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692821
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692822
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692823por Li, Qiaofeng, Lan, Taijin, He, Songhua, Chen, Weiwei, Li, Xiaolan, Zhang, Weiquan, Liu, Ying, Zhang, Qiuping, Chen, Xin, Han, Yaoyao, Su, Zhiheng, Zhu, Dan, Guo, Hongwei“…Finally, an in vitro assay was performed to investigate the protective effects of potential active compounds against hydrogen peroxide (H(2)O(2)) induced oxidative damage in human umbilical vein endothelial cells (HUVEC). RESULTS: LFG could effectively reduce blood pressure and increase serum NO content in SHR model. …”
Publicado 2021
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692824“…Included dPCR, qPCR, and LAMP studies using any type of human specimens should report the number of true-positive, true-negative, false-positive, and false-negative cases with Emergency Use Authorization (EUA)-approved PCR assays as the comparator. …”
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692825por Robichaud, Sabrina, Fairman, Garrett, Vijithakumar, Viyashini, Mak, Esther, Cook, David P., Pelletier, Alexander R., Huard, Sylvain, Vanderhyden, Barbara C., Figeys, Daniel, Lavallée-Adam, Mathieu, Baetz, Kristin, Ouimet, Mireille“…Abbreviations: ADGRL3: adhesion G protein-coupled receptor L3; agLDL: aggregated low density lipoprotein; AMPK: AMP-activated protein kinase; APOA1: apolipoprotein A1; ATG: autophagy related; AUP1: AUP1 lipid droplet regulating VLDL assembly factor; BMDM: bone-marrow derived macrophages; BNIP3L: BCL2/adenovirus E1B interacting protein 3-like; BSA: bovine serum albumin; CALCOCO2: calcium binding and coiled-coil domain 2; CIRBP: cold inducible RNA binding protein; COLGALT1: collagen beta(1-O)galactosyltransferase 1; CORO1A: coronin 1A; DMA: deletion mutant array; Faa4: long chain fatty acyl-CoA synthetase; FBS: fetal bovine serum; FUS: fused in sarcoma; HMGB1: high mobility group box 1; HMGB2: high mobility group box 2: HSP90AA1: heat shock protein 90: alpha (cytosolic): class A member 1; HSPA5: heat shock protein family A (Hsp70) member 5; HSPA8: heat shock protein 8; HSPB1: heat shock protein 1; HSPH1: heat shock 105kDa/110kDa protein 1; LDAH: lipid droplet associated hydrolase; LIPA: lysosomal acid lipase A; LIR: LC3-interacting region; MACROH2A1: macroH2A.1 histone; MAP1LC3: microtubule-associated protein 1 light chain 3; MCOLN1: mucolipin 1; NBR1: NBR1, autophagy cargo receptor; NPC2: NPC intracellular cholesterol transporter 2; OPTN: optineurin; P/S: penicillin-streptomycin; PLIN2: perilipin 2; PLIN3: perilipin 3; PNPLA2: patatin like phospholipase domain containing 2; RAB: RAB, member RAS oncogene family; RBBP7, retinoblastoma binding protein 7, chromatin remodeling factor; SAR: selective autophagy receptor; SCARB2: scavenger receptor class B, member 2; SGA: synthetic genetic array; SQSTM1: sequestosome 1; TAX1BP1: Tax1 (human T cell leukemia virus type I) binding protein 1; TFEB: transcription factor EB; TOLLIP: toll interacting protein; UBE2G2: ubiquitin conjugating enzyme E2 G2; UVRAG: UV radiation resistance associated gene; VDAC2: voltage dependent anion channel 2; VIM: vimentin…”
Publicado 2021
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692826por Levin, Myron J, Ustianowski, Andrew, De Wit, Stéphane, Launay, Odile, Avila, Miles, Seegobin, Seth, Templeton, Alison, Yuan, Yuan, Ambery, Philip, Arends, Rosalinda H, Beavon, Rohini, Near, Karen A, Padilla, Kelly W, Psachoulia, Konstantina, Sharbaugh, Audrey, Streicher, Katie, Pangalos, Menelas N, Esser, Mark T, Gasser, Robert A“…AZD7442 comprises 2 fully human extended half-life SARS-CoV-2–neutralizing antibodies that bind distinct epitopes of the viral spike protein receptor binding domain. …”
Publicado 2021
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692827por Maas, Brian M, Lommerse, Jos, Plock, Nele, Railkar, Radha, Amy Cheung, S Y, Caro, Luzelena, Chen, Jingxian, Liu, Wen, Zhang, Ying, Huang, Qinlei, Gao, Wei, Qin, Li, Meng, Jie, Witjes, Han, Schindler, Emilie, Guiastrennec, Benjamin, Bellanti, Francesco, Spellman, Daniel, Roadcap, Brad, Kalinova, Mariya, Fok-Seang, Juin, Catchpole, Andrew P, Espeseth, Amy, Aubrey Stoch, S, Lai, Eseng, Vora, Kalpit A, Aliprantis, Antonios O, Sachs, Jeffrey R“…The model was validated using viral challenge experiments in cotton rats and phase 3 RSV-A efficacy results in infants for an anti-RSV F mAb, REGN-2222. A phase 2b human RSV challenge study (HCS) in adults was also conducted with MK-1654. …”
Publicado 2021
