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  1. 27061
    “…A software package and several novel procedures to streamline and hopefully improve the reduction of the NRIXS data generated at sector 3ID of the Advanced Photon Source have been developed. …”
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    SciPhon: a data analysis software for nuclear resonant inelastic X-ray scattering with applications to Fe, Kr, Sn, Eu and Dy
  2. 27062
    “…CONCLUSION: These results indicate that the 40S ribosomal protein S12 sandwich ELISA warrants further tests with more clinical samples of VL patients and other parasitic diseases. It is hopeful that this ELISA could become a useful tool for confirming VL diagnosis, monitoring treatment progress, disease recurrence and possibly detecting asymptomatic Leishmania infections with a high parasite load.…”
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    Development of a sandwich ELISA to detect Leishmania 40S ribosomal protein S12 antigen from blood samples of visceral leishmaniasis patients
  3. 27063
    “…More effort should be made to ensure that students effectively access debrief and other support opportunities. It is hoped that future work will be undertaken with different professional groups and explore the potential psychological and neuropsychological impact of witnessing trauma.…”
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    Are medical students in prehospital care at risk of moral injury?
  4. 27064
    “…This compound was first reported with a novel scaffold compared with previously known MRP4 inhibitors, which is a hopeful molecular tool that can be used for overcoming multidrug resistance research.…”
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    Discovery of novel multidrug resistance protein 4 (MRP4) inhibitors as active agents reducing resistance to anticancer drug 6-Mercaptopurine (6-MP) by structure and ligand-based virtual screening
  5. 27065
    “…Nec-1 has a protective effect in reducing cell death and promotes ectopic periodontal tissue like structure regeneration by inhibiting necroptosis. Nec-1 is a hopeful therapeutic agent which protects cells from necroptosis and ameliorates functional outcome.…”
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    Necrostatin-1 promotes ectopic periodontal tissue like structure regeneration in LPS-treated PDLSCs
  6. 27066
    “…Herein, the potential mechanisms underlying the crosstalk between PD-1/PD-L1 blockade and its combinatorial therapies for HNSCC were reviewed, and it is hoped that the improved understanding of the crosstalk process would provide further ideas for the design of a combinatorial regimen with a higher efficiency and response rate for the treatment of HNSCC and other malignancies.…”
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    Crosstalk Between PD-1/PD-L1 Blockade and Its Combinatorial Therapies in Tumor Immune Microenvironment: A Focus on HNSCC
  7. 27067
    “…The information herein will hopefully help improve the methodology of vEEG recordings from immature rodents and may lead to results and interpretations that are more consistent across studies from different laboratories.…”
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    Methodologic recommendations and possible interpretations of video‐EEG recordings in immature rodents used as experimental controls: A TASK1‐WG2 report of the ILAE/AES Joint Translational Task Force
  8. 27068
    por Paoluzzi, Luca, Ghesani, Munir
    Publicado 2018
    “…Basket trials focusing on diseases with unique genomic features such as EMC will hopefully provide a better understanding of new options for care.…”
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    Extraskeletal myxoid chondrosarcoma with massive pulmonary metastases
  9. 27069
    “…The upcoming of databases integrating single-nucleotide polymorphisms (SNPs) and non-coding RNAs together with novel technologies will hopefully facilitate the discovery of causal non-coding variants associated to disease. …”
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    Into the Wild: GWAS Exploration of Non-coding RNAs
  10. 27070
    por Bencard, Adam, Whiteley, Louise Emma
    Publicado 2018
    “…Rather, it emphasizes process over result, hopefully encouraging the visitors to ask their own questions of the relationship between mind and gut, between body and microbes.…”
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    Mind the Gut—displaying microbiome research through artistic collaboration
  11. 27071
    “…Acupuncture has good clinical efficacy in treating pain caused by prostate cancer. This review hopes to adopt meta-analysis to evaluate the efficacy and safety of acupuncture in the treatment of pain caused by prostate cancer and provides evidence for its application in clinical practice. …”
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    Acupuncture for pain caused by prostate cancer: Protocol for a systematic review
  12. 27072
    “…Using the principles outlined here, new modules (e.g., origin of replication for plasmids in other bacteria) can easily be designed for specific applications. It is hoped that this vector construction system will be expanded by the scientific community over time by creation of novel modules through an open source approach. …”
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    A Bacterial Expression Vector Archive (BEVA) for Flexible Modular Assembly of Golden Gate-Compatible Vectors
  13. 27073
    “…Growing evidence supports the existence of a programmed cell death system (PCD) in Acanthamoeba and while some features are shared by higher eukaryote cells, others differ. It is hoped that by understanding these differences we can exploit them as targets for novel drug intervention to activate PCD pathways in the amoebae but not the invaded human tissue. …”
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    G418 induces programmed cell death in Acanthamoeba through the elevation of intracellular calcium and cytochrome c translocation
  14. 27074
    “…Plasmodium falciparum thymidylate kinase (PfTMK) showed structural and catalytic distinctions from the host enzyme rendering it a hopeful antiprotozoal drug target. Despite the comprehensive enzymologic, structural, inhibitory and chemical synthesis approaches targeting this enzyme, the elucidation of the exact mechanism underlying the recognition of the atypical purine substrates remains to be determined. …”
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    The structural basis of unique substrate recognition by Plasmodium thymidylate kinase: Molecular dynamics simulation and inhibitory studies
  15. 27075
    “…Increased understanding of CSF dynamics may lead to improved detection of central nervous system (CNS) diseases and optimized delivery of CSF based CNS therapeutics, with many proposed therapeutics hoping to successfully treat or cure debilitating neurological conditions. …”
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    Characterization of intrathecal cerebrospinal fluid geometry and dynamics in cynomolgus monkeys (macaca fascicularis) by magnetic resonance imaging
  16. 27076
    “…Wearable devices that enable continuous measurement of blood pressure provide new opportunities and hopes. Although machine learning methods for blood pressure prediction have been studied, the accuracy of the results does not satisfy the needs of practical applications. …”
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    Predicting blood pressure from physiological index data using the SVR algorithm
  17. 27077
    “…In addition, the student-driven curriculum development process used can serve as a template for students at other institutions hoping to collaborate with faculty to develop comprehensive sexual and gender minority curricula.…”
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    Introductory Learning of Inclusive Sexual History Taking: An E-Lecture, Standardized Patient Case, and Facilitated Debrief
  18. 27078
    “…Researchers want to determine how telemonitoring has been used to observe COPD and we are hoping this will lead to more research in telemonitoring of this disease. …”
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    Telemonitoring to Manage Chronic Obstructive Pulmonary Disease: Systematic Literature Review
  19. 27079
    “…CONCLUSION: The KP CESR DQA model is applicable to networks hoping to improve data quality. The multi-organizational reporting system promotes transparency of DQA, adds to network knowledge about data quality, and informs research.…”
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    Data Quality Assessment and Multi-Organizational Reporting: Tools to Enhance Network Knowledge
  20. 27080
    por de Boni, Laura, Wüllner, Ullrich
    Publicado 2019
    “…These studies demonstrate that human neurons have the potential to be used as model systems for the study of epigenetic modifications in PD such as characterizing epigenetic changes, correlating epigenetic changes to gene expression alterations and hopefully using these insights for the development of novel therapeutics. …”
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    Epigenetic Analysis in Human Neurons: Considerations for Disease Modeling in PD
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