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  1. 691981
    “…BACKGROUND: Access to essential medicines is a universal human right and availability and affordability are the preconditions for it. …”
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    Availability, pricing and affordability of essential medicines in Eastern Ethiopia: a comprehensive analysis using WHO/HAI methodology
  2. 691982
    por Pagnamenta, Alistair T, Kaiyrzhanov, Rauan, Zou, Yaqun, Da'as, Sahar I, Maroofian, Reza, Donkervoort, Sandra, Dominik, Natalia, Lauffer, Marlen, Ferla, Matteo P, Orioli, Andrea, Giess, Adam, Tucci, Arianna, Beetz, Christian, Sedghi, Maryam, Ansari, Behnaz, Barresi, Rita, Basiri, Keivan, Cortese, Andrea, Elgar, Greg, Fernandez-Garcia, Miguel A, Yip, Janice, Foley, A Reghan, Gutowski, Nicholas, Jungbluth, Heinz, Lassche, Saskia, Lavin, Tim, Marcelis, Carlo, Marks, Peter, Marini-Bettolo, Chiara, Medne, Livija, Moslemi, Ali-Reza, Sarkozy, Anna, Reilly, Mary M, Muntoni, Francesco, Millan, Francisca, Muraresku, Colleen C, Need, Anna C, Nemeth, Andrea H, Neuhaus, Sarah B, Norwood, Fiona, O'Donnell, Marie, O’Driscoll, Mary, Rankin, Julia, Yum, Sabrina W, Zolkipli-Cunningham, Zarazuela, Brusius, Isabell, Wunderlich, Gilbert, Karakaya, Mert, Wirth, Brunhilde, Fakhro, Khalid A, Tajsharghi, Homa, Bönnemann, Carsten G, Taylor, Jenny C, Houlden, Henry
    Publicado 2021
    “…Vwa1-deficient mice manifest with abnormal peripheral nerve structure/function; however, VWA1 variants have not previously been associated with human disease. By interrogating the genome sequences of 74 180 individuals from the 100K Genomes Project in combination with international gene-matching efforts and targeted sequencing, we identified 17 individuals from 15 families with an autosomal-recessive, non-length dependent, hereditary motor neuropathy and rare biallelic variants in VWA1. …”
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    An ancestral 10-bp repeat expansion in VWA1 causes recessive hereditary motor neuropathy
  3. 691983
    “…C-erbB-2 protein expression in EC tissues was detected by immunohistochemistry. Human EC cell line Eca-109 was purchased from Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. …”
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    Effect of silencing C-erbB-2 on esophageal carcinoma cell biological behaviors by inhibiting IGF-1 pathway activation
  4. 691984
    “…IMPLICATIONS FOR PRACTICE: Palbociclib plus endocrine therapy improves hormone receptor–positive/human epidermal growth factor receptor 2–negative advanced breast cancer outcomes, but is commonly associated with neutropenia. …”
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    Evaluation of the Association of Polymorphisms With Palbociclib‐Induced Neutropenia: Pharmacogenetic Analysis of PALOMA‐2/‐3
  5. 691985
    “…Previous studies of the relationship between p42/44(MAPK) activation and LDLR expression in human hepatoma HepG2-derived cell line showed that that activation of the Raf-1/MEK/p42/44(MAPK) cascade induces LDLR expression and modulation of the Raf-1 kinase signal strength can determine LDLR expression levels. …”
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    Diet-Responsive Hypercholesterolemia With Cardiofaciocutaneous Syndrome Type 3
  6. 691986
    “…BACKGROUND: Trastuzumab emtansine (T-DM1) is a second-line standard therapy for patients with human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer. …”
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    Real-world effectiveness of post-trastuzumab emtansine treatment in patients with HER2-positive, unresectable and/or metastatic breast cancer: a retrospective observational study (KBCSG-TR 1917)
  7. 691987
    por Toor, Jaspreet, Echeverria-Londono, Susy, Li, Xiang, Abbas, Kaja, Carter, Emily D, Clapham, Hannah E, Clark, Andrew, de Villiers, Margaret J, Eilertson, Kirsten, Ferrari, Matthew, Gamkrelidze, Ivane, Hallett, Timothy B, Hinsley, Wes R, Hogan, Daniel, Huber, John H, Jackson, Michael L, Jean, Kevin, Jit, Mark, Karachaliou, Andromachi, Klepac, Petra, Kraay, Alicia, Lessler, Justin, Li, Xi, Lopman, Benjamin A, Mengistu, Tewodaj, Metcalf, C Jessica E, Moore, Sean M, Nayagam, Shevanthi, Papadopoulos, Timos, Perkins, T Alex, Portnoy, Allison, Razavi, Homie, Razavi-Shearer, Devin, Resch, Stephen, Sanderson, Colin, Sweet, Steven, Tam, Yvonne, Tanvir, Hira, Tran Minh, Quan, Trotter, Caroline L, Truelove, Shaun A, Vynnycky, Emilia, Walker, Neff, Winter, Amy, Woodruff, Kim, Ferguson, Neil M, Gaythorpe, Katy AM
    Publicado 2021
    “…We investigate the impact of vaccination activities for Haemophilus influenzae type b, hepatitis B, human papillomavirus, Japanese encephalitis, measles, Neisseria meningitidis serogroup A, rotavirus, rubella, Streptococcus pneumoniae, and yellow fever over the years 2000–2030 across 112 countries. …”
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    Lives saved with vaccination for 10 pathogens across 112 countries in a pre-COVID-19 world
  8. 691988
    “…During the RTN period, 76.6% (108/141) of fallers received human staff assistance in less than 10 minutes, and 55.3% (78/141) of them spent less than 10 minutes on the ground. …”
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    Reduction of Time on the Ground Related to Real-Time Video Detection of Falls in Memory Care Facilities: Observational Study
  9. 691989