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692828por Rankin, Danielle A, Speaker, Andrew, Perez, Ariana, Haddadin, Zaid, Probst, Varvara, Schuster, Jennifer E, Blozinski, Anna L, Rahman, Herdi Kurnia, Stewart, Laura S, Rha, Brian, Michaels, Marian G, Williams, John V, Boom, Julie A, Sahni, Leila C, Allen Staat, Mary, Schlaudecker, Elizabeth P, McNeal, Monica, Selvarangan, Rangaraj, Harrison, Christopher J, Weinberg, Geoffrey A, Szilagyi, Peter G, Englund, Janet A, Klein, Eileen J, McMorrow, Meredith, Patel, Manish, Chappell, James, Midgley, Claire, Halasa, Natasha B, Halasa, Natasha B“…Molecular testing for RV/EV, RSV, influenza, and other respiratory viruses [i.e., human metapneumovirus, parainfluenza virus (Types 1-4), and adenovirus] were performed on specimens collected from children enrolled children. …”
Publicado 2021
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692829por Su, Wen, Walker, Matthew, Rebelo, Maria, Tang, Cong, Coelho, Ana R, Tatalick, Laurie, Riley, Marianne, Yu, Kevin, Blancas-Mejia, Luis M, Silva, Daniel-Adriano, Shoultz, David, Bernardes, Goncalo, Yen, Hui-Ling“…NL-CVX1 further demonstrates the power and utility of de novo protein design for developing proteins as human therapeutics. [Image: see text] Figure 4. NL-CVX1 is effective in preventing clinically significant SARS-CoV-2 viral infection in a K18hACE2 mouse model. …”
Publicado 2021
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692830por Hill-Batorski, Lindsay, Hatta, Yasuko, Moser, Michael, Marshall, David, Bilsel, Pamuk“…Quad M2SR is in late-stage development for testing in a first-in-human clinical study. DISCLOSURES: Lindsay Hill-Batorski, PhD, FluGen (Employee) Yasuko Hatta, DVM, PhD, FluGen (Employee) Michael Moser, PhD, FluGen (Employee) David Marshall, BS, FluGen (Employee) Pamuk Bilsel, PhD, FluGen (Employee)…”
Publicado 2021
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692831por Snyder, Thomas M, Gittelman, Rachel M, Klinger, Mark, May, Damon H, Osborne, Edward J, Taniguchi, Ruth, Jabran Zahid, H, Elyanow, Rebecca, Dalai, Sudeb C, Kaplan, Ian M, Dines, Jennifer N, Noakes, Matthew T, Pandya, Ravi, Baldo, Lance, Semprini, Simona, Cerchione, Claudio, Nicolini, Fabio, Mazza, Massimiliano, Delmonte, Ottavia M, Dobbs, Kerry, Laguna-Goya, Rocio, Carreño-Tarragona, Gonazalo, Barrio, Santiago, Imberti, Luisa, Sottini, Alessandra, Quiros-Roldan, Eugenia, Rossi, Camillo, Biondi, Andrea, Bettini, Laura Rachele, D’Angio, Mariella, Bonfanti, Paolo, Tompkins, Miranda F, Alba, Camille, Dalgard, Clifton, Sambri, Vittorio, Martinelli, Giovanni, Goldman, Jason D, Heath, James R, Su, Helen C, Notarangelo, Luigi D, Paz-Artal, Estela, Martinez-Lopez, Joaquin, Carlson, Jonathan M, Robins, Harlan S“…METHODS: We deeply characterized 116 convalescent COVID-19 subjects by experimentally mapping CD8 and CD4 T-cell responses via antigen stimulation to 545 Human Leukocyte Antigen (HLA) class I and 284 class II viral peptides. …”
Publicado 2021
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692832por Tyrmi, Jaakko S, Arffman, Riikka K, Pujol-Gualdo, Natàlia, Kurra, Venla, Morin-Papunen, Laure, Sliz, Eeva, Piltonen, Terhi T, Laisk, Triin, Kettunen, Johannes, Laivuori, HanneleEnlace del recurso
Publicado 2021
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692833por de Nie, I, Mulder, C L, Meißner, A, Schut, Y, Holleman, E M, van der Sluis, W B, Hannema, S E, den Heijer, M, Huirne, J, van Pelt, A M M, van Mello, N MEnlace del recurso
Publicado 2021
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692834por Zondervan, Krina T, Missmer, Stacey, Abrao, Mauricio S, Einarsson, Jon I, Horne, Andrew W, Johnson, Neil P, Lee, Ted T M, Petrozza, John, Tomassetti, Carla, Vermeulen, Nathalie, Grimbizis, Grigoris, De Wilde, Rudy LeonEnlace del recurso
Publicado 2022
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692835
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692836por Hall, Courtney D., Herdman, Susan J., Whitney, Susan L., Anson, Eric R., Carender, Wendy J., Hoppes, Carrie W., Cass, Stephen P., Christy, Jennifer B., Cohen, Helen S., Fife, Terry D., Furman, Joseph M., Shepard, Neil T., Clendaniel, Richard A., Dishman, J. Donald, Goebel, Joel A., Meldrum, Dara, Ryan, Cynthia, Wallace, Richard L., Woodward, Nakia J.“…Article types included meta-analyses, systematic reviews, randomized controlled trials, cohort studies, case-control series, and case series for human subjects, published in English. Sixty-seven articles were identified as relevant to this clinical practice guideline and critically appraised for level of evidence. …”
Publicado 2022
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692837por Dreyer Holt, Marianne, Warzecha, Agnieszka Katarzyna, Bülow, Nathalie Søderhamn, Skouby, Sven Olaf, Englund, Anne Lis Mikkelsen, Birch Petersen, Kathrine, Macklon, Nicholas StephenEnlace del recurso
Publicado 2022
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692838por Trivieri, Nadia, