01 and Gas-miR02 could target Homo sapiens A20 gene, furthermore, the dual-luciferase reporter gene assay and Western Blotting verified the interaction of Gas-miR01 or Gas-miR02 with A20. …”
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    Identification and Investigation of miRNAs From Gastrodia elata Blume and Their Potential Function
  5. 4745
    “…This modeling was established by the correlation between the corrosion inhibition efficiency (IE %) and a number of the electronic and structural properties of these inhibitors such as: the E(HOMO) (highest occupied molecular orbital energy), the E(LUMO) (lowest unoccupied molecular orbital energy), the energy gap (E(L-H)), the dipole moment (μ), the hardness (η), the softness (σ), the absolute electronegativity (χ), the ionization potential (IP), the electron affinity (EA), the fraction of electrons transferred (ΔN), the electrophilicity index ω the molecular volume (V(m)), the logarithm of the partition coefficient (Log P), and the molecular mass (M), in addition to the inhibitor concentration (C(i)). …”
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    Development and validation of QSPR models for corrosion inhibition of carbon steel by some pyridazine derivatives in acidic medium
  6. 4746
    “…Interaction of these factors offers a resource-oriented hypothesis for the evolutionary success of MSA adaptations, which likely contributed to the ecological flexibility typical of Homo sapiens foragers.…”
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    Increased ecological resource variability during a critical transition in hominin evolution
  7. 4747
    “…Analysis across all annotated coding exon junctions in Homo sapiens reveals the information content of coding exons to be greater than the surrounding intron regions, a consequence of increased suppression of the CG dinucleotide in intronic space. …”
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    A model of k-mer surprisal to quantify local sequence information content surrounding splice regions
  8. 4748
    “…BACKGROUND: A new virus “Pokémon GO” is infecting Homo sapiens at an exponential rate. The symptoms include swaying your cell phone in air and focusing in blankness, straying into the unknown in search “Pikachu”. …”
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    Correlates of excessive Pokemon Go playing among medical students
  9. 4749
    por Beseris, E A, Naleway, S E, Carrier, D R
    Publicado 2020
    “…Because facial hair is one of the most sexually dimorphic features of humans (Homo sapiens) and is often perceived as an indicator of masculinity and social dominance, human facial hair has been suggested to play a role in male contest competition. …”
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    Impact Protection Potential of Mammalian Hair: Testing the Pugilism Hypothesis for the Evolution of Human Facial Hair
  10. 4750
    “…Finally, MiSSP7 strengthens the binding of PtJAZ6 to PtMYC2.1 and antagonizes PtJAZ6 homo-/heterodimerization. We conclude that a symbiotic effector secreted by a mutualistic fungus may promote the symbiotic interaction through altered dynamics of a JA-signaling-associated protein–protein interaction network, maintaining the repression of PtMYC2.1-regulated genes.…”
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    The mutualism effector MiSSP7 of Laccaria bicolor alters the interactions between the poplar JAZ6 protein and its associated proteins
  11. 4751
    “…Prepared proteins were evaluated using SAVES and the studies of molecular dynamics of the hexokinase, and the GROMACS were performed for protein–ligand complex. The low HOMO-LUMO energy gaps of the compound verified the greater stability of the molecule. …”
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    Identification of potential drug target in malarial disease using molecular docking analysis
  12. 4752
    “…Altogether, 21 MPCs could be detected including multi homo-oligomeric and multi hetero-oligomeric complexes distributed in both inner and outer membranes. …”
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    Membrane Proteocomplexome of Campylobacter jejuni Using 2-D Blue Native/SDS-PAGE Combined to Bioinformatics Analysis
  13. 4753
    “…One structural component is any antibody or Fc fusion and the second is a designed Fc-binding homo-oligomer that drives nanocage assembly. Structures of 8 antibody nanocages determined by electron microscopy spanning dihedral, tetrahedral, octahedral, and icosahedral architectures with 2, 6, 12, and 30 antibodies per nanocage match the corresponding computational models. …”
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    Designed proteins assemble antibodies into modular nanocages
  14. 4754
    “…We demonstrate the potential insight that can be obtained from the use of MC-ANOVA and Eigen-ANOVA by applying these two methods to the study of multi-locus linkage disequilibrium in chicken (Gallus gallus) genomes and to the assessment of inter-dependencies between gene expression, methylation, and copy-number-variants in data from breast cancer tumors from humans (Homo sapiens). Our analyses reveal that in chicken breeding populations ~50,000 evenly-spaced SNPs are enough to fully capture the span of whole-genome-sequencing genomes. …”
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    ANOVA-HD: Analysis of variance when both input and output layers are high-dimensional
  15. 4755
    “…Externally applied ZnCl(2) drastically reduces proton currents reportedly recorded in Homo sapiens, Rattus norvegicus, Mus musculus, Oryctolagus cuniculus, Rana esculenta, Helix aspersa, Ciona intestinalis, Coccolithus pelagicus, Emiliania huxleyi, Danio rerio, Helisoma trivolvis, and Lingulodinium polyedrum, but with considerable species variability. …”
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    Zinc modulation of proton currents in a new voltage‐gated proton channel suggests a mechanism of inhibition
  16. 4756
    “…Our investigation considered a comprehensive number of publicly available genomes for seven coronaviruses (SARS-CoV-2, SARS-CoV, and MERS infecting Homo sapiens, Bovine CoV infecting Bos taurus, MHV infecting Mus musculus, HEV infecting Sus scrofa, and CRCoV infecting Canis lupus familiaris). …”
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    Coronavirus genomes carry the signatures of their habitats
  17. 4757
    “…DBAASP is updated continuously, and at present, version 3.0 (DBAASP v3) contains >15 700 entries (8000 more than the previous version), including >14 500 monomers and nearly 400 homo- and hetero-multimers. Of the monomeric antimicrobial peptides (AMPs), >12 000 are synthetic, about 2700 are ribosomally synthesized, and about 170 are non-ribosomally synthesized. …”
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    DBAASP v3: database of antimicrobial/cytotoxic activity and structure of peptides as a resource for development of new therapeutics
  18. 4758
    “…We identify interface properties, which show statistically significant difference between native and non-native interfaces belonging to homo and hetero, protein–protein complexes. Utilizing these properties, a support vector machine (SVM) based classification scheme has been implemented to differentiate native and non-native like complexes generated using docking decoys. …”
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    Classification and prediction of protein–protein interaction interface using machine learning algorithm
  19. 4759
    “…Density functional theory (DFT) may help find the relevancy of quantum chemical descriptors to explain the potential antiviral activity, Some quantum descriptors such as ΔE; the energy gap, η; global hardness, S; global softness, I: ionization potential, A: electron affinity, χ: absolute electronegativity, ω; ΔE (Back-donation); the back donation were calculated based on E(HOMO); energy of the highest occupied molecular orbital, and E(LUMO); energy of the lowest unoccupied molecular orbital. …”
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    Comparative study on quantum descriptors, molecular docking and dynamic simulation of antiviral drugs with Covid-19
  20. 4760
    “…The most significant KEGG pathway was ‘leukocyte transendothelial migration’. The circRNAs Homo sapiens (hsa)_circ_0135895, hsa_circ_0000682 and hsa_circ_0000690, which were also associated with the above-mentioned pathway, were indicated to be able to regulate protein tyrosine kinase 2, protein kinase Cβ and integrin subunit αL, respectively. …”
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    Circular RNA expression profile in human primary multiple intracranial aneurysm
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