    “…The median progression-free survival (PFS) was 7.64 months (95% CI, 6.89–8.40 months, I(2) = 92.3%), and the median overall survival (OS) was 24.51 months (95% CI, 21.25–27.78 months, I(2) = 92.7%). Treatment line, human epidermal growth factor receptor-2(Her-2)-negative status and dosage were found to be sources of heterogeneity among the included studies. …”
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    A systematic review and meta-analysis of nab-paclitaxel mono-chemotherapy for metastatic breast cancer
  10. 691990
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    Diagnosis delayed: health profile differences between women with undiagnosed polycystic ovary syndrome and those with a clinical diagnosis by age 35 years
  11. 691991
    “…SIMPLE SUMMARY: The average human life expectancy is increasing worldwide, which is leading to increases in the proportion of elderly patients (≥80 years) with gastric cancer. …”
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    Impact of Comorbidities, Sarcopenia, and Nutritional Status on the Long-Term Outcomes after Endoscopic Submucosal Dissection for Early Gastric Cancer in Elderly Patients Aged ≥ 80 Years
  12. 691992
    “…Among the plasma proteins that increased in mice with residual rectal tumor after chemoradiation compared to mice that achieved regression, we selected three proteins (Vascular endothelial growth factor receptor 3 [VEGFR3], Insulin like growth factor binding protein 4 [IGFBP4], and Cathepsin B [CTSB]) for validation in human plasma samples. In addition, we explored whether four tissue protein biomarkers previously shown to predict response to nCRT (Epidermal growth factor receptor [EGFR], Ki-67, E-cadherin, and Prostaglandin G/H synthase 2 [COX2]) also act as potential blood biomarkers. …”
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    Identification of Blood-Based Biomarkers for the Prediction of the Response to Neoadjuvant Chemoradiation in Rectal Cancer
  13. 691993
    “…These findings can foster future research in larger animals and human subjects.*p<0.05, **p<0.01. Error bars: Standard Deviations.…”
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    QS6: Collagen-glycosaminoglycans Scaffold Can Improve Muscle Function Recovery After Volumetric Muscle Loss Injury in Rat Model
  14. 691994
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    How do young men want to receive information about fertility? Young men’s attitudes towards a fertility campaign targeting men in Copenhagen, Denmark
  15. 691995
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    Toxic elements in follicular fluid adversely influence the likelihood of pregnancy and live birth in women undergoing IVF
  16. 691996
    “…STUDY QUESTION: Does dual trigger in freeze-all in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles improve the cumulative live-birth outcome compared with human chorionic gonadotropin (hCG) trigger? SUMMARY ANSWER: Dual trigger for final follicular maturation improves the cumulative pregnancy and live-birth rates compared with hCG trigger in freeze-all IVF/ICSI cycles. …”
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    Dual Trigger for Final Follicular Maturation Improves Cumulative Live-Birth Rate in Ovarian Stimulation for Freeze-All In Vitro Fertilization/Intracytoplasmic Sperm Injection Cycles
  17. 691997
    “…In this pilot biomarker study, we report for the first time that miRNA precursor RNAs (pri-miRNAs) are robust and sensitive biomarkers for BC, detectable in both human blood plasma and biopsy tissues. Pri-miRNA detection and quantification do not require a special enrichment procedure, thus reducing specimen quantity. …”
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    Pri-miR526b and Pri-miR655 Are Potential Blood Biomarkers for Breast Cancer
  18. 691998
    “…BACKGROUND: COVID-19 (Coronavirus Disease-2019) has spread widely around the world and impacted human health for millions. The lack of effective targeted drugs and vaccines forces scientific world to search for new effective antiviral therapeutic drugs. …”
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    Effect of dihydromyricetin on SARS-CoV-2 viral replication and pulmonary inflammation and fibrosis
  19. 691999
    “…MAIN OUTCOMES AND MEASURES: The primary outcome was emotional exhaustion and burnout symptoms, which were assessed for 28 days using the emotional exhaustion subscale of the Brazilian version of the Maslach Burnout Inventory–Human Services Survey for Medical Personnel. RESULTS: A total of 120 participants were randomized to receive either CBD, 300 mg, plus standard care (treatment arm; n = 61) or standard care alone (control arm; n = 59) for 28 days. …”
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    Efficacy and Safety of Cannabidiol Plus Standard Care vs Standard Care Alone for the Treatment of Emotional Exhaustion and Burnout Among Frontline Health Care Workers During the COVID-19 Pandemic: A Randomized Clinical Trial
  20. 692000
    por Wu, Baojie, Xi, Shuyi
    Publicado 2021
    “…First, the ONCOMINE and UALCAN databases were used to analyze the mRNA expression of different MCMs. The Human Protein Atlas database was used to analyze the protein expression of MCMs in normal and tumor tissues. …”
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    Bioinformatics analysis of the transcriptional expression of minichromosome maintenance proteins as potential indicators of survival in patients with cervical cancer
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