“…This manuscript seeks to review these technological advancements, and others, to improve AAV delivery to the brain, and to propose novel strategies to build upon this research. Ultimately, it is hoped that the optimization of AAV delivery will allow for the human translation of many gene therapies for neurodegenerative and other neurologic diseases.…”
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“…Furthermore, the distribution, applications, and future development trends of fluorinated compounds are also outlined. Hopefully, this review will help researchers to understand the significance of enzymatic methods for the synthesis of fluorinated compounds and find or create excellent fluoride synthase in future research. …”
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“…BACKGROUND: It is generally expected that emergency laparotomies performed at night confer a higher risk and thus outcomes are worse. This study hopes to determine whether there is a difference in risk of cases presenting at night, and overall outcome. …”
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“…Nonetheless, these new findings further our understanding of the effects of low serum OT levels among individuals with ASD, which provides preliminary evidence in hopes of guiding future study design or mechanistic studies. …”
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“…CONCLUSION: Overall, FeS-Dox@Lf NZs with the ability to synchronize chemotherapy and gas therapy raised hopes for more effective treatment of breast cancer. …”
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“…By recognising the shortcomings of information accessed by patients online, it is hoped clinicians may be prompted to better educate their patients.…”
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“…In this review, we will point out the potential common neuropathological pattern which needs to be addressed and we will hopefully contribute to clarifying the complex phenotype of these two neurorological disorders, in order to pave the way for a novel, common disease-modifying therapy.…”
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“…Among the secondary metabolites, flavonoids are hopeful phytochemicals with established biological activities and minimal side effects. …”
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“…In the current situation of the pandemic, an appropriate screening tool must be established either by using rapid molecular testing or saliva point-of-care technology, which will be effective in identifying as well as isolating the potential contacts and carriers in hopes to contain and mitigate infection. The blessing in disguise is that this virus has united the leaders, scientists, health care providers, and people of all professions from all around the world to fight against a common enemy.…”
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“…In conclusion, our data provide the first evidence that erianin can initiate ferroptosis-like cell death and lipid peroxidation in bladder cancer, which will hopefully become a promising anticancer compound for the treatment of bladder cancer.…”
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“…The review also puts forward the basis of using exogenous stem cells to treat diabetic complications. It is hoped that through this review, researchers can have a clearer understanding of the roles of stem cells in diabetic complications, thus promoting the process of using stem cells to treat diabetic complications.…”
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“…The study aims to assess the stress perceived by healthcare workers and possible factors contributing to it, hoping that more efforts will be exerted to support the well-being of healthcare workers during public health emergencies. …”
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“…According to the literature review, another problem in numerical simulations is that the virus decay rate and suspended viable viral dose are often not incorporated; therefore here, empirical relationships for the bioactivity of coronavirus are presented. It is hoped that this paper can assist researchers to significantly improve their model fidelity when simulating respiratory droplet transmission.…”
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“…Following the use of this framework, it is hoped that the incidence of malrotation post tibia intramedullary nailing will be reduced, however, it is acknowledged that more high evidence studies need to be carried out and further done to optimise the care of these patients.…”
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“…The retrospective nature of this study is an important bias, and for this reason, we have started a prospective multicentric study including Italian stage IV patients that hopefully will give us more answers.…”
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“…Hence, this review aims to elucidate on the potential long-term complication of SARS-CoV-2 infection and hopefully to improve the management and prognosis of COVID-19.…”
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“…Nevertheless, if the Spanish flu was not unforseen, COVID-19 spillover was partially predictable and its global impact will hopefully not be overshadowed by a major crisis such as World War I.…”
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“…Moving beyond cytotoxic agents has the potential to open new and unexpected avenues in the treatment of myeloid malignancies, hopefully providing more efficacy with reduced toxicity.…”
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“…In fact, suggesting that COVID-19 is a new member in the spectrum of hyperferritinemic syndrome besides the four mentioned conditions could hopefully direct further search on the pathogenetic role of ferritin. …”
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“…ABSTRACT: Machine learning (ML) integrated with medical imaging has introduced new perspectives in precision diagnostics of high-grade gliomas, through radiomics and radiogenomics. This has raised hopes for characterizing noninvasive and in vivo biomarkers for prediction of patient survival, tumor recurrence, and genomics and therefore encouraging treatments tailored to individualized needs. …”
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