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21“…Both serve patients through a spoke-and-hub network, have participated in multiple randomized endovascular stroke trials, and have successfully used these remote options for enrollment. …”
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22“…A gene signature based on the DEmRNAs in hub network was also generated for further evaluation. …”
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23por Jing, Rixing, Huo, Yanxi, Si, Juanning, Li, Huiyu, Yu, Mingxin, Lin, Xiao, Liu, Guozhong, Li, Peng“…Compared with HC, FEDN MDD patients exhibited altered spatio-temporal functional states of the default mode network (DMN), the salience network, a hub network (centered on the dorsolateral prefrontal cortex), and a relatively complex coupling network (visual, DMN, motor-somatosensory and subcortical networks). …”
Publicado 2022
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24por Leppin, Aaron L., Okamoto, Janet M., Organick, Paige W., Thota, Anjali D., Barrera-Flores, Francisco J., Wieland, Mark L., McCoy, Rozalina G., Bonacci, Robert P., Montori, Victor M.“…Methods: Through formative research, we defined and conceptualized key characteristics of a bridging hub network and identified a set of candidate measures—(1) network membership, (2) network interaction, (3) role and reach of the bridging hub, and (4) network collaboration—to evaluate its implementation within a pre-determined geographic region of Southeast Minnesota, USA. …”
Publicado 2018
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25por Kim, Sarah M., Peña, Matthew I., Moll, Mark, Bennett, George N., Kavraki, Lydia E.“…To investigate the efficacy of this method, we created a table describing a network of common hub metabolites and how they are biochemically connected and only offloaded searches to and from this hub network onto an interactive webserver capable of visualizing the resulting pathways. …”
Publicado 2020
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26“…Through the construction of the OP-related miRNA–mRNA regulatory network, a hub network that may play a prominent role in the formation of OP was documented. …”
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27por Saviola, Francesca, Zigiotto, Luca, Novello, Lisa, Zacà, Domenico, Annicchiarico, Luciano, Corsini, Francesco, Rozzanigo, Umberto, Papagno, Costanza, Jovicich, Jorge, Sarubbo, Silvio“…Regardless of tumor side, only lower-grade gliomas showed longitudinal FC increases relative to high-grade tumors within a precise hub network, the DMN. The neurocognitive profile was longitudinally associated with spatial features of the connectome, mainly within the DMN. …”
Publicado 2022
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28por Wei, Lei, Zhang, Yao, Zhai, Wensheng, Wang, Huaning, Zhang, Junchao, Jin, Haojie, Feng, Jianfei, Qin, Qin, Xu, Hao, Li, Baojuan, Liu, Jian“…RESULTS: For both groups, SMN acted like a hub network which demonstrated dense effective connectivity with other large-scale brain network. …”
Publicado 2022
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29por Udyavar, Akshata R, Hoeksema, Megan D, Clark, Jonathan E, Zou, Yong, Tang, Zuojian, Li, Zhiguo, Li, Ming, Chen, Heidi, Statnikov, Alexander, Shyr, Yu, Liebler, Daniel C, Field, John, Eisenberg, Rosana, Estrada, Lourdes, Massion, Pierre P, Quaranta, Vito“…The classifier, termed SCLC-specific hub network (SSHN), robustly separates SCLC from other lung cancer types across multiple datasets and multiple platforms, including RNA-seq and shotgun proteomics. …”
Publicado 2013
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30“…The top 6 hub genes consisted of downregulated FOS, IGF2, FOXO1 and NTF3, upregulated IGF1R, and insignificantly downregulated HGF in ICC tissues, when compared to that of normal adjacent tissues, followed by the successful construction of lncRNA-miR-hub network consisting of 86 ceRNA modules. MME-AS1 and hsa-miR-182 were associated with overall survival in ICC patients. …”
