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  1. 29821
    “…On a subsequent visit two months later, the patient stated that he had begun taking numerous supplements in hopes that these would improve his overall medical status. …”
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    Does a Supplement Cocktail a Day Keep the Doctor Away? An Unusual Case of Alcohol Induced Diabetes Mellitus: A Case Report and Review of Literature
  2. 29822
    “…Liver transplantation should certainly be considered earlier in this sub-population. Reasonable hopes come from adjuvant/neoadjuvant trials based on immunotherapies alone or in combination. …”
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    Uni-, Bi- or Trifocal Hepatocellular Carcinoma in Western Patients: Recurrence and Survival after Percutaneous Thermal Ablation
  3. 29823
    “…Our study aims to shed light on the impact of HC on COPD in hopes to improve future management.…”
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    The Impact of Hepatic Cirrhosis on Chronic Obstructive Pulmonary Disease in the United States: A Nationwide Analysis
  4. 29824
    “…We also found that participants formulated overly general queries to broaden the results list hoping to find more specific information. In addition, several participants considered their queries satisfied based on information from the snippets on the result lists alone. …”
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    Web-Based Information Seeking Behaviors of Low-Literacy Hispanic Survivors of Breast Cancer: Observational Pilot Study
  5. 29825
    “…Precision medicine has brought new hopes for patients around the world with the applications of novel technologies for understanding genetics of complex diseases and their translation into clinical services. …”
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    Population Structure of the South West Indian Ocean Islands: Implications for Precision Medicine
  6. 29826
    “…Meanwhile, the low expression of IL-7R, LCK, and HDAC1 detected in the peripheral blood of SSc may indicate the possibility of PAH and hopefully become a biomarker for the early detection of SSc-PAH. …”
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    Altered Cellular Immunity and Differentially Expressed Immune-Related Genes in Patients With Systemic Sclerosis–Associated Pulmonary Arterial Hypertension
  7. 29827
    “…CONCLUSIONS: Immune-related genes will hopefully be potential prognostic biomarkers to predict chemotherapy resistance for CRC. …”
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    Identification of Genes Related to 5-Fluorouracil Based Chemotherapy for Colorectal Cancer
  8. 29828
    “…However, crowdfunding data are largely composed of unstructured text, thereby posing many challenges for researchers hoping to answer questions about specific medical conditions. …”
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    A Disease Identification Algorithm for Medical Crowdfunding Campaigns: Validation Study
  9. 29829
    “…Since its emergence, the COVID-19 pandemic has taken a toll on people’s mental health and affected their hopes for the future. Lifestyle and economic conditions have also been affected and have subsequently impacted people’s sense of confidence in life. …”
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    The Impact of Psychological Capital and Social Capital on Residents’ Mental Health and Happiness During COVID-19: Evidence From China
  10. 29830
    “…These findings will hopefully open new avenues to identify the molecular pathways underlying sex-related nephroprotective effects.…”
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    Sexual dimorphic response to rituximab treatment: A longitudinal observational study in a large cohort of patients with primary membranous nephropathy and persistent nephrotic syndrome
  11. 29831
    “…Top-cited benefits included both aspirational and action-oriented goals, including helping others (94.2%), contributing to society (90.3%), being treated respectfully (86.2%), and hoping for a cure (86.0%). Worry over receiving a placebo (61.3%), rearranging one’s life (41.9%), and experiencing bothersome adverse effects (41.6%) were notable burdens. …”
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    Association of Perceived Benefit or Burden of Research Participation With Participants’ Withdrawal From Cancer Clinical Trials
  12. 29832
    “…BACKGROUND: Legacy—what one leaves behind and how one hopes to be remembered after death—is an unexplored and important dimension of decision-making for people facing serious illnesses. …”
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    Conceptions of Legacy Among People Making Treatment Choices for Serious Illness: Protocol for a Scoping Review
  13. 29833
    “…Once supply was guaranteed and vaccination coverage saturated, the focus shifted from risk groups to anti-vaxxers, the under-aged population, and regions of low coverage. At the same time, hopes to reach herd immunity by vaccination campaigns were put into perspective by the emergence and spread of more contagious and aggressive viral variants. …”
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    A flexible age-dependent, spatially-stratified predictive model for the spread of COVID-19, accounting for multiple viral variants and vaccines
  14. 29834
    “…When diagnosing, treating, and dealing with older adults with diabetes, attention should be paid to screening and assessing frailty in hopes of identifying it early so that appropriate measures of intervention can be taken to avoid or delay the resulting adverse effects.…”
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    Combined effect of diabetes and frailty on mortality among Chinese older adults: A follow-up study
  15. 29835
    “…Most providers liked these changes and hoped they would continue after the pandemic subsides. …”
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    Provider perspectives on service delivery modifications to maintain access to HIV pre‐exposure prophylaxis during the COVID‐19 pandemic: qualitative results from a PrEP implementation project in Kenya
  16. 29836
    “…CONCLUSION: Our results suggest that the early combination of PD-1 inhibitors has manageable toxicity and hopeful efficacy in patients with uHCC.…”
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    Clinical outcomes of lenvatinib plus transarterial chemoembolization with or without programmed death receptor-1 inhibitors in unresectable hepatocellular carcinoma
  17. 29837
    “…Based on our findings, we are designing an investigator-initiated phase II clinical trial on the efficacy and safety of irbesartan plus a standard gemcitabine/nab-paclitaxel regimen in the treatment of patients with advanced III/IV staged PDAC and are hopeful that we will observe patient benefits. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13046-023-02671-8.…”
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    Irbesartan overcomes gemcitabine resistance in pancreatic cancer by suppressing stemness and iron metabolism via inhibition of the Hippo/YAP1/c-Jun axis
  18. 29838
    “…Therefore, improving the survival and viability of MSCs will provide a hopeful therapeutic efficacy for ICH. Notably, the biomedical applications of coordination chemistry-mediated metal-quercetin complex have been verified positively and studied extensively, including growth-promoting and imaging probes. …”
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    Mesenchymal stem cells transplantation combined with IronQ attenuates ICH-induced inflammation response via Mincle/syk signaling pathway
  19. 29839
    “…The purpose of this study was to shed light on the different expression of lipidome between pneumoconiosis and healthy, hoping to bring new ideas for the diagnosis and treatment of pneumoconiosis. …”
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    Novel lipidomes profile and clinical phenotype identified in pneumoconiosis patients
  20. 29840
    “…As the first cultural adaption of a digital SI intervention for Syrian asylum seekers and refugees, this study will hopefully encourage further development of culturally sensitive interventions for the largest refugee population in the United Kingdom and the world. …”
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    Culturally Adapting a Digital Intervention to Reduce Suicidal Ideation for Syrian Asylum Seekers and Refugees in the United Kingdom: Protocol for a Qualitative Study
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