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26401por M Castillejo Becerra, Clara, Ding, Yue, Kenol, Beatrice, Hendershot, Andrew, Meara, Alexa Simon“…This paper addresses this gap and hopes to inform both rheumatologists and ophthalmologists as they work together on the management of patients with rheumatological conditions. …”
Publicado 2020
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26402“…A more complete understanding of these cell types that bridge the innate and adaptive immune system will hopefully lead to more targeted therapies that mitigate or prevent disease progression.…”
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26403por Qiao, Ming, Yang, Jianhua, Zhao, Yao, Zhu, Yi, Wang, Xiaomei, Wang, Xinling, Hu, Junping“…In essence, apigenin, aesculetin, and butylphthalide may hopefully become the natural products of antiliver fibrosis, which laid a foundation for the subsequent development of celery seeds as antiliver fibrosis drugs.…”
Publicado 2020
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26404por van Spil, W. E., Bierma-Zeinstra, S. M. A., Deveza, L. A., Arden, N. K., Bay-Jensen, A.-C., Kraus, V. Byers, Carlesso, L., Christensen, R., Van Der Esch, M., Kent, P., Knoop, J., Ladel, C., Little, C. B., Loeser, R. F., Losina, E., Mills, K., Mobasheri, A., Nelson, A. E., Neogi, T., Peat, G. M., Rat, A.-C., Steultjens, M., Thomas, M. J., Valdes, A. M., Hunter, D. J.“…Success in this endeavor will hopefully translate into more effective, differentiated OA management that will benefit a multitude of OA patients.…”
Publicado 2020
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26405por Li, ShuLong, Liu, Xin, Wei, Lai, Wang, HuiFen, Zhang, JiYang, Wei, HanDong, Qian, XiaoHong, Jiang, Ying, He, FuChu“…These results provide a clearer understanding of liver fibrosis pathophysiology and will also hopefully lead to improvement of clinical diagnosis and treatment. …”
Publicado 2011
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26406“…The biogenesis and identification of miRNAs, potential applications, and future directions for research are presented, hopefully providing a guideline for further miRNA and gene function studies.…”
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26407por Dingerdissen, Hayley M., Bastian, Frederic, Vijay-Shanker, K., Robinson-Rechavi, Marc, Bell, Amanda, Gogate, Nikhita, Gupta, Samir, Holmes, Evan, Kahsay, Robel, Keeney, Jonathon, Kincaid, Heather, King, Charles Hadley, Liu, David, Crichton, Daniel J., Mazumder, Raja“…By mapping to and integrating data from several cancer genomics resources, it is hoped that OncoMX will foster a dynamic engagement between bioinformaticians and cancer biomarker researchers. …”
Publicado 2020
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26408“…The overall molecular mechanisms of emodin include cell cycle arrest, apoptosis, and the promotion of the expression of hypoxia-inducible factor 1α, glutathione S-transferase P, N-acetyltransferase, and glutathione phase I and II detoxification enzymes while inhibiting angiogenesis, invasion, migration, chemical-induced carcinogen-DNA adduct formation, HER2/neu, CKII kinase, and p34cdc2 kinase in human cancer cells. Hopefully, this summary will provide information regarding the actions of emodin in cancer cells and broaden the application potential of chemotherapy to additional cancer patients in the future.…”
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26409por Hansen, Paul“…The parlour system at Great Hopes Farm allows five workers (aided by three more stall staff) to milk over 1000 cows, fifty at a time, three times a day. …”
Publicado 2014
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26410por Burnouf, Thierry, Griffiths, Elwyn, Padilla, Ana, Seddik, Salwa, Stephano, Marco Antonio, Gutiérrez, José-María“…As many manufacturers of antivenoms located in developing countries lack the resources to conduct formal viral validation studies, it is hoped that this review will help in the scientific understanding of the viral safety factors of antivenoms, in the controlled implementation of the manufacturing steps with expected impact on viral safety, and in the overall reinforcement of good manufacturing practices of these essential therapeutic products.…”
Publicado 2004
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26411por Ragnar Norrby, S.“…With few exceptions, Europe still lacks epidemiological field forces, and it has been embarrassing to be obliged to call upon the Centers for Disease Control for European outbreaks. Hopefully, this will be corrected with the creation of the European Centre for Disease Prevention and Control (ECDC).…”
Publicado 2005
