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  1. 691841
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    Kisspeptin and neurokinin B interactions in modulating gonadotropin secretion in women with polycystic ovary syndrome
  2. 691842
    “…To further enhance adjuvant efficacy, we performed a structure-activity relationship study for the TLR4 ligand, N-cyclohexyl-2-((5-methyl-4-oxo-3-phenyl-4,5-dihydro-3H-pyrimido[5,4-b]indol-2-yl)thio)acetamide (C(25)H(26)N(4)O(2)S; 1Z105), and identified the 8-(furan-2-yl) substituted pyrimido[5,4-b]indole analog (C(29)H(28)N(4)O(3)S; 2B182C) as a derivative with higher potency in activating both human and mouse TLR4-NF-κB reporter cells and primary cells. …”
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    A Novel Synthetic Dual Agonistic Liposomal TLR4/7 Adjuvant Promotes Broad Immune Responses in an Influenza Vaccine With Minimal Reactogenicity
  3. 691843
    “…BACKGROUND: Artificial intelligence–based assistive diagnostic systems imitate the deductive reasoning process of a human physician in biomedical disease diagnosis and treatment decision making. …”
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    Artificial Intelligence–Based Traditional Chinese Medicine Assistive Diagnostic System: Validation Study
  4. 691844
    “…While patients embraced the convenience and patient-centeredness of the model, preference for traditional adherence counseling and need for greater human resources influenced intervention appropriateness and feasibility from the provider perspective. …”
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    Participation in adherence clubs and on-time drug pickup among HIV-infected adults in Zambia: A matched-pair cluster randomized trial
  5. 691845
    “…BACKGROUND: Some multifunctional cellular proteins, as the monocyte chemotactic protein-induced protein 1 (ZC3H12A/MCPIP1) and the cyclin-dependent kinase inhibitor CDKN1A/p21, are able to modulate the cellular susceptibility to the human immunodeficiency virus type 1 (HIV-1). Several studies showed that CDKN1A/p21 is expressed at high levels ex vivo in cells from individuals who naturally control HIV-1 replication (HIC) and a recent study supports a coordinate regulation of ZC3H12A/MCPIP1 and CDKN1A/p21 transcripts in a model of renal carcinoma cells. …”
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    Increased expression of CDKN1A/p21 in HIV-1 controllers is correlated with upregulation of ZC3H12A/MCPIP1
  6. 691846
    “…Data obtained can be used for more confident identification of pollution sources and pollutants’ migration routes and more effective conservation and remediation of human-affected soils at the Caspian Sea coast.…”
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    Data on the soilscape and vegetation properties at the key site in the NW Caspian sea coast, Russia
  7. 691847
    “…The strongest susceptibility human leukocyte antigen (HLA) class II alleles for MS are distinct between races (DRB1*15:01 for Caucasians and DRB1*04:05 and DRB1*15:01 for Japanese); therefore, we investigated whether HLA class II alleles modulate anti-JCV antibody serostatus in Japanese MS patients with and without fingolimod. …”
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    Two susceptible HLA-DRB1 alleles for multiple sclerosis differentially regulate anti-JC virus antibody serostatus along with fingolimod
  8. 691848
    Publicado 2017
    “…OBJECTIVE: To observe the efficacy and safety between Pegfilgrastim (PEG-rhG-CSF) and Recombinant human granulocyte colony stimulating factor (rhG-CSF) in hematological malignancy after allogeneic hematopoietic stem cell transplantation (allo-HSCT). …”
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    聚乙二醇化G-CSF与重组人G-CSF促进恶性血液病异基因造血干细胞移植后造血恢复的对比研究
  9. 691849
    “…INTERVENTION(S): A fixed human menopausal gonadotropin (hMG) antagonist protocol was used for all patients. …”
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    Combinational approach of retrospective clinical evidence and transcriptomics highlight AMH superiority to FSH, as successful ICSI outcome predictor
  10. 691850
    “…The objective of the study is to evaluate whether chronic AVA supplementation could attenuate peripheral inflammatory and immunological markers in human subjects in response to an acute bout of downhill running (DR). …”
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    Avenanthramide supplementation reduces eccentric exercise-induced inflammation in young men and women
  11. 691851
    “…CONCLUSION: The findings from the first-in-human study support further evaluation of TRV250, a G-protein selective DOR agonist, in the treatment of acute migraine.…”
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    A Phase I, Randomized, Single‑Blind, Placebo‑Controlled, Single Ascending Dose Study of the Safety, Tolerability, and Pharmacokinetics of Subcutaneous and Oral TRV250, a G Protein-Selective Delta Receptor Agonist, in Healthy Subjects
  12. 691852
    “…METHODS: Six non-paired, fresh frozen human cadaveric knees (n = 6) were utilized for this study. …”
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    The Anatomy and Length Changes of the Lateral Patellofemoral Ligament and Lateral Patellotibial Ligament
  13. 691853
    “…Given the high incidence of pediatric meniscal injuries and reliance on landmarks to guide arthroscopic meniscus repair, surprisingly few human pediatric cadaveric studies are reported in the current literature. …”
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    Growth of The Pediatric Knee Meniscus: A Cadaveric Study
  14. 691854
    “…OBJECTIVES: Human immunodeficiency virus (HIV) remains a major challenge to global health. …”
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    Rotator cuff repair in HIV-infected patients: an analysis of postoperative complications
  15. 691855
    “…OBJECTIVES: The purpose of this study is to investigate the therapeutic potential of SS-31, a target to improve mitochondria function for the treatment of tendinopathy using human tenocytes. METHODS: After IRB approval (IRB# 2018-0490), samples of non-injured hamstring tendon were obtained from 9 patients at the time of surgery (Fig 1 and Table 1). …”
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    Evaluation of SS-31 as a Potential Therapeutic Target in the Treatment of Tendinopathy
  16. 691856
    “…Excessive fibrosis is associated with adverse clinical outcomes, but longitudinal human data regarding changes in left ventricular remodelling and fibrosis over time are sparse because of the slow progression, thereby making longitudinal studies challenging. …”
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    Progression and regression of left ventricular hypertrophy and myocardial fibrosis in a mouse model of hypertension and concomitant cardiomyopathy
  17. 691857
    “…Although various PET probes targeting TSPO have been developed, a highly selective probe for detecting TSPO is still needed because single nucleotide polymorphisms in the human TSPO gene greatly affect the binding affinity of TSPO ligands. …”
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    [(18)F]CB251 PET/MR imaging probe targeting translocator protein (TSPO) independent of its Polymorphism in a Neuroinflammation Model
  18. 691858
    “…CHO-PS70 cells, stably over-expressing wild-type human APP, served to evaluate whether Aβ42 peptide treatment results in altered APP glycosylation. …”
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    Amyloid precursor protein glycosylation is altered in the brain of patients with Alzheimer’s disease
  19. 691859
    “…BACKGROUND: Utilization of antiretroviral therapy (ART) is crucial for better health outcomes among people living with the human immunodeficiency virus (PLHIV). Nearly 30% of the 1.6 million PLHIV in Tanzania are not on treatment. …”
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    ART use and associated factors among HIV positive caregivers of orphans and vulnerable children in Tanzania
  20. 691860
    “…Personalized coaching components for Stay Strong+Coaching comprised of automated in-app motivational messages (3 per week), telephone-based human health coaching (up to 3 calls), and personalized weekly goal setting. …”
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    Effect of Adding Telephone-Based Brief Coaching to an mHealth App (Stay Strong) for Promoting Physical Activity Among Veterans: Randomized Controlled Trial
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