“…RESULTS: We observed that CXCR4 forms heteromers with LPA(1) in recombinant HEK293A cells and the human breast cancer cell line MDA-MB-231. Coexpression of LPA(1) with CXCR4 reduced CXCL12-mediated cAMP inhibition, ERK activation, Gα(i/o) activation, and β-arrestin recruitment, while CXCL12 binding to CXCR4 remained unaffected. …”
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“…Screening for high-risk human papillomavirus (hrHPV) and point-of-care (POC) testing are scientific advances used globally to prevent cervical cancer. …”
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“…DESIGN, SETTING, AND PARTICIPANTS: The GO30103 open-label, first-in-human phase 1a/1b dose-escalation and dose-expansion nonrandomized controlled trial was conducted at 13 sites in 6 countries (Australia, Canada, France, Korea, Spain, and the US). …”
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“…IMPORTANCE: Individuals with a mental disorder experience substantial health disparity and are less likely to participate in cervical screening and human papillomavirus vaccination. Additionally, this population may benefit less from tertiary cancer prevention. …”
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“…Recent evidence demonstrated that the human leukocyte antigen (HLA) polymorphisms play important roles in the development of drug-related SCARs. …”
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“…The variety and complexity of human conditions make it impossible to always reach the most appropriate diagnosis or to predict with certainty a particular response to treatment. …”
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“…BACKGROUND: Metabolic syndrome (MetS), a worldwide public health problem, affects human health and quality of life in a dramatic manner. …”
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“…BACKGROUND: SGN-B7H4V is a novel investigational vedotin antibody–drug conjugate (ADC) comprising a B7-H4-directed human monoclonal antibody conjugated to the cytotoxic payload monomethyl auristatin E (MMAE) via a protease-cleavable maleimidocaproyl valine citrulline (mc-vc) linker. …”
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“…Method We used Aip(lox/lox) (Con) and rGHp-Cre(tg/+); Aip(lox/lox) mice (Acro), which was previously established to model the phenotype of human acromegaly. To generate orthotopic xenograft model, we used C57BL/6 female mouse derived breast cancer cell line Py230 cells. …”
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“…Introduction: Alpelisib is a p110a subunit phosphatidylinositol-3kinase inhibitor (PI3K) approved for treating hormone receptor-positive, human epidermal growth factor receptor 2-negative, PIK3CA mutated, advanced or metastatic breast cancer. …”
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“…Although mice successfully recover within a week, we observe long-lasting anxiety-like behaviors in C57BL/6J mice of both sexes up to 3 weeks post-CLP as shown by decreased time spent in the open areas of an elevated zero maze compared to SHAM mice (52.24±24.60 vs. 74.32±20.25 seconds; p<0.05; n=12 CLP, n=18 SHAM), reminiscent of the symptoms seen in human sepsis survivors. To elucidate the mechanisms underlying anxiety-like behavior in CLP survivors, we performed bulk RNA-sequencing in hippocampal tissues 3 weeks after SHAM or CLP surgeries. …”
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“…ArrayCGH analysis was performed on DNAs isolated from fresh frozen tumor tissue using the Human Genome CGH Microarray 244K and 180K oligonucleotide arrays. …”
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“…Garetosmab is an investigational fully human monoclonal antibody against activin-A that prevents formation of new heterotopic ossification lesions. …”
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“…Endocr Pract. 2010;16(5):778-784.2.Grunberger G, et al. Human regular U-500 insulin via continuous subcutaneous insulin infusion versus multiple daily injections in adults with type 2 diabetes: The VIVID study. …”
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“…As part of this ongoing project we intend to categorize degrees of metabolic and reproductive abnormalities of the PCOS models and relate to human PCOS phenotypes, and, along with integration with –omics analysis of diverse key tissues, survey the genetics of inter-tissue signaling as a result of PCOS.In summary, we present a framework to study genetic differences in the context of PCOS and here we showed that the effect of a PCOS-model on key reproductive and metabolic traits is heavily modulated by the genetic background, thus highlighting future directions for the assessment of gene by PCOS interactions. …”
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“…We have identified a specific temporal window during renal development in which the mineralocorticoid signaling pathway is ineffective due to downregulation of MR expression, explaining physiological sodium wasting observed in human newborns during first days of life. However, underlying molecular mechanisms controlling MR expression remain unknown. …”
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“…Bound transcription factors were quantified using mass spectrometry (SimulTOF 300). Fixed human CD adenomas (n=5) were sectioned and stained using multiplexed immunohistochemistry (mIHC). …”
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“…In our review of literature, we could not find any similar reports in human beings and would like to educate the endocrine community of this possible association. …”
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“…Group A was treated with gonadotropins [urofollitropin 150 IU three times a week and human chorionic gonadotropin (hCG) 2000 IU twice a week], Group B with liraglutide (3 mg daily), and Group C with transdermal testosterone (60 mg daily). …”
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“…With the aim to selectively drive NIS-transgene expression in the context of DTC, MSCs were stably transfected with a NIS-expressing plasmid controlled by the human IL-6-promoter (IL-6-NIS-MSCs). This approach may represent a new tumor-target gene therapy for RAI-refractory DTC. …”
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