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31por Nie, Fujiao, Yan, Jiazhao, Ling, Yanjun, Liu, Zhengrong, Fu, Chaojun, Li, Xiang, Qin, Yuhui“…Both PARP1 and GAPDH were found involved in the hub network of protein-protein interaction (PPI) of potential targets and were found to take part in many bioprocesses, including responding to the regulation of reactive oxygen species (ROS) metabolic process, apoptotic signaling pathway, and response to oxygen levels through enrichment analysis. …”
Publicado 2021
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32“…For small p and q = 1, the model produces super-hub networks, and we prove that for p = 0 and q = 1, the proportion of non-hubs tends to 1 as the network grows. …”
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33“…Virtual lesion analyses accentuated these findings, demonstrating that attentional and executive hub networks are points of critical vulnerability in the human causal connectome. …”
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34por Shi, Xin, Cao, Yaochen, Zhang, Xiaobin, Gu, Chang, Liang, Feng, Xue, Jieyuan, Ni, Han-Wen, Wang, Zi, Li, Yi, Wang, Xia, Cai, Zhaohua, Hocher, Berthold, Shen, Ling-Hong, He, Ben“…To lucubrate the potential functions, we performed a ClueGO analysis of these hub networks. Results: In this study, we identified that the levels of FTO, YTHDF3, ZC3H13, and WTAP were dramatically differently expressed in MI tissues compared with controls. …”
Publicado 2021
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35por Black, Robert D., Bell, Ryan P., Riska, Kristal M., Spankovich, Christopher, Peters, Richard W., Lascola, Christopher D., Whitlow, Christopher T.“…The activation of hub networks identified by ICA is consistent with the concept of sensory neuromodulation, which posits that a modulatory signal introduced to a sensory organ is able to traverse the regions innervated (directly and indirectly) by that organ, while being transformed so as to be “matched” to regional neuronal dynamics. …”
Publicado 2021
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36“…Topological centrality (degree) analysis was performed for the Objective network to explore the hub genes and hub networks. Subsequent to isolating the intersections between the Pathway and Objective networks, randomization tests were conducted to identify the differential pathways. …”
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37“…DynaMod allows the inspection of a wide variety of functional modules such as the biological pathways, transcriptional factor–target gene groups, microRNA–target gene groups, protein complexes and hub networks involved in protein interactome. The statistical significance of dynamic functional modularity is scored based on Z-statistics from the average of mutual information (MI) changes of involved gene pairs under different conditions. …”
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38por Zhao, Ming, Qin, Jian, Yin, Hanqi, Tan, Yixin, Liao, Wei, Liu, Qian, Luo, Shuangyan, He, Min, Liang, Gongping, Shi, Yajing, Zhang, Qing, Cai, Wenjun, Yin, Guangliang, Zhou, Yin, Wang, Jing, Li, Mengying, Huang, Yi, Liu, Aiyun, Wu, Haijing, Zhang, Zhiyong, Lu, Qianjin“…A total 659 genes showed significantly expression changes across NB, MA and LL individuals, in which we identified four age-related co-expression modules with three hub networks of co-expressed genes and non-coding RNAs. …”
Publicado 2016
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39por Li, Qing-Run, Wang, Zi-Ming, Wewer Albrechtsen, Nicolai J., Wang, Dan-Dan, Su, Zhi-Duan, Gao, Xian-Fu, Wu, Qing-Qing, Zhang, Hui-Ping, Zhu, Li, Li, Rong-Xia, Jacobsen, SivHesse, Jørgensen, Nils Bruun, Dirksen, Carsten, Bojsen-Møller, Kirstine N., Petersen, Jacob S., Madsbad, Sten, Clausen, Trine R., Diderichsen, Børge, Chen, Luo-Nan, Holst, Jens J., Zeng, Rong, Wu, Jia-Rui“…Particularly, the time-dependent changes of the molecular hub-networks differed between DO and NO groups after RYGB. …”
Publicado 2018
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40por Xu, Wenyi, Ru, Ping, Gu, Zhuorong, Zhang, Ruoxi, Pang, Xixia, Huang, Yi, Liu, Zhou, Liu, Ming“…Protein-protein interaction (PPI) network analysis identified several hub networks and key genes, including MAPK8, CCNF, CDC23, ABL1, NF1, UBE2E3, CD44, and PIK3R1. …”
Publicado 2020
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