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  1. 4801
    “…It appears that during the brain organ evolution, Sirt6 has gained more relevance as the brain becomes bigger and more complex, observing the most detrimental effect in the brains of Homo sapiens. In this perspective, we part from the evolution of the brain in metazoans, the biological similarities between brain development and aging, and the relevant functions of Sirt6 in these similar phenomena to conclude with the evidence suggesting a more relevant role of Sirt6 gained in the brain evolution.…”
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    SIRT6 Through the Brain Evolution, Development, and Aging
  2. 4802
    “…Several studies have indicated that Homo sapiens (hsa)-microRNA (miR)-429 exerts a tumor-suppressive effect on a variety of malignant tumors. …”
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    hsa-miR-429 targets CBX8 to promote cell apoptosis in diffuse large B-cell lymphoma
  3. 4803
    “…We found that CAHS1 proteins homo-oligomerized via the C-terminal α-helical region and formed a hydrogel as their concentration increased. …”
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    Desiccation-induced fibrous condensation of CAHS protein from an anhydrobiotic tardigrade
  4. 4804
    “…Kerodon rupestris, rocky cavy (13/39), Homo sapiens, human (8/39), and Bos taurus, ox (6/39) were the most frequently detected blood meals sources. …”
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    The connection between Trypanosoma cruzi transmission cycles by Triatoma brasiliensis brasiliensis: A threat to human health in an area susceptible to desertification in the Seridó, Rio Grande do Norte, Brazil
  5. 4805
    “…Approximately half of the homo‐ and heterozygous Cx36KO, but none WT, mice succumbed by respiratory arrest when submitted to hypoxia‐hypercapnia, the principal exogenous stressor causing sudden infant death syndrome (SIDS). …”
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    Respiratory disturbances and high risk of sudden death in the neonatal connexin‐36 knockout mouse
  6. 4806
    “…As a result, therapeutic interventions to change the composition of the vaginal microbiomes are under development. However, Homo sapiens is the only mammalian species which has high frequencies of Lactobacillus-dominated vaginal microbiomes. …”
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    The Vaginal Microbiome of Nonhuman Primates Can Be Only Transiently Altered to Become Lactobacillus Dominant without Reducing Inflammation
  7. 4807
    “…We previously reported that the amphiphilic polypeptide SL12 with a polysarcosine (PSar) hydrophilic chain and hydrophobic α-helix (l-Leu-Aib)(6) involving the LxxxLxxxL sequence, which induces homo-dimerization due to the concave–convex interaction, formed a nanotube with a uniform 80 nm diameter. …”
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    Tubular Assembly Formation Induced by Leucine Alignment along the Hydrophobic Helix of Amphiphilic Polypeptides
  8. 4808
    “…Residues from domain 2 that comprise elements of both the active site and the homo-dimerization interface fit less well across all structures. …”
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    Concordance of X-ray and AlphaFold2 Models of SARS-CoV-2 Main Protease with Residual Dipolar Couplings Measured in Solution
  9. 4809
    “…Live-cell fluorescence resonance energy transfer (FRET) analysis showed that Met unlocked the binding of Mcl-1 to Bak, and enhanced the binding of Bim to Bak and subsequent Bak homo-oligomerization. Western blotting analysis showed that Met enhanced AMPK phosphorylation and Bim expression, and compound C, an inhibitor of AMPK, inhibited Met-induced Bim upregulation. …”
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    Bak instead of Bax plays a key role in metformin-induced apoptosis s in HCT116 cells
  10. 4810
    “…To explore factors that influence hetero‐transglucosylation, we studied Equisetum fluviatile hetero‐trans‐β‐glucanase (EfHTG), which exhibits both CXE and MXE activity, exceeding its xyloglucan:xyloglucan homo‐transglucosylation (XET) activity. Enzyme assays employed radiolabelled and fluorescently labelled oligomeric acceptor substrates, and were conducted in vitro and in cell walls (in situ). …”
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    Defining natural factors that stimulate and inhibit cellulose:xyloglucan hetero‐transglucosylation
  11. 4811
    “…Opioid receptors (ORs) have been observed as homo- and heterodimers, but it is unclear if the dimers are stable under physiological conditions, and whether monomers or dimers comprise the predominant fraction in a cell. …”
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    Kappa but not delta or mu opioid receptors form homodimers at low membrane densities
  12. 4812
    “…Here, we reveal that the Arabidopsis (Arabidopsis thaliana) KEA3 protein homo-dimerizes via its C-terminal domain. This C-terminus has a regulatory function, which responds to light intensity transients. …”
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    Functional characterization of proton antiport regulation in the thylakoid membrane
  13. 4813
    “…No significant association was found with PCOS in dominant (P=0.194), recessive (P=0.442), and homo vs. het. (P=0.5) genotype models. Genotype-phenotype correlation analysis revealed that variant TT genotype had significantly higher HOMA (P=0.029) and reduced insulin sensitivity QUICKI (P=0.037) values. …”
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    Clinical Manifestations of Hyperandrogenism and Ovulatory Dysfunction Are Not Associated with His1058 C/T SNP (rs1799817) Polymorphism of Insulin Receptor Gene Tyrosine Kinase Domain in Kashmiri Women with PCOS
  14. 4814
    “…Electrochemical studies revealed that the HOMO of the new dyes is located at ca. −5.35 eV making them relatively electron rich in spite of the presence of two B(−)–N(+) dative bonds. …”
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    Going beyond the borders: pyrrolo[3,2-b]pyrroles with deep red emission
  15. 4815
    “…Some mammalian species, including homo sapiens, have lost the ability to synthetize AA and depend on its nutritional uptake. …”
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    Redox Properties of Human Erythrocytes Are Adapted for Vitamin C Recycling
  16. 4816
    “…Associated fauna, flora, and Homo sapiens fossils are thereby now fixed between 106 ± 20 ka and 96.4 ± 1.6 ka (all errors 2σ). …”
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    Integrative geochronology calibrates the Middle and Late Stone Ages of Ethiopia’s Afar Rift
  17. 4817
    “…SignaLink3 contains over 400 000 newly added human protein-protein interactions resulting in a total of 700 000 interactions for Homo sapiens, making it one of the largest integrated signaling network resources. …”
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    SignaLink3: a multi-layered resource to uncover tissue-specific signaling networks
  18. 4818
    “…The carbon atom of CN(–) interacts with the AgNPs, and the carbon atom donates electrons from the HOMO to the vacant orbitals of the coordinatively unsaturated surface atom (Ag(0)). …”
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    Rosmarinic Acid-Capped Silver Nanoparticles for Colorimetric Detection of CN(–) and Redox-Modulated Surface Reaction-Aided Detection of Cr(VI) in Water
  19. 4819
    “…This work should help to raise awareness that (especially for BHJ blends with small Δ(HOMO) or Δ(LUMO) offsets) the measured ELQY cannot be straightforwardly used to calculate the ΔV(non-rad)(OC). …”
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    Wide-bandgap organic solar cells with a novel perylene-based non-fullerene acceptor enabling open-circuit voltages beyond 1.4 V
  20. 4820
    “…The homo-dimeric bacterial membrane protein EmrE effluxes polyaromatic cationic substrates in a proton-coupled manner to cause multidrug resistance. …”
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    High-pH structure of EmrE reveals the mechanism of proton-coupled substrate transport
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