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26412por Maran, Sathiya, Ee, Robson, Faten, Siti Aisyah, Sy Bing, Choi, Khaw, Kooi Yeong, Erin Lim, Swee-Hua, Lai, Kok-Song, Wan Ibrahim, Wan Pauzi, Mohd Zain, Mohd Rizal, Chan, Kok Gan, Gan, Siew Hua, Tan, Huay Lin“…To our knowledge, this is the first study to provide compelling evidence on the pathogenesis of MYH3 variants towards ASD hence, suggesting the crucial role of non-synonymous variants in the tail domain of MYH3 towards atrial septal development. It is hoped that this gene can be used as panel for diagnosis of ASD in future.…”
Publicado 2020
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26413por Ribic, Adema“…Knowledge gaps and avenues for future work are highlighted, and these will hopefully motivate future research in these areas, particularly those about the learning of complex skills during development.…”
Publicado 2020
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26414por Yan, Lei, Chen, Zhou, Zou, Yunfeng, He, Xuhui, Cai, Chenzhi, Yu, Kehui, Zhu, Xiaojie“…The frequency peaks of the acceleration level are also independent of the train speeds. It hopes that the field measurements in this paper can provide a data set for researchers for further investigations and can contribute to the countermeasures for reducing interior noise and vibration of a metro vehicle.…”
Publicado 2020
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26415“…The significance of these themes is discussed in relation to how hopes for parenthood could be realized without jeopardizing gender identity and the need for a future focused, flexible, and open-minded approach on the part of fertility and adoption services.…”
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26416por Clark, Sarah L., Levasseur-Franklin, Kimberly, Pajoumand, Mehrnaz, Barra, Megan, Armahizer, Michael, Patel, Deepa V., Wyatt Chester, Katleen, Tully, Andrea P.“…Upon realization of the impending drug shortages, hospitals resorted to alternative methods of drug administration, such as IV push routes, formulary substitutions, or alternative drug therapies in hopes of preserving the small supply of IV bags available and prioritizing them for them most critical needs. …”
Publicado 2019
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26417Bi-allelic GAD1 variants cause a neonatal onset syndromic developmental and epileptic encephalopathypor Chatron, Nicolas, Becker, Felicitas, Morsy, Heba, Schmidts, Miriam, Hardies, Katia, Tuysuz, Beyhan, Roselli, Sandra, Najafi, Maryam, Alkaya, Dilek Uludag, Ashrafzadeh, Farah, Nabil, Amira, Omar, Tarek, Maroofian, Reza, Karimiani, Ehsan Ghayoor, Hussien, Haytham, Kok, Fernando, Ramos, Luiza, Gunes, Nilay, Bilguvar, Kaya, Labalme, Audrey, Alix, Eudeline, Sanlaville, Damien, de Bellescize, Julitta, Poulat, Anne-Lise, Moslemi, Ali-Reza, Lerche, Holger, May, Patrick, Lesca, Gaetan, Weckhuysen, Sarah, Tajsharghi, Homa“…Modern genomic technologies have revealed a number of monogenic origins and opened the door to therapeutic hopes. Here we describe a new syndromic developmental and epileptic encephalopathy caused by bi-allelic loss-of-function variants in GAD1, as presented by 11 patients from six independent consanguineous families. …”
Publicado 2020
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26418“…CONCLUSIONS: The experimental results show that the proposed method which is hopefully to be a complementary tool for the existing methods of subcellular localization, can effectively extract more abundant features of protein sequence and is feasible in predicting the subcellular location of apoptosis proteins.…”
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26419“…Further evidence to elucidate whether invasive management is beneficial in older patients with ACS is required out-with the COVID-19 pandemic. Though it is hoped that the actual acute phase of COVID-19 infection will be short lived, it is vital that important clinical research is continued, given the long-term benefits of ongoing clinical research for patients with long-term conditions, including CVD. …”
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26420por Kato, Masashi, Ohgami, Nobutaka, Ohnuma, Shoko, Hashimoto, Kazunori, Tazaki, Akira, Xu, Huadong, Kondo-Ida, Lisa, Yuan, Tian, Tsuchiyama, Tomoyuki, He, Tingchao, Kurniasari, Fitri, Gu, Yishuo, Chen, Wei, Deng, Yuqi, Komuro, Kanako, Tong, Keming, Yajima, Ichiro“…Finally, our original hydrotalcite-like compound was proposed as a novel remediation system to effectively remove arsenic and barium from well drinking water. Hopefully, comprehensive studies consisting of (1) environmental monitoring, (2) health risk assessments, and (3) remediation will be expanded in the field of environmental health to prevent various disorders caused by environmental factors including toxic elements in drinking water.…”
Publicado 2020
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