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6561por Karoutzou, Olga, Kwak, Seung-Hwa, Lee, So-Deok, Martínez-Falguera, Daina, Sureda, Francesc X., Vázquez, Santiago, Kim, Yong-Chul, Barniol-Xicota, Marta“…Multi-target-directed ligands (MTDLs) offer new hope for the treatment of multifactorial complex diseases such as Alzheimer’s Disease (AD). …”
Publicado 2018
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6562por da Silva, Lucia Regina Cangussu“…In this paper, we review the current literature to understand ZIKV trafficking from the bloodstream to the human male reproductive tract and viral interactions with host cells in interstitial spaces, tubule walls, annexed glands and semen. We hope to highlight gaps to be filled by future research and potential routes for vaccine and antiviral development.…”
Publicado 2018
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6563por Ziegenhain, Christoph, Vieth, Beate, Parekh, Swati, Hellmann, Ines, Enard, Wolfgang“…We also review and compare the essential methods to process scRNA-seq data from mapping, filtering, normalization and batch corrections to basic differential expression analysis. We hope that this helps to choose appropriate experimental and computational methods for the research question at hand.…”
Publicado 2018
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6564“…We also report the reasons participants cited for not reading more of the textbook. We hope this analysis will allow educators to have a better understanding of the level of pre-lecture reading that is occurring in a traditional lecture-style course and the impacts of pre-lecture reading on student success.…”
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6565“…We also extend the conversation to why there needs to be a fundamental shift away from demand-side interventions to supply-side interventions. In doing so, we hope to offer a more equitable perspective to health and development.…”
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6566“…This paper reviews the literature on social neuroscience studies using macaques in the hope of encouraging as many researchers as possible to participate in this field of research and thereby accelerate the system-level understanding of social cognition and behavior. …”
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6567por Gruber-Bzura, Beata M.“…Because vitamin D could be acknowledged as a “seasonal stimulus”, as defined by R. Edgar Hope-Simpson, it would be crucial to prove it from a potential easy and cheap prophylaxis or therapy support perspective as far as influenza infections are concerned. …”
Publicado 2018
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6568“…We found that motions such as trochoid-like motion and circular motion emerged depending on the magnitude or symmetricity of fluctuations in the bubble-propulsion process. We hope that those results will help in the construction and application of sophisticated bubble-propelled micromotors in the future.…”
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6569“…Although Pt(IV) complexes that conjugated with bioactive ligands show satisfactory anticancer effects, none has been approved for clinical use. Therefore, we hope that this review will contribute to further study and development of Pt(IV) complexes conjugated with bioactive and other ligands.…”
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6570“…It was also found that the length of hydrogen bond might contribute dominantly the interaction between two enantiomers and CSP. We hope our study could provide a fresh perspective to explore the stereochemistry and chiral recognition mechanism of chiral drugs.…”
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6571“…Modern continent urinary diversion techniques offer new perspectives and hope for such complex population.…”
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6572“…Naturally occurring small molecule compounds have long been in the spotlight of pancreatic cancer research as potential therapeutics to prevent cancer progression and sensitize chemoresistant tumors. The hope is that terminal pancreatic cancer patients receiving aggressive chemotherapy can benefit from an increase in treatment efficacy without adding further toxicity by way of utilizing natural compounds. …”
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6573“…We prepared these critical points in a letter to the editor and hope to be an interest of you.…”
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6574“…In this article, the proposed mechanisms of action of artemisinins are reviewed in light of medicinal chemistry findings characterized by efficacy-structure studies, with the hope of gaining more insight into how these potent drugs work.…”
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6575“…Steady and solid progress in stem cell research in both basic and preclinical settings should support the hope for development of stem cell-based cell therapies for neurological diseases.…”
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6576“…Furthermore, a phase diagram for the wrapping of NPs has been constructed, which clarifies the interrelated effects of the size and the ligand density of NPs. We hope that this work can provide some help in understanding the physical mechanism of the wrapping of NPs.…”
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6577por Lopes, Lindsey E., Waldis, Sarah J., Terrell, Stephanie M., Lindgren, Kristin A., Charkoudian, Louise K.“…By discussing the steps others can take to cultivate reciprocal outreach within their local communities, we hope to lower the barrier for widespread adoption of similar approaches and ultimately to decrease the gap between formally trained scientists and the general public.…”
Publicado 2018
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6578“…Finally, we present the protocol of a study concerning teenagers’ morality in everyday life, discussing our epistemological choices as an example of a pragmatic approach in empirical ethics. We hope that this article conveys that even though the scope of neuroethics is broad, it is important not to move too far from the real life encounters that give rise to moral questions in the first place.…”
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6579“…Appropriate application of the statistical values is discussed. We hope that this article will facilitate more active use of the CIT outside Japan.…”
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6580“…As well, the glass transition temperature of the composite material increased by 25 °C. It is hope that this work will inform ongoing efforts to exploit more efficient methods to overcome the poor natural fiber/polymer adhesion in the interface region.…”
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