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  1. 26741
    “…The aim of this investigation was to understand whether the structural modifications that arise when a patient’s nail become infected plates influences the permeation of drugs into the nail following topical application. It was hoped that through improving understanding of the nail barrier in the diseased state, the development of more effective topical treatments for onychomycosis could be facilitated. …”
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    An investigation of how fungal infection influences drug penetration through onychomycosis patient’s nail plates
  2. 26742
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    Editing of the urease gene by CRISPR-Cas in the diatom Thalassiosira pseudonana
  3. 26743
    “…The expectation is that graduates, with their expanded diagnostic and therapeutic knowledge, skills, and experience, will become future experts in primary spine care in Switzerland. It is hoped that this curriculum model will be adopted by other countries and jurisdictions seeking to enhance the role of chiropractic in health care.…”
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    The Swiss Master in Chiropractic Medicine Curriculum: Preparing Graduates to Work Together With Medicine to Improve Patient Care
  4. 26744
    por Denker, Hans-Werner
    Publicado 2016
    “…“Organoids”, i.e., complex structures that can develop when pluripotent or multipotent stem cells are maintained in three-dimensional cultures, have become a new area of interest in stem cell research. Hopes have grown that when focussing experimentally on the mechanisms behind this type of in vitro morphogenesis, research aiming at tissue and organ replacements can be boosted. …”
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    Self-Organization of Stem Cell Colonies and of Early Mammalian Embryos: Recent Experiments Shed New Light on the Role of Autonomy vs. External Instructions in Basic Body Plan Development
  5. 26745
    por Marston, Steven
    Publicado 2017
    “…Currently, the function of obscurin is not well understood, but we anticipate that many more OBSCN variants linked to cardiomyopathy will be found when the large cohorts of patient sequences available are tested. It is to be hoped that the establishment of the importance of obscurin in pathology will stimulate a thorough investigation of obscurin function.…”
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    Obscurin variants and inherited cardiomyopathies
  6. 26746
    “…Recent reports of cannabinergic mechanisms in AUDs has opened an exciting realm of research that seeks to elucidate the molecular mechanisms of alcohol-induced end organ diseases and hopefully provide insight into new therapeutic strategies for the treatment of AUDs. …”
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    Epigenetic Interactions between Alcohol and Cannabinergic Effects: Focus on Histone Modification and DNA Methylation
  7. 26747
    “…Together with the implementation of proper preventive health measures and the education of parents regarding their carrier status, we are hoping that this method will be used as the common application approach to decrease the incidence of thalassaemia major.…”
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    Prenatal molecular diagnosis of β-thalassemia: report on the first two cases in Romania
  8. 26748
    por Bose, Prithviraj, Gandhi, Varsha
    Publicado 2017
    “…Thus, successful therapeutic targeting of the B-cell receptor signaling pathway and of the Bcl-2 anti-apoptotic protein with small molecules has now made chemotherapy-free approaches possible, hopefully mitigating the risk of development of therapy-related myeloid neoplasms and making eventual cure of CLL with the use of optimal drug combinations a realistic goal. …”
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    Recent therapeutic advances in chronic lymphocytic leukemia
  9. 26749
    “…Thus, the regular verification/assessment of resistance development status will hopefully help in the future to assist local public health authorities in their mosquito control programs by recommending and managing the rotation of different routinely used insecticides with diverse effector mechanisms in order to delay Ae. aegypti resistance development.…”
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    Aedes aegypti resistance development to commonly used insecticides in Jakarta, Indonesia
  10. 26750
    “…In our clinical and research efforts, we attempt to specify what a clinician may do to help patients help themselves, by mobilizing the vast resources hidden in their subjective worlds and existence, in their hopes and dreams, and their will to live. The field of holistic medicine must be upgraded to fully integrate human consciousness, scientifically as well as philosophically. …”
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    Holistic Medicine: Scientific Challenges
  11. 26751
