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  1. 4941
    “…RESULTS: Flatfoot accompanied the evolutionary timeline of human species: from Lucy Australopithecus to Homo Sapiens. It was described among various diseases suffered by Tutankhamun (1343–1324 B.C.), while the first anatomical description dates to Emperor Trajan (53–117 A.D.) and the medical studies of Galen (129–201 A.D.). …”
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    Flatfoot over the centuries: the background of current conservative and operative treatments
  2. 4942
    “…In this study, we attempted to optimize the structure of muteins to enhance their TNFR2 agonistic activity and stability in vivo by IgG-Fc fusion following single-chain homo-trimerization. The fusion protein, scR2agoTNF-Fc, enhanced the expansion of CD4(+)CD25(+) Tregs and CD4(+)Foxp3(+) Tregs and contributed to their immunosuppressive activity ex vivo and in vivo in mice. …”
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    Bivalent structure of a TNFR2-selective and agonistic TNF-α mutein Fc-fusion protein enhances the expansion activity of regulatory T cells
  3. 4943
    “…The ligand structures were optimized using density functional theory, molecular docking, molecular dynamics simulations, quantum mechanics such as HOMO–LUMO, drug-likeness and theoretical absorption, distribution, metabolism, excretion, and toxicity (ADMET), and pharmacokinetics characteristics performed. …”
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    Anti-parasitic drug discovery against Babesia microti by natural compounds: an extensive computational drug design approach
  4. 4944
    por Yang, Lixian, Zhang, Shiyu, Pu, Pengpeng
    Publicado 2023
    “…The evolution and function of multiple ACKRs in BC have yet to be fully elucidated, although certain findings on this family have been reported in several studies in Homo sapiens and other species. The present study identified that the expression level of ACKRs was significantly lower in breast carcinoma (BRCA) tissues compared with normal breast tissues through searches of the Tumor Immune Estimation Resource, UALCAN and Gene Expression Profiling Interactive Analysis databases. …”
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    Comprehensive analysis of ACKR family members in breast cancer using prognostic values
  5. 4945
    “…Computational analysis supported the experimental findings, indicating that arsine adsorbs more stably to the catalyst with an energy of −60.8 Kcal/mol, compared to propanol (−46.17 Kcal/mol) and isobutyl (−33.13 Kcal/mol). Analyses of HOMO and LUMO orbitals, as well as reactivity descriptors, such as electronegativity, chemical potential, and nucleophilicity, shed light on the potential interactions and chemical reactions involving inhibitors. …”
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    Parts per Million of Propanol and Arsine as Responsible for the Poisoning of the Propylene Polymerization Reaction
  6. 4946
    “…A comparable V(oc) (1.49–2.535 V) with respect to the HOMO(PBDBT)–LUMO(acceptor) for entitled compounds was investigated. …”
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    Designing of banana shaped chromophores via molecular engineering of terminal groups to probe photovoltaic behavior of organic solar cell materials
  7. 4947
    “…Comparing the diet and habitat of the archaic hominin from Cobra Cave with those of early Homo sapiens from Tam Pà Ling Cave (46–43 ka), Laos, it appears that only our species was able to exploit rainforest resources.…”
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    Palaeoenvironments and hominin evolutionary dynamics in southeast Asia
  8. 4948
    “…There was a significantly higher risk in newborns with G6PD deficiency (homo- and hemizygous adjusted Odd Ratio [aOR]: 21.0, 95% CI: 4.1–105.9), preterm births (aOR: 6.1, 95% CI: 1.4–26.9), newborns with excessive birth weight loss (aOR: 5.8, 95% CI: 1.4–23.2), and hyperbilirubinemia at birth (aOR: 14.8, 95% CI: 2.7–79.6). …”
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    Prevalence and Risk Factors of Neonatal Hyperbilirubinemia in a Semi-Rural Area of the Democratic Republic of Congo: A Cohort Study
  9. 4949
    “…In contrast, p63 and p73 form hetero-oligomers of all possible stoichiometries, with the hetero-tetramer built from a p63 dimer and a p73 dimer being thermodynamically more stable than the two homo-tetramers. This predicts that in cells expressing both proteins a p63(2)/p73(2) hetero-tetramer is formed. …”
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    DARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma
  10. 4950
    “…Complicating the issue, clinical definitions of flatfoot in living Homo sapiens have not reached a consensus. Here we digitally investigate the navicular morphology of H. sapiens (living, archaeological, and fossil), great apes, and fossil hominins and its correlation with the MLA. …”
