“…We studied the electrophysiological effects of the I230T mutation in the sodium channel gene SCN5A in hiPSC‐CMs generated from a homozygous (I230T(homo)) and a heterozygous (I230T(het)) individual from a family with recessive cardiac conduction disease. …”
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“…The general results showed that the FEB values were statistically more negative (p < 0.05) in the following order: (SWCNT-VDAC2-Danio rerio) > (SWCNT-VDAC1-Mus musculus) > (SWCNT-VDAC1-Homo sapiens) > (ATP-VDAC). More negative FEB values for SWCNT-COOH and OH were found in VDAC2-Danio rerio when compared with VDAC1-Mus musculus and VDAC1-Homo sapiens (p < 0.05). …”
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“…The doxorubicin loading nano-agent (Ce6-CSPD/DOX) could quench both photoactivity and fluorescence of photosensitizer chlorin e6 (Ce6) and doxorubicin (DOX) under physiological condition by homo-fluorescence resonance energy transfer (homoFRET). …”
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“…Because the vertical first ionization potential and vertical first electron affinity in the ground state (gs) are defined as follows I = E(gs)(N – 1) – E(gs)(N) and A = E(gs)(N) – E(gs)(N + 1), where E(gs)(N – 1), E(gs)(N), and E(gs)(N + 1) correspond to energies of the system bearing N, N + 1, and N – 1 electrons, along with Koopmans’ theorem (KT) given by I ≈ −ε(HOMO) (ε(HOMO), highest occupied molecular orbital energy) and A ≈ −ε(LUMO) (ε(LUMO), lowest unoccupied molecular orbital energy), the deviation from the KT was performed by the use of the [Image: see text] index, such that J(I) = |E(gs)(N – 1) – E(gs)(N) + ε(HOMO)| and J(A) = |E(gs)(N) – E(gs)(N + 1) + ε(LUMO)|, which are absolute deviations from the perspective of I and A, respectively. …”
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“…The results showed that for of the Homo sapiens EnsembleSplice achieved accuracies of 94.16% for one of the acceptor splice sites and 95.97% for donor splice sites, with an error rate for the same Homo sapiens dataset, 4.03% for the donor splice sites and 5.84% for the acceptor splice sites datasets. …”
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“…The accumulated evidence from these fossils suggests that the iconic SK 54 juvenile calvaria is more likely early Homo than Paranthropus. It is also consistent with the hypothesis that P. robustus is more closely related to Homo than to A. africanus.…”
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“…Our findings pave the way for manipulating the relative HOMO and LUMO energy levels of organic chromophores by fusing non-alternant azulenes to an otherwise flat PAH, which could possibly lead to applications in organic electronics and optical sensors.…”
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“…Theoretical calculation reveals that the highest occupied molecular obital (HOMO) energy level of propargylic B(MIDA) is significantly raised by 0.3 eV, and the preferential electrophilic addition to the γ position is due to its higher HOMO orbital coefficient and more negative natural bond orbital (NBO) charge compared to the β position. …”
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“…This in silico study is based on dentistry’s most used animal models and intends to search for the most suitable, evolutionarily close to Homo sapiens. We were able to retrieve 176,077 mammalian MMP sequences from the UniProt database. …”
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“…Additionally, we uncover the strong potential of truncated isoforms to block homo- and heterodimerization of chemokine receptors, also in a dynamic manner. …”
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“…The energies of the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital orbital were computed to explore how the HOMO energies of the reactants initiated the electronic interactions between them. …”
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“…Very little work has been reported in functional prediction of eukaryotes such as mouse and Homo sapiens species from phylogenetic profiles. …”
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“…The functional enzyme is a homo-tetramer with four active sites located at dimeric interfaces. …”
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“…In contrast to prior studies of Ag(+) incorporation into double-stranded DNA, we remove the constraints of Watson-Crick pairing by focusing on homo-base DNA oligomers of the canonical bases. High resolution electro-spray ionization mass spectrometry reveals an unanticipated Ag(+)-mediated pairing of guanine homo-base strands, with higher stability than canonical guanine-cytosine pairing. …”
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“…The DFT outcome reveals that the HOMO-LUMO gap of Ligand19 is 2.86 kcal/mol. Among the considered ligands, Ligand19 shows the lowest gap and it is suggested that the HOMO of Ligand19 may transfer the electrons to the LUMO in the active regions. …”
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“…In this work, we experimentally reconstruct the highest occupied molecular orbital (HOMO) of nitrogen (N(2)) by using a Coulomb-corrected MOT (CCMOT) method. …”
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“…This site is famous for its Middle Pleistocene fossil hominins considered representatives of Homo rhodesiensis. The bone was discovered in Unit 4 of the Grotte à Hominidés (GH), dated to c. 500 ky and was associated with Acheulean artefacts and a rich mammalian fauna. …”
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“…Accordingly, the correlation between the frontier orbital (E(HOMO) and E(LUMO) of inhibitor molecules and the Fermi level of metal) and inhibition efficiency is determined. …”
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“…Next, we monitor self-assembly of PKC—mCitrine fusion proteins using time-resolved and steady-state homoFRET. HomoFRET between full-length PKCα molecules is observed when in solution with both calcium and liposomes containing either diacylglycerol (DAG) or phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)). …”
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“…Surprisingly, our structures reveal an α(2)β(4) stoichiometry, and the overall architecture of the holoenzyme is strikingly different from that of the homo-tetrameric PCs. Biochemical and mutagenesis studies confirm the stoichiometry and other structural observations. …”
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