    “…With the upcoming launch of the National Cancer Institute’s Exceptional Responders Initiative, similar studies with much larger sample sizes will likely become possible, hopefully providing even more insight into the molecular differences between typical and exceptional responders.…”
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    Comparative molecular characterization of typical and exceptional responders in glioblastoma
  12. 26752
    “…In the current omics era, application of various state-of-the-art omics technologies is likely to provide comprehensive information on the evolution of Aspergillus, Penicillium and Talaromyces and a stable taxonomy will hopefully be achieved.…”
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    Taxonomy and evolution of Aspergillus, Penicillium and Talaromyces in the omics era – Past, present and future
  13. 26753
    por McLean, Michelle
    Publicado 2001
    “…As a result of its apparent positive influence on learning and attitudes towards learning, this bonus system will continue to operate until the traditional programme is phased out. It is hoped that other educators, believing that their assessment is a reflection of the intended outcomes, might recognise merit in rewarding students for consistent achievement.…”
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    Introducing a reward system in assessment in histology: A comment on the learning strategies it might engender
  14. 26754
    “…This article gives an overview of synthetic polymer-ceramic composites with a particular emphasis on calcium phosphate group and their potential applications in tissue engineering. It is hoped that synthetic polymer-ceramic composites such as PLLA/HA and PCL/HA will provide advantages such as eliminating the stress shielding effect and the consequent need for revision surgery.…”
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    A comprehensive review of biodegradable synthetic polymer-ceramic composites and their manufacture for biomedical applications
  15. 26755
    “…Finally, while recent studies do allow us, albeit with some ambiguity, to draw conclusions about distribution of HBV genotypes in Bangladesh, there needs to be an added emphasis on molecular epidemiology. It is hoped that the present review, the first of its kind in Bangladesh, will serve as an up-to-date summary of the course HBV epidemiology research in Bangladesh has taken thus far, as well as crucial gaps to address going forward.…”
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    Epidemiology of Hepatitis B Virus Infection in Bangladesh: Prevalence among General Population, Risk Groups and Genotype Distribution
  16. 26756
    “…While some are impractical, we attempt to provide a comprehensive list of potential nighttime warming methods in hopes of stimulating ideas and discussions.…”
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    Why and How to Create Nighttime Warming Treatments for Ecological Field Experiments
  17. 26757
    “…In addition to accurately modeling PD, iPSC lines can also be established with specific genetic risk factors to assess genetic sub-populations’ differing response to treatment. iPS cell lines can then be genetically corrected and subsequently transplanted back into the patient in hopes of re-establishing function. Current techniques focus on iPSCs because they are patient-specific, thereby reducing the risk of immune rejection. …”
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    Treatment of Parkinson’s Disease through Personalized Medicine and Induced Pluripotent Stem Cells
  18. 26758
    “…In this article, we outlined all the ongoing phase I studies of multinational corporation‐developed ICIs and domestic‐developed ICIs targeting the Chinese population, hoping to shed some light on the status quo of ICI research and developments in China.…”
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    Ongoing Phase I Studies of Immune Checkpoint Inhibitors in China
  19. 26759
    “…Staff and partnerships were identified as strengths of the response while funding, community, and region were identified as weaknesses of the response. It is hoped that by identifying different strengths and weaknesses through qualitative analysis this will aid in improving future responses.…”
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    Qualitative Case Study of Public Health Preparedness and Response to the Rabid Raccoon Discovered in Wise County, Virginia
  20. 26760
    “…This study sought to validate these scoring systems and hopefully adopt them for our teaching hospitals. MATERIALS AND METHODS: A prospective observational cohort study was conducted at two central hospitals in Harare Two hundred and two patients undergoing a variety of major general surgical operations were recruited into the study. …”
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    Validation of POSSUM, P-POSSUM and the surgical risk scale in major general surgical operations in Harare: A prospective observational study
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