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  1. 28741
    “…We share the difficulties we have encountered, hoping to improve patient care in the future.…”
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    Primary poorly differentiated lacrimal gland adenocarcinoma in left ocular region: A rare case report
  2. 28742
    “…As far as we know, this was the 1st time that milk miRNA target genes had been identified based on such cross-species approach. Hopefully, the introduced strategy should hereby facilitate a variety of cross-species miRNA studies in the future.…”
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    An innovative approach to predict immune-associated genes mutually targeted by cow and human milk microRNAs expression profiles
  3. 28743
    “…OUTCOMES: The primary outcome measures are self-reported craving, inhibitory control and cerebral haemodynamic response to the Stroop test and a substance-related film. It is hoped that the findings from this study will shed more light on the role of exercise in the treatment of substance use disorders, particularly its scope in preventing relapse through reduced craving severity. …”
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    The effects of an acute bout of exercise on neural activity in alcohol and cocaine craving: study protocol for a randomised controlled trial
  4. 28744
    “…Through comparative analyses, we hoped to clarify the evolutionary origin of septin diversity and to suggest which amino acid residues were responsible for subunit binding specificity. …”
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    Diversity of opisthokont septin proteins reveals structural constraints and conserved motifs
  5. 28745
    “…The study utilizes a cutting-edge brain neuroimaging approach to longitudinally trace the effectiveness of both VR-based and conventional training on stroke rehabilitation, which will hopefully describe the effects of the brain mechanisms of the intervention on recovery from stroke. …”
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    Evaluating the effect and mechanism of upper limb motor function recovery induced by immersive virtual-reality-based rehabilitation for subacute stroke subjects: study protocol for a randomized controlled trial
  6. 28746
    “…By developing co-creation-based innovations, these changing needs will hopefully be met. METHODS: A user-driven Living Lab design is used to structurally explore the needs over time of people with dementia (and their informal caregivers) living in the community in the North Brabant region of the Netherlands. …”
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    User-Driven Living Lab for Assistive Technology to Support People With Dementia Living at Home: Protocol for Developing Co-Creation–Based Innovations
  7. 28747
    “…A neuromorphic continuous hand gestures dataset (Neuro ConGD Dataset) was developed with 17 hand gestures classes for the community of the neuromorphic research. Hopefully, FLGR can inspire the study on the event-based highly efficient, high-speed, and high-dynamic-range sequence classification tasks.…”
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    FLGR: Fixed Length Gists Representation Learning for RNN-HMM Hybrid-Based Neuromorphic Continuous Gesture Recognition
  8. 28748
    “…If validated, those surgeons who do not have ORA/VERION can hopefully use this nomogram with greater success.…”
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    Utilizing intraoperative aberrometry and digital eye tracking to develop a novel nomogram for manual astigmatic keratotomy to effectively decrease mild astigmatism during cataract surgery
  9. 28749
    “…Autoantigen-specific methods to prevent and treat Type 1 Diabetes (T1D) carry high hopes to permanently cure this disease, but have largely failed in clinical trials. …”
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    Combining anti-IL-7Rα antibodies with autoantigen-specific immunotherapy enhances non-specific cytokine production but fails to prevent Type 1 Diabetes
  10. 28750
    “…Here, we share the full results of this preliminary (but aborted) assessment of early DAP+CPT therapy versus standard monotherapy in MRSA bacteremia, hoping to encourage a more definitive clinical trial of its potential benefits against this leading cause of infection-associated mortality. …”
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    Clinical Data on Daptomycin plus Ceftaroline versus Standard of Care Monotherapy in the Treatment of Methicillin-Resistant Staphylococcus aureus Bacteremia
  11. 28751
    “…Now, there have not been enough data to explain the mechanism of hyperlipidemia related proteinuria. In this study, we hoped to investigate the changes of Angiopoietin-like protein 3(ANGPTL3) levels in hyperlipidemia patients with different proteinuria levels. …”
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    Angiopoietin-like protein 3 markedly enhanced in the hyperlipidemia related proteinuria
  12. 28752
    “…We discuss these observations with a view to interconnecting the need for compassion for patients with caring for the researchers engaged in the research ecosystem who are aiming to produce much hoped-for advances in medical science. CONCLUSIONS: There is a need for increased awareness of the challenge these studies place on those throughout the team delivering the study. …”
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    Mind the gap? The platform trial as a working environment
  13. 28753
    “…If appropriately validated in long‐term studies with large number of mutation carriers, and hopefully, postmortem or in vivo confirmation of histopathology, RT‐QuIC could contribute to the selection of candidates to receive disease modifying drugs, in particular treatments targeting a‐syn deposition.…”
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    α‐synuclein RT‐QuIC in cerebrospinal fluid of LRRK2‐linked Parkinson's disease
  14. 28754
    “…CONCLUSION: These are unique core-shell nanoparticles synthesized with the presence of multiple functionalities are hoped can be used as a multifunctional nanocarrier with the capability of targeted delivery using an external magnetic field and can also be exploited as hypothermia for cancer cells in addition to the chemotherapy property.…”
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    Synthesis and properties of magnetic nanotheranostics coated with polyethylene glycol/5-fluorouracil/layered double hydroxide
  15. 28755
    “…A proactive approach exploring the benefits and concerns professionals perceive in the adoption of health technology within the HBPC program will hopefully facilitate the optimal integration of telehealth innovations.…”
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    Care Team Perspectives and Acceptance of Telehealth in Scaling a Home-Based Primary Care Program: Qualitative Study
  16. 28756
    “…BACKGROUND: HIV therapy has been moving toward smaller size, once a day regimens in hopes of improved adherence. Surprisingly, few publications characterize HIV patient’s pill preferences. …”
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    2511. Characterization of Patient Pill Preferences from a Prospective Placebo vs. Placebo Ease of Swallowability Study
  17. 28757
    “…CONCLUSION: Predictors of poverty are useful for directing interventions and in the Cuatro Santos area education seems most important to prioritize. Hopefully, the lessons learned can continue to develop the Cuatro Santos communities as well as development in similar poor rural settings around the world.…”
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    Predicting poverty. Data mining approaches to the health and demographic surveillance system in Cuatro Santos, Nicaragua
  18. 28758
    “…Forty-three percent (95% CI 40–46%) of patients hoped that the physical impact of RA will be better understood in future. …”
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    Physical and Emotional Burden of Rheumatoid Arthritis: Data from RA Matters, a Web-Based Survey of Patients and Healthcare Professionals
  19. 28759
    “…Therefore, further studies on how the S100A6 protein facilitates B lymphocyte infiltration and on whether other factors in serum also contribute to this phenomenon are likely to improve our understanding of AE and hopefully to reveal novel therapeutic targets for this emerging treatable neurological disorder.…”
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    S100A6 Promotes B Lymphocyte Penetration Through the Blood–Brain Barrier in Autoimmune Encephalitis
  20. 28760
    “…Further ethical evaluation will hopefully result in specific ethical guidelines for the use of SW-CRTs in both high- and low-resource settings to contribute to responsible functioning of these trials and adequate protection of participants.…”
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    Ethical issues in the design and conduct of stepped-wedge cluster randomized trials in low-resource settings
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