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692421Increased serine synthesis in cumulus cells of young infertile women with diminished ovarian reservepor Lu, Xinmei, Lv, Xiaolong, Dong, Xi, Li, Yulin, Turathum, Bongkoch, Liu, Suying, Wang, Xuemei, Shi, Huijuan, Liu, YubingEnlace del recurso
Publicado 2023
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692422
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692423por Jin, Aina, Kan, Zhaobo, Tan, Qiushi, Shao, Jing, Han, Qi, Chang, Yashan, An, Nan, Yi, Muqing“…Food-derived oligopeptides, such as rice and soybean peptides, have been shown to directly regulate abnormal lipid metabolism or promote hypolipidemia and fat oxidation in cell culture models, animal models, and human studies. However, whether supplementation with oligopeptides derived from multiple food sources can promote lipid degradation and fat oxidation in athletes remains unclear. …”
Publicado 2023
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692424por Miao, Xin, Wu, Liviawati S., Lin, Shun Xin Wang, Xu, Yan, Chen, Yang, Iwaki, Yuki, Kobos, Rachel, Stephenson, Tara, Kemmerer, Kristy, Uhlar, Clarissa M., Banerjee, Arnob, Goldberg, Jenna D., Trancucci, Danielle, Apte, Amit, Verona, Raluca, Pei, Lixia, Desai, Rachit, Hickey, Kathleen, Su, Yaming, Ouellet, Daniele, Samtani, Mahesh N., Guo, Yue, Garfall, Alfred L., Krishnan, Amrita, Usmani, Saad Z., Zhou, Honghui, Girgis, Suzette“…OBJECTIVE: We report the population pharmacokinetics of teclistamab administered intravenously and subcutaneously (SC) and exposure–response relationships from the phase I/II, first-in-human, open-label, multicenter MajesTEC-1 study. …”
Publicado 2023
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692425por Sun, Ke-Xin, Chen, Yan-Yi, Li, Zhen, Zheng, Shi-Jie, Wan, Wen-Juan, Ji, Yan, Hu, Ke“…AIM: To confirm the effect of genipin, a vital component of GJE fruit, in preventing human retinal microvascular endothelial cells (hRMECs) from AGEs damage in DR, to investigate the effect of genipin in the down-regulation of AGEs expression, and to explore the role of the CHGA/UCP2/glucose transporter 1 (GLUT1) signal pathway in this process. …”
Publicado 2023
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692426por Wang, Yi, Ji, Nan, Zhang, Yang, Chu, Junsheng, Pan, Changcun, Zhang, Peng, Ma, Weiwei, Zhang, Xueguang, Xi, Jianzhong Jeff, Chen, Mingze, Zhang, Yonghui, Zhang, Liwei, Sun, Tao“…This study investigates the therapeutic potential of human Vγ9Vδ2 T cells in GBM treatment. The sensitivity of different glioma specimens to Vγ9Vδ2 T cell-mediated cytotoxicity is assessed using a patient-derived tumor cell clusters (PTCs) model. …”
Publicado 2023
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692427por Lundgren, Christine, Tutzauer, Julia, Church, Sarah E., Stål, Olle, Ekholm, Maria, Forsare, Carina, Nordenskjöld, Bo, Fernö, Mårten, Bendahl, Pär-Ola, Rydén, Lisa“…Associations between GEX signatures and tamoxifen effect were assessed in patients with estrogen receptor-positive/human epidermal growth factor receptor 2-negative (ER+ /HER2−) tumors using Kaplan–Meier estimates and Cox regression. …”
Publicado 2023
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692428por Ferrand, Timothy, Boulant, Justine, He, Chloe, Chambost, Jérôme, Jacques, Céline, Pena, Chris-Alexandre, Hickman, Cristina, Reignier, Arnaud, Fréour, ThomasEnlace del recurso
Publicado 2023
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692429por Curfs, Max H J M, Cohlen, Ben J, Slappendel, Els J, Schoot, Dick C, Derhaag, Josien G, van Golde, Ron J T, van der Heijden, Godfried W, Baart, Esther B, Smeenk, Jesper M J, Ritfeld, Victoria E E G, Brohet, Richard M, van Bavel, Casandra C A WEnlace del recurso
Publicado 2023
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692430por Foss de Freitas, Maria Cristina, DillGomes, Anabela, Neidert, Adam, Podgrabinska, Simona, Olenchock, Ben, SinhaRoy, Rababir, Harris, Charles Andrew, Akinci, Baris, Altarejos, Judith, Oral, Elif A“…This compassionate-use experience represents the longest human exposure to mibavademab. The long-term follow-up supports the safety profile of the treatment. …”
Publicado 2023
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692431“…Ref1. van der Klaauw AA, Farooqi IS et.al. Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance. …”
