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  1. 27801
    “…We therefore designed a multicenter randomized controlled trial to address these problems and hopefully provide a more conclusive answer to these questions. …”
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    Electro-acupuncture with different current intensities to treat functional constipation: a study protocol for a randomized controlled trial
  2. 27802
    “…With more than 1 billion users having access to mobile broadband Internet and a rapidly growing mobile app market, all stakeholders involved have high hopes that this technology may improve health care. …”
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    mHealth 2.0: Experiences, Possibilities, and Perspectives
  3. 27803
    “…The resulting ranked list of research questions provides a valuable resource for health research investors, researchers and other stakeholders. We are hopeful that this exercise will inform the post-2015 Development Agenda and assist donors, research-policy decision makers and researchers to invest in research that will ultimately make the most significant difference in the lives of mothers and babies.…”
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    Maternal and perinatal health research priorities beyond 2015: an international survey and prioritization exercise
  4. 27804
    “…A multifaceted campaign targeting both physicians and parents of school children was implemented for the first time in order to educate the public and update doctors, aiming to promote judicious use of antibiotics and hopefully decrease its consumption. METHODS: The programme consisted of a public education campaign and academic detailing of primary care physicians in the district of Corinth in Peloponnese. …”
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    Promoting prudent use of antibiotics: the experience from a multifaceted regional campaign in Greece
  5. 27805
    “…CONCLUSION: This alarming result with extensive RM osteomyelitis in the proximal femur of an immunocompromised patient may hopefully warn medical staff to perform early imaging and aggressive surgical supported multimodal treatment in similar cases. …”
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    Clinical challenge: fatal mucormycotic osteomyelitis caused by Rhizopus microsporus despite aggressive multimodal treatment
  6. 27806
    “…CONCLUSIONS: Developing a predictive model including interactions with data that suffers from missingness is easily done by identifying significant interactions and then applying backward elimination to a single data set imputed from the EM algorithm. It is hoped that this idea can be further developed and, by addressing this practical dilemma, there will be increased adoption of multiple imputation in medical research when data suffers from missingness.…”
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    Model development including interactions with multiple imputed data
  7. 27807
    por Lenert, Aleksander, Lenert, Petar
    Publicado 2015
    “…Rituximab for ANCA-associated vasculitis and other clinical trials provided clear evidence that rituximab was not inferior to cyclophosphamide for remission induction, and rituximab appeared even more beneficial in patients with relapsing disease. This raised hopes that other B-cell-targeted therapies directed either against CD19, CD20, CD22, or B-cell survival factors, B-cell activating factor of the tumor necrosis factor family (BAFF) and a proliferation-inducing ligand could also be beneficial for the management of AAV. …”
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    Current and emerging treatment options for ANCA-associated vasculitis: potential role of belimumab and other BAFF/APRIL targeting agents
  8. 27808
    “…However, since the rarity of TAFRO Syndrome, a multicenter registry is strongly desirable for a better understanding of the disease mechanisms, hopefully leading to evidence-based therapeutic choices.…”
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    Successful treatment of a Caucasian case of multifocal Castleman’s disease with TAFRO syndrome with a pathophysiology targeted therapy - a case report
  9. 27809
    “…BACKGROUND: Extensive research efforts have generated genomic, transcriptomic, proteomic, and functional data hoping to elucidate psychiatric pathophysiology. Selected reaction monitoring, a recently developed targeted proteomic mass spectrometric approach, has made it possible to evaluate previous findings and hypotheses with high sensitivity, reproducibility, and quantitative accuracy. …”
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    Targeted Multiplexed Selected Reaction Monitoring Analysis Evaluates Protein Expression Changes of Molecular Risk Factors for Major Psychiatric Disorders
  10. 27810
    “…BACKGROUND: Increased prescribing of inhaled long-acting anti-muscarinic (LAMA) and combined inhaled long-acting β(2)-agonist and corticosteroid (LABA+ICS) drugs for the treatment of chronic obstructive pulmonary disease (COPD) has led to hopes of reduced hospital admissions from this disease. …”
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    Chronic obstructive pulmonary disease hospital admissions and drugs—unexpected positive associations: a retrospective general practice cohort study
  11. 27811
    “…These only possess 0.42 anomalous scattering electrons each at 1.3 Å wavelength, but the 12 that have single predominant positions are easily detectable in the anomalous difference Fourier map. It is hoped that these improvements will lead towards XFEL experimental phase determination and structure determination by sulfur SAD and will generally increase the utility of the method for difficult cases.…”
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    A revised partiality model and post-refinement algorithm for X-ray free-electron laser data
  12. 27812
    “…CONCLUSION: The fascin-1 protein may be a useful prognostic indicator and hopeful new target for NSCLC patients.…”
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    Clinicopathological significance of fascin-1 expression in patients with non-small cell lung cancer
  13. 27813
    “…Today, if a SCA patient has a HLA identical family member, the cellular gene therapy through the transplantation of the allogeneic haemopoietic cell should be performed. Tomorrow, hopefully, the autologous genetically corrected stem cell will break down the wall of the immunological incompatibility.…”
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    Haematopoietic stem cell transplantation in Nigerian sickle cell anaemia children patients
  14. 27814
    “…DISCUSSION: We aim to test the evidence that mulberry leaf extract can reduce blood glucose without a disproportionate increase in blood insulin responses in healthy individuals in a high-quality research study based in the UK. It is hoped that this will lead to further randomised controlled trials and an effective dietary supplement to lower blood glucose concentrations. …”
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    Mulberry extract to modULate Blood glucosE Responses in noRmoglYcaemic adults (MULBERRY): study protocol for a randomised controlled trial
  15. 27815
    “…This mapping technique can potentially identify areas responsible for initiation and persistence of AF and hopefully can individualize both diagnosis and therapy of AF.…”
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    A novel intra-operative, high-resolution atrial mapping approach
  16. 27816
    “…It also provides potential targets for anti-diabetes drug discovery and hopeful clinical applications in human cell therapy.…”
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    Peroxisome proliferator-activated receptorβ/δ activation is essential for modulating p-Foxo1/Foxo1 status in functional insulin-positive cell differentiation
  17. 27817
    “…Now, it has become imperative to understand complex functional biology of CSCs, especially the signaling pathways to design improved treatment strategies to target them. It is hopeful that the SRPs in CSCs offer a promising target to alter their survival strategies and impede their tumorigenic potential. …”
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    Targeting self-renewal pathways in cancer stem cells: clinical implications for cancer therapy
  18. 27818
    “…Upon seeking to understand the configuration and trends in medical education in Brazil, it is hoped that this analysis may contribute to a broader research agenda in the future.…”
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    The privatization of medical education in Brazil: trends and challenges
  19. 27819
    “…OBJECTIVE: We conducted this qualitative study to determine how administrators, clinic staff, and health care providers at practices serving a lower income adult population viewed patient portals in terms of their potential benefit, areas of concern, and hopes for the future. METHODS: We performed in-depth interviews between October 2013 and June 2014 with 20 clinic personnel recruited from health centers in four North Carolina counties. …”
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    Primary Care Providers’ Views of Patient Portals: Interview Study of Perceived Benefits and Consequences
  20. 27820
    “…CONCLUSION: This study established consensus between consumers and professionals in order to produce a set of guidelines on how partners can support each other to prevent depression and anxiety during pregnancy and following childbirth. It is hoped that these guidelines will inform the development of perinatal depression and anxiety prevention efforts. …”
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    Enhancing reciprocal partner support to prevent perinatal depression and anxiety: a Delphi consensus study
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