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  1. 6181
    “…A clear consensus on whether HFI presents a clinical risk has not been reached. We hope that this report on a unique manifestation of HFI will help clinicians in evaluating patients with this condition.…”
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    A Case Report of Hyperostosis Frontalis Interna
  2. 6182
    por LEE, Karla A., NATHAN, Paul
    Publicado 2020
    “…This decade has brought significantly improved out-comes for patients with advanced melanoma with immunotherapies and targeted treatments offering utility in a variety of settings. In 2020, we can hope for durable long-term responses, and complete remission in a subset of patients with metastatic disease. …”
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    Cutaneous Melanoma – A Review of Systemic Therapies
  3. 6183
    por Drake, Joshua C., Yan, Zhen
    Publicado 2019
    “…We contend that this is the only hope that we have to face the challenges of population growth and aging, as well as the upward trend in non-communicable disease prevalence.…”
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    Targeting healthspan to optimally combat non-communicable disease in an aging world
  4. 6184
    “…Here, we review genomic variation-mediating fluconazole resistance in the yeast Candida, with the hope of highlighting the functional consequences of genomic variations for the antifungal resistance.…”
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    Genomic Variation-Mediating Fluconazole Resistance in Yeast
  5. 6185
    “…The therapeutic potential of BDNF treatment is also discussed, in the hope of discovering new avenues for the treatment of neurodegenerative diseases.…”
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    Recent Advances on the Role of Brain-Derived Neurotrophic Factor (BDNF) in Neurodegenerative Diseases
  6. 6186
    “…In this study, we propose four new species of Harringtonia associated with beetles from Belize and Florida (USA). We hope to contribute towards a more robust and inclusive phylogenetic framework for future studies on these beetle-fungi relationships and their potential impact in crops and forests worldwide.…”
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    Four New Species of Harringtonia: Unravelling the Laurel Wilt Fungal Genus
  7. 6187
    “…In this Perspective, we highlight select systems in the hope of demonstrating the breadth of ArM design strategies and applications and emphasize how these systems address problems that are otherwise difficult to do so with strictly biochemical or synthetic approaches.…”
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    Artificial Metalloproteins: At the Interface between Biology and Chemistry
  8. 6188
    por Miyaki, Candace, Lynch, Launa M
    Publicado 2022
    “…Given the poor prognosis of pancreatic cancer despite treatment, medication prophylaxis prevention should be considered. In this review, we hope to encourage future case-control or prospective studies on common medications that have shown great potential in delaying pancreatic cancer development.…”
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    An Update on Common Pharmaceuticals in the Prevention of Pancreatic Cancer
  9. 6189
    “…Here, our editorial members have summarized twelve topics from published work and discussed current topics in depth. We hope you enjoy our special feature, “Update on Hypertension Research in 2021”.…”
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    Update on Hypertension Research in 2021
  10. 6190
    “…Although counterintuitive, even in the presence of craniosynostosis, patients with this finding can also have intracranial CSF fluid collections such as the MCM reported here. We hope this report will enhance our understanding of some similar cases that are equivocal regarding raised ICP.…”
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    Bilateral Coronal Synostosis and Mega Cisterna Magna: A Case Report
  11. 6191
    “…The gracilis muscle as a donor flap allowed for the protection and support of the testes and suspensory tissue while achieving an aesthetically pleasing result that resembled the normal scrotum. We hope providers will consider this reconstructive method in future patients who present with similar extensive effacement of the scrotal tissue.…”
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    Reconstruction of the Scrotum With Bilateral Gracilis Muscle Rotational Flaps in a Patient With Acute Myeloid Leukemia Complicated by Fournier’s Gangrene
  12. 6192
    “…Further clinical trials with other aspirin or NSAID biomarkers or clinical trials with other potential chemopreventive agents offer hope to those who are at increased risk for melanomas. …”
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    The Challenge of Melanoma Chemoprevention
  13. 6193
    “…We propose a rigorous device characterisation procedure that will allow for standardised evaluation of novel devices, which we hope will accelerate research and investment in this area.…”
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    Best practices in the measurement of circularly polarised photodetectors
  14. 6194
    “…The review also discusses use of peptides as anti-cancer vaccines and their efficiency as drug-delivery tools. We hope this work will give the reader a clear idea of the mechanisms of peptide-based anti-cancer therapeutics and encourage the development of superior drugs in the future.…”
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    Peptide therapeutics in the management of metastatic cancers
  15. 6195
    por Su, Dan, Kosciuk, Tatsiana, Lin, Hening
    Publicado 2022
    “…Meinnel recently commented on our finding, and we hope this Reply helps to clarify some of the important points we aimed to make in the original article.…”
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    Reply to Comment on “Binding Affinity Determines Substrate Specificity and Enables Discovery of substrates for N-Myristoyltransferases”
  16. 6196
    por Yan, Yu, Wang, Yiming, Lei, Yiming
    Publicado 2022
    “…In the model of this article, weited theory, multiclassification problem and online learning have all become the direct inference, and we have applied the new model to the UCI data set. We hope that in the future, this model will be useful in real-world problems such as stock forecasting, which require nonlinear hi-speed algorithms.…”
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    Micro Learning Support Vector Machine for Pattern Classification: A High-Speed Algorithm
  17. 6197
    “…The inflammatory component of diabetic kidney disease is of great interest and is an active research field, with the hope to find potential innovative therapeutic targets.…”
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    Molecular Mechanisms of Diabetic Kidney Disease
  18. 6198
    “…In the following three different cases, we demonstrate the role and benefit of treatment with neoadjuvant immune checkpoint inhibitors in patients that have an extensive tumor burden at diagnosis, making them ineligible for operative treatment. Our hope is that these cases serve as a foreshadowing of the potential neoadjuvant treatments have in this oncological setting.…”
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    Neoadjuvant Immunotherapy in the Treatment of Renal Cell Carcinoma: A Case Series
  19. 6199
    “…Here we present a rare case of severe anemia found in a patient with chronic lice colonization. We hope our findings will broaden the differential for acute anemias and raise awareness of lice infection as a possible cause of acute anemia.…”
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    A Rare Case of Anemia Secondary to Lice Infestation
  20. 6200
    por Dalal, Fazal, Dalal, Hussain, Baltz, Brad
    Publicado 2022
    “…While both side effects of pembrolizumab are well known, the delayed presentation of symptoms is of particular interest in our case report. We hope to inform the clinical community on the pharmacokinetics of pembrolizumab causing the delayed onset of symptoms.…”
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    Pembrolizumab-Induced Myocarditis and Delayed Acute Inflammatory Demyelinating Polyradiculoneuropathy
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