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692432por Abel, Brent, Minich, Waldemar, Schwiebert, Christian, Welsink, Tim, Seemann, Petra, Schomburg, Lutz, Brown, Rebecca J“…A bridge-assay for InsR-aAb detection was established using recombinant human insulin receptor as bait and detector and validated using monoclonal antibodies as positive controls. …”
Publicado 2023
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692433por Blair, Joanne, Miller, Bradley Scott, Hojby, Michael, Maniatis, Aristides K, Mori, Jun, Boettcher, Volker, Kim, Ho-Seong, Bang, Rikke Beck, Fries Jensen, Lasse De, Polak, Michel, Horikawa, Reiko“…Somapacitan is a long-acting reversible albumin-binding human GH derivative in development for once-weekly s.c. administration in children with GHD. …”
Publicado 2023
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692434por Trotter, Dinko Gonzalez, McGinniss, Jennifer, Economides, Aris N, Mohammadi, Kusha, Rankin, Andrew J, Musser, Bret, Mellis, Scott, Forleo-Neto, Eduardo, Herman, Gary“…FOP is characterized by the deposition of bone in soft tissues known as heterotopic ossification (HO) and episodic painful flare-ups. Garetosmab, a fully human monoclonal antibody against activin-A, is being investigated for the prevention of new HO lesions in patients with FOP. …”
Publicado 2023
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692435por Vidana Gamage, Hashni Epa, Shahoei, Sayyed Hamed, Albright, Samuel, Nguyen, Tiffany, Farmer, Rachel Elizabeth, Weisser, Erin, Bautista Rivas, Rafael Ovidio, Schane, Claire P, Wang, Yu, Nelczyk, Adam, Ma, Liqian, Tiwari, Srishti, Gupta, Anasuya Das, Bendre, Shruti, Apetoh, Lionel, Hergenrother, Paul, Nelson, Erik Russell“…Mice lacking NR0B2 exhibited significantly increased tumor growth and elevated tumor infiltrating T(regs). Additionally, human breast tumors samples indicated an inverse correlation between NR0B2 and FOXP3 (marker for T(regs)). …”
Publicado 2023
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692436por Henes, Melanie, Mann, Ellen, Hirchenhain, Christine, Bauer, Emanuel, Kentner, Alexander, Quaas, Jens, Koßagk, Christopher, Gallwas, Julia, Henes, Leon, Schumacher, Antonia, Küppers, Volkmar“…As a referral diagnosis, HPV persistence (HPV: human papillomavirus) with group I was determined in 23.9% (1139), HPV persistence with group II-a in 2.1% (100), II-p (ASC-US) in 11.2% (535), and II-g (AGC endocervical NOS) in 1.3% (64). …”
Publicado 2023
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692437por Bénard, Élodie, Drolet, Mélanie, Laprise, Jean-François, Gingras, Guillaume, Jit, Mark, Boily, Marie-Claude, Bloem, Paul, Brisson, Marc“…BACKGROUND: Given the accumulating evidence that one-dose vaccination could provide high and sustained protection against human papillomavirus (HPV) infection and related diseases, we examined the population-level effectiveness and efficiency of one-dose HPV vaccination of girls compared with two-dose vaccination, using mathematical modelling. …”
Publicado 2023
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692438Publicado 2023“…OBJECTIVE: Total 25(OH)D (t-25[OH]D), a marker traditionally used in the assessment of vitamin D (VitD) in the human body, includes 25(OH)D(2), 25(OH)D(3), and C(3)-epimers-25(OH)D(3 )(C(3)-epi). …”
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692439por Ikenuma, Hiroshi, Ogata, Aya, Koyama, Hiroko, Ji, Bin, Ishii, Hideki, Yamada, Takashi, Abe, Junichiro, Seki, Chie, Nagai, Yuji, Ichise, Masanori, Minamimoto, Takafumi, Higuchi, Makoto, Zhang, Ming-Rong, Kato, Takashi, Ito, Kengo, Suzuki, Masaaki, Kimura, Yasuyuki“…On autoradiography, radioactivity accumulation was observed for [(11)C]GG502 and decreased by non-radioactive GG502 in the mouse spleen and human brain, indicating the possibility of specific binding of this ligand to RIPK1. …”
Publicado 2023
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692440por YANG, Cheng, SHI, Yanmei, PANG, Tiantian, LIU, Xiaobing, ZHANG, Zhiyu, HU, Kai, ZHANG, Shusheng“…SPME has been successfully applied to the in vivo analysis of target analytes in animal, human, and plant tissues. The coating material plays a significant role in the development of in vivo SPME methods and must meet various analytical requirements, including a suitable geometry for the SPME device, high extraction capacity, excellent selectivity, and wide extraction coverage for the target analytes. …”
Publicado 2023
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