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    Morphological and evolutionary insights into the keystone element of the human foot’s medial longitudinal arch
  11. 4951
    “…L1 encodes two proteins essential for retrotransposition: ORF2p, a reverse transcriptase that contains an endonuclease domain, and ORF1p, a coiled coil mediated homo trimer, which functions as a nucleic acid chaperone. …”
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    Co-expression of distinct L1 retrotransposon coiled coils can lead to their entanglement
  12. 4952
    “…Molecular modeling showed the corresponding domain regions and main exposed post-translational target sites in its three-dimensional structure, which also closely matched Homo sapiens BiP further indicating that it indeed corresponds to a BiP/HSP70 family protein. …”
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    Biochemical and molecular characterization of the SBiP1 chaperone from Symbiodinium microadriaticum CassKB8 and light parameters that modulate its phosphorylation
  13. 4953
    “…The conformational diversity and detailed interactions among homo-oligomer chains of α-Syn are not fully discovered; identifying these might help uncover a practical approach to developing a potent therapy. …”
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    Conformational dynamics of α-synuclein and study of its intramolecular forces in the presence of selected compounds
  14. 4954
    “…RNA with a measurable conductance corresponds to sequences with overall extended base-stacking stabilized conformations characterized by lower HOMO energy levels delocalized over a base-stacking mediating CT pathway. …”
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    Charge transport in individual short base stacked single-stranded RNA molecules
  15. 4955
    “…This study employed density functional theory (DFT) computational techniques at the ωB97XD/def2svp level of theory to comprehensively explore the electronic behavior of Fe-group transition metal (Fe, Ru, Os) coordination of Se-doped graphitic carbon (Se@g-C(3)N(4)) nanosystems in the smart delivery of zidovudine (ZVD), an antiretroviral drug. The HOMO–LUMO results of the interactions show a general reduction in energy gap values across all complexes in the following order: ZVD_Se@C(3)N(4) < ZVD_Ru_Se@C(3)N(4) < ZVD_Fe_Se@C(3)N(4) < ZVD_Os_Se@C(3)N(4). …”
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    The iron group transition-metal (Fe, Ru, Os) coordination of Se-doped graphitic carbon (Se@g-C(3)N(4)) nanostructures for the smart therapeutic delivery of zidovudine (ZVD) as an antiretroviral drug: a theoretical calculation perspective
  16. 4956
    “…They deteriorate across mitotic divisions of a cell. In Homo sapiens this process of lifetime reduction has been shown to correspond with aspects of organismal aging and exposure to stress or other insults. …”
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    Telomere Dynamics in Livestock
  17. 4957
    “…In contrast, other reported human variant exons were restricted to Homo sapiens, and, in some cases, other primates. …”
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    Organization and post-transcriptional processing of focal adhesion kinase gene
  18. 4958
    “…METHODS: In 304 Caucasian American NTD families with myelomeningocele or anencephaly, we examined 28 polymorphisms in 11 genes: folate receptor 1, folate receptor 2, solute carrier family 19 member 1, transcobalamin II, methylenetetrahydrofolate dehydrogenase 1, serine hydroxymethyl-transferase 1, 5,10-methylenetetrahydrofolate reductase (MTHFR), 5-methyltetrahydrofolate-homo-cysteine methyltransferase, 5-methyltetrahydrofolate-homocysteine methyltransferase reductase, betaine-homocysteine methyltransferase (BHMT), and cystathionine-beta-synthase. …”
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    Neural Tube Defects and Folate Pathway Genes: Family-Based Association Tests of Gene–Gene and Gene–Environment Interactions
  19. 4959
    por Zhang, Ping, Canessa, Cecilia M.
    Publicado 2002
    “…Depending on their location and specialization some neurons express more than one type of ASIC where they may form homo- or heteromeric channels. Macroscopic characteristics of the ASIC currents have been described, but little is known at the single channel level. …”
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    Single Channel Properties of Rat Acid–sensitive Ion Channel-1α, -2a, and -3 Expressed in Xenopus Oocytes
  20. 4960
    “…The eukaryotic orthologous groups (KOGs) include proteins from 7 eukaryotic genomes: three animals (the nematode Caenorhabditis elegans, the fruit fly Drosophila melanogaster and Homo sapiens), one plant, Arabidopsis thaliana, two fungi (Saccharomyces cerevisiae and Schizosaccharomyces pombe), and the intracellular microsporidian parasite Encephalitozoon cuniculi. …”
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    The COG database: an updated version includes eukaryotes
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