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1941“…One of the present challenges in the study of human evolution is to recognize the hominin taxon that was ancestral to Homo sapiens. Some researchers regard H. heidelbergensis as the stem species involved in the evolutionary divergence leading to the emergence of H. sapiens in Africa, and to the evolution of the Neandertals in Europe. …”
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1942“…The enzyme, which belongs to the polysaccharide deacetylases protein family, is a homo-tetramer. The four polypeptide chains, each folded into a single domain characterized by a non-canonical TIM-barrel fold, are arranged around a four-fold symmetry axis. …”
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1943por Stefanucci, Azzurra, Pinnen, Francesco, Feliciani, Federica, Cacciatore, Ivana, Lucente, Gino, Mollica, Adriano“…Structural modifications leading to cyclic imino derivatives such as spinacine, aza-histidine and analogues with shortening or elongation of the native side chain (nor-histidine and homo-histidine, respectively) are also described. …”
Publicado 2011
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1944por Smith, Kevin B., Oxley, Douglas, Hibbing, Matthew V., Alford, John R., Hibbing, John R.“…Thus, it is not surprising that it shapes behaviors in a variety of organisms and in a variety of contexts—including homo sapien politics. People who believe they would be bothered by a range of hypothetical disgusting situations display an increased likelihood of displaying right-of-center rather than left-of-center political orientations. …”
Publicado 2011
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1945“…These evolutionary conserved polytopic membrane proteins are present in all phyla from simplest life forms (bacteria) to highly evolved eukaryotes (Homo sapiens). The presumed early function in metal detoxification remains the main function of Copper-ATPases in prokaryotic kingdom. …”
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1946por Szyk, Agnieszka, Deaconescu, Alexandra M., Piszczek, Grzegorz, Roll-Mecak, Antonina“…It engages the tubulin tail through low-affinity, high-specificity interactions, and co-opts what is otherwise a homo-oligomerization interface in structurally related ATP-grasp fold enzymes to form a tight hetero-oligomeric complex with the tubulin body. …”
Publicado 2011
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1947“…The structure reveals how two different symmetries within the operator are simultaneously recognized by the homo-dimeric protein, underpinned by a conformational change in one of the protein subunits. …”
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1948por Dauletbaev, N, Fischer, P, Aulbach, B, Gross, J, Kusche, W, Thyroff-Friesinger, U, Wagner, TOF, Bargon, J“…METHODS: Twenty-one patients (ΔF508 homo/heterozygous, FEV(1 )> 40% pred.) were included in the study. …”
Publicado 2009
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1949por Grenga, Lucia, Gervasi, Fabio, Paolozzi, Luciano, Scortichini, Marco, Ghelardini, Patrizia“…In addition, their ability to form both homo and heterodimers between each other was shown by using the prokaryotic two-hybrid assay. …”
Publicado 2012
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1950“…Similar assemblies can be observed in the crystals of Pyrococcus furiosus RadA and Homo sapiens DMC1. In all of these two-ringed assemblies the DNA-interacting L1 region of each protomer points inward towards the centre, creating a highly positively charged locus. …”
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1951por Blanchet, Xavier, Langer, Marcella, Weber, Christian, Koenen, Rory R., von Hundelshausen, Philipp“…Physicochemical properties of chemokines and chemokine receptors confer the ability to homo- and hetero-oligomerize. Many efforts are currently performed in establishing new therapeutically compounds able to target the chemokine/chemokine receptor system. …”
Publicado 2012
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1952“…We use protein sequences from central redox systems in Homo sapiens, Drosophila melanogaster, and Saccharomyces cerevisiae to query Genbank for homologous proteins in C. elegans. …”
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1953por Loureiro, Maria Eugenia, D’Antuono, Alejandra, Levingston Macleod, Jesica M., López, Nora“…Furthermore, current evidence suggests that binding between Z and the viral envelope glycoprotein complex is required for virion infectivity, and that Z homo-oligomerization is an essential step for particle assembly and budding. …”
Publicado 2012
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1954“…Cubilin, (CUBN; also known as intrinsic factor-cobalamin receptor [Homo sapiens Entrez Pubmed ref NM_001081.3; NG_008967.1; GI: 119606627]), located in the epithelium of intestine and kidney acts as a receptor for intrinsic factor – vitamin B12 complexes. …”
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1955“…The crystal structure of five different proteins, PDBIDs: 3LII, 3NXU, 4GTU, 2XJ1 and 1YXA in Homo sapiens (H. sapiens), interact with organophosphorus pesticides at the molecular level. …”
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1956por Moreno, Eduardo“…The analysis reveals that the ancestral state of Homo sapiens was hunting, using material innovations that included bows and arrows, stone axes and spears. …”
Publicado 2013
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1957“…AAA ATPases form a functionally diverse superfamily of proteins. Most members form homo-hexameric ring complexes, are catalytically active only in the fully assembled state, and show co-operativity among the six subunits. …”
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1958por Li, Dianfan, Lyons, Joseph A., Pye, Valerie E., Vogeley, Lutz, Aragão, David, Kenyon, Colin P., Shah, Syed T. A., Doherty, Christine, Aherne, Margaret, Caffrey, Martin“…Here, we present crystal structures for three functional forms of this unique and paradigmatic kinase, one of which is wild type (WT). These reveal a homo-trimeric enzyme with three transmembrane helices and an N-terminal amphiphilic helix per monomer. …”
Publicado 2013
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1959por Sahle, Yonatan, Hutchings, W. Karl, Braun, David R., Sealy, Judith C., Morgan, Leah E., Negash, Agazi, Atnafu, Balemwal“…Composite projectile technologies are considered indicative of complex behavior and pivotal to the successful spread of Homo sapiens. Direct evidence for such projectiles is thus far unknown from >80,000 years ago. …”
Publicado 2013
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1960por Nonoguchi, Yoshiyuki, Ohashi, Kenji, Kanazawa, Rui, Ashiba, Koji, Hata, Kenji, Nakagawa, Tetsuya, Adachi, Chihaya, Tanase, Tomoaki, Kawai, Tsuyoshi“…We here report air-stable n-type single walled carbon nanotubes with a variety of weak electron donors in the range of HOMO level between ca. −4.4 eV and ca. −5.6 eV, in which partial uphill electron injection from the dopant to the conduction band of single walled carbon nanotubes is dominant. …”
Publicado 2013
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