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  1. 27461
    por Ongrádi, Joseph, Kövesdi, Valéria
    Publicado 2010
    “…Among them, virosomal vaccines containing polypeptide antigens or DNA plasmids as well as new adjuvanted vaccine formulations elicit higher dendritic cell activity and more effective serologic than conventional vaccines responses in the elderly. Hopefully, at least some of these approaches can be translated to human medicine in a not too far future.…”
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    Factors that may impact on immunosenescence: an appraisal
  2. 27462
    por Berretta, Regina, Moscato, Pablo
    Publicado 2010
    “…The deep mathematical basis of the approach allows us to suggest that this principle is, hopefully, of general applicability for other diseases.…”
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    Cancer Biomarker Discovery: The Entropic Hallmark
  3. 27463
    “…CONCLUSION: The findings of the study provide support for the utility of assessing strategic gaze behaviour to better understand the way in which surgeons utilise visual information to plan and control tool movements in a virtual reality laparoscopic environment. It is hoped that by better understanding the limitations of the psychomotor system, effective gaze training programs may be developed.…”
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    Psychomotor control in a virtual laparoscopic surgery training environment: gaze control parameters differentiate novices from experts
  4. 27464
    “…Efficient methods for characterization of proteases and their substrates will therefore help us understand these fundamental processes and thereby hopefully point towards new therapeutic strategies. …”
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    Substrate Profiling of Tobacco Etch Virus Protease Using a Novel Fluorescence-Assisted Whole-Cell Assay
  5. 27465
    “…With the advances in the latter technology and the ability to tailor chelation therapy according to the MRI findings as well as the availability of three iron chelators, together with increasing the transfusions as need, it is hoped that the incidence of cardiac dysfunction in these syndromes will be markedly reduced. …”
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    Cardiac Function and Iron Chelation in Thalassemia Major and Intermedia: a Review of the Underlying Pathophysiology and Approach to Chelation Management
  6. 27466
    “…We then propose knowledge-enabled, dynamic solutions that will hopefully pave the way to enhanced alignment construction and exploitation in future evolutionary systems biology studies.…”
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    A Comprehensive Benchmark Study of Multiple Sequence Alignment Methods: Current Challenges and Future Perspectives
  7. 27467
    por Njuguna, J, Qader, SS
    Publicado 2008
    “…A major challenge is ensuring rational use and access at the household level. It is hoped that addressing these issues will increase the likelihood that ACT achieves its intended goals of reducing morbidity and mortality due to malaria, and delaying the onset of drug resistance.…”
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    Challenges Associated with Scaling up Artemisinin Combination Therapy in Sub-Saharan Africa A Review Article
  8. 27468
    “…Future studies of tumour biology of BC2 in relation to prognostic factors found in the present study can hopefully provide biological explanations to these findings.…”
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    Prediction of outcome after diagnosis of metachronous contralateral breast cancer
  9. 27469
    por Gupta, Ajay, Kumar, Lalit
    Publicado 2011
    “…RIST following ASCT has been tried with varying success but does not offer any major advantage over ASCT and is associated with higher morbidity. It is hoped that recent advances in therapy will contribute greatly to improved survival.…”
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    Evolving role of high dose stem cell therapy in multiple myeloma
  10. 27470
    por Piwowar, Heather A.
    Publicado 2011
    “…Many initiatives encourage investigators to share their raw datasets in hopes of increasing research efficiency and quality. …”
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    Who Shares? Who Doesn't? Factors Associated with Openly Archiving Raw Research Data
  11. 27471
    “…We have been looking for potential reasons for why clinical trials have failed, how vitally the application of appropriate methods of measuring and assessment influences study outcomes, and how relevant, e.g., results gained in models of vascular occlusive disease may be for antineoplastic strategies, advocating a reverse bedside-to-bench approach, which may hopefully yield successful approaches to therapeutically targeting vascular growth.…”
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    Vascular Growth in Health and Disease
  12. 27472
    “…In the mirror image “early nonresponder randomized dose increase or augmentation design,” early nonresponders at 2 weeks are assigned to staying on the medication or going either to a higher dose or an augmentation agent. It is hoped that through increased attention to the issues raised in this article and further refinement of trial methodology and conduct, the field will make much needed additional progress in the prevention and treatment of schizophrenia.…”
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    Randomized controlled trials in schizophrenia: opportunities, limitations, and trial design alternatives
  13. 27473
    “…We have examined competition between normal and Barrett's esophagus cell lines, in the hopes of identifying a system that could screen for potential chemopreventive agents. …”
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    An in vitro co-culture model of esophageal cells identifies ascorbic acid as a modulator of cell competition
  14. 27474
    “…These developments have been raising hopes to transfer this concept to other cancer types. …”
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    Dynamics of Resistance Development to Imatinib under Increasing Selection Pressure: A Combination of Mathematical Models and In Vitro Data
  15. 27475
    “…As a result, active H. pylori infection is strongly related to the outbreak and severity of migraine headaches, and H. pylori treatment reduces migraine headaches significantly. Hopefully, the definite treatment and eradication of this infection can cure or reduce the severity and course of migraine headaches significantly if not totally.…”
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    Evaluation of Helicobacter pylori infection in patients with common migraine headache
  16. 27476
    “…Until now, the treatment of MG has been based primarily on experience rather than gold-standard evidence from randomized controlled trials. It is hoped that well-organized studies and newer experimental trials will lead to improved treatments.…”
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    Treatment of Myasthenia Gravis Based on Its Immunopathogenesis
  17. 27477
    por Willis, Rudolph E.
    Publicado 2011
    “…Genome wide association studies on cancers with gene analysis of single nucleotide and other mutations in functional proto-oncogenes will, hopefully, identify dysfunctional proto-oncogenes and allow the development of more specific targeted drugs directed against the protein products of these vital oncogenes. …”
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    Human Gene Control by Vital Oncogenes: Revisiting a Theoretical Model and Its Implications for Targeted Cancer Therapy
  18. 27478
    “…The genetics of Polynesian populations has been shaped by island hoping migration events which have possibly favoured thrifty genes. …”
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    Complete Mitochondrial Genome Sequencing Reveals Novel Haplotypes in a Polynesian Population
  19. 27479
    “…BACKGROUND: A pregnant woman is usually young and in good health until she suffers from some acute injury. Her prognosis will hopefully be better if she receives timely intensive care. …”
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    Maternal outcomes in critically ill obstetrics patients: A unique challenge
  20. 27480
    “…Liver-directed gene therapy hopes to achieve long-term correction of the disease while also inducing immune tolerance. …”
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    Transient B Cell Depletion or Improved Transgene Expression by Codon Optimization Promote Tolerance to Factor VIII in Gene Therapy
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