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28441por Bauër, Pierre, Leemans, Michelle, Audureau, Etienne, Gilbert, Caroline, Armal, Carole, Fromantin, Isabelle“…If validated, the possibility of implementing such a technique in the clinic raises many hopes. This systematic review was performed to determine the evidence and performance of such methods and assess their potential relevance in the clinic. …”
Publicado 2022
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28442“…To our best knowledge, this is the first practical research of combing wearables and machine learning to provide biomechanical feedback in hammer throw. Hopefully, more wearable biomechanical feedback systems integrating artificial intelligence would be developed in the future.…”
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28443por Ferdinandy, Péter, Andreadou, Ioanna, Baxter, Gary F., Bøtker, Hans Erik, Davidson, Sean M., Dobrev, Dobromir, Gersh, Bernard J., Heusch, Gerd, Lecour, Sandrine, Ruiz-Meana, Marisol, Zuurbier, Coert J., Hausenloy, Derek J., Schulz, Rainer“…We emphasize the critical need for taking into account the presence of cardiovascular risk factors as well as comorbidities and their concomitant medications when designing preclinical studies for the identification and validation of cardioprotective drug targets and clinical studies. This will hopefully maximize the success rate of developing rational approaches to effective cardioprotective therapies for the majority of patients with multiple comorbidities. …”
Publicado 2023
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28444“…DISCUSSION: The results form a framework for understanding, designing, developing and evaluating Learning Health Systems at any scale. CONCLUSION: It is hoped that this framework will evolve with use and feedback.…”
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28445por Cammarota, Antonella, Zanuso, Valentina, Manfredi, Giulia Francesca, Murphy, Ravindhi, Pinato, David James, Rimassa, Lorenza“…Still, a considerable number of patients displays primary resistance to ICIs and might benefit from antiangiogenics either alone or in addition to ICIs instead. Hopefully, the ongoing clinical trials will enlighten regarding the most effective treatment pathways. …”
Publicado 2023
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28446por Guedes, Murilo, Bieber, Brian, Dasgupta, Indranil, Vega, Almudena, Nitta, Kosaku, Brunelli, Steven, Hartman, John, Raimann, Jochen G., Robinson, Bruce M., Pisoni, Ronald L.“…Although these results potentially stem from pervasive knowledge gaps in clinical practice, the noteworthy steady increase in serum phosphate in the United States over the past decades may be consequential to patient outcomes, an uncertainty that hopefully will soon be addressed by ongoing clinical trials. …”
Publicado 2022
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28447por He, Xuzhen“…Unsatisfactory performance is found for the CPU platform of other computers (operations are compiled in a non-optimal way) and for high-dimensional complex models for the GPU platform, where each GPU thread in XLA handles 4 (single precision) or 2 (double precision) output elements–hoping to exploit the high-performant instructions that can read/write 4 or 2 floating-point numbers with one instruction. …”
Publicado 2023
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28448Investigation on the regulatory T cells signature and relevant Foxp3/STAT3 axis in esophageal cancerpor Yang, Lin, Zhao, Qijie, Wang, Xing, Pilapong, Chalermchai, Li, Yi, Zou, Jun, Jin, Jing, Rong, Jinfeng“…Tregs regulation is a hopeful strategy to improve the dismal prognosis of Esophageal cancer (EC), while its mechanisms have not yet been fully clarified. …”
Publicado 2022
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28449“…Techniques like CRISPR-Cas genome editing can take several months to achieve a single gene knockout because they rely on aphids going through a cycle of sexual reproduction, and aphids often lack strong, consistent levels of knockdown when fed or injected with molecules that induce an RNA interference (RNAi) response. In the hopes of addressing these challenges, we attempted to adapt a new method called symbiont-mediated RNAi (smRNAi) for use in aphids. smRNAi involves engineering a bacterial symbiont of the insect to continuously supply double-stranded RNA (dsRNA) inside the insect body. …”
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28450“…These data suggest that the current operating room workflow practices, in addition to prior training, should be monitored and hopefully improved for surgeons’ health. Surprisingly, recent studies have suggested the benefits of standing versus sitting on cognitive function. …”
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28451“…Insights into the structural-based CETP-lipoprotein interactions can unravel CETP inhibition machinery, which can hopefully guide the design of more effective CETP inhibitors that combat ASCVD. …”
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28452“…DISCUSSION: In this study, the potential effects of DSP on patients with T2DM will be evaluated for the first time. It is hoped that the results would increase the body of scientific knowledge about DSP supplementation on the cardiometabolic risk factors, oxidative stress, anti-/inflammatory biomarkers, metabolic endotoxaemia, adipokines, hypothalamic–pituitary–adrenal axis biomarkers, immune system, anthropometric indices and mental health in patients with T2DM. …”
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28453“…By introducing routine postoperative assessment and reinforcing the importance of admission assessment, we hoped to allow for objective comparisons to be made about patients cognitive state and thereafter improve delirium identification. …”
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28454por Chen, Qi, Li, Yilan, Bie, Bike, Zhao, Bin, Zhang, Yanxiu, Fang, Shaohong, Li, Shuijie, Zhang, Yao“…CONCLUSIONS: These data highlight a novel and important mechanism for ADAM17 to cause post-MI HF, which will hopefully be a new potential target for early prediction or intervention of post-MI HF. …”
Publicado 2023
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28455“…Ten (40%) indicated that they are excited about gene therapy, 12 (48%) indicated that they are hopeful about gene therapy, one (4%) indicated that they are worried or scared about gene therapy, and one (4%) indicated that they do not have strong feelings about gene therapy. …”
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28456“…DISCUSSION: This study hopes to establish pre-treatment information as a method for reducing DA among the populace. …”
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28457por Machingura, Fortunate, Busza, Joanna, Jamali, Gracious Madimutsa, Makamba, Memory, Mushati, Phillis, Chiyaka, Tarisai, Hargreaves, James, Hensen, Bernadette, Birdthistle, Isolde, Cowan, Frances Mary“…RESULTS: Eligible women were motivated by hopes of escaping poverty, and their longer-term engagement was sustained through exposure to new social networks, including friendships with less vulnerable peers. …”
Publicado 2023
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28458The impact of pandemic mental cognition on cultural values: an empirical study based on social media“…To test and develop the pathogen prevalence hypothesis, we introduced pandemic mental cognition and conducted an empirical study on social media (Chinese Sina Weibo), hoping to explore the psychological reasons behind in cultural value changes in the context of a pandemic. …”
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28459por Takács, Andrea Tímea, Bukva, Mátyás, Bereczki, Csaba, Burián, Katalin, Terhes, Gabriella“…DISCUSSION: Our classification model can be used as a diagnostic decision support tool to distinguish EBC/CMV infection from non EBV/CMV tonsillopharyngitis, thereby significantly reducing the overuse of antibiotics. It is hoped that the model may become a tool worth considering in routine clinical practice and may be developed to differentiate between viral and bacterial infections. …”
Publicado 2023
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28460por Slomp, Caitlin, Morris, Emily, Edwards, Louisa, Hoens, Alison M., Landry, Ginny, Riches, Linda, Ridgway, Lisa, Bryan, Stirling, Austin, Jehannine“…Both groups expressed a need for evidence and numerous considerations for the implementation of PGx testing in BC, including the requirement for conclusive economic analyses, patient and provider education, technological and clinical support, local testing facilities, and measures to ensure equitable access to testing. CONCLUSIONS: While hopeful about the potential for therapeutic benefit from PGx testing, PWLE and P/HCPs see the need for robust evidence of utility, and BC-wide infrastructure and policies to ensure equitable and effective access to PGx testing. …”
Publicado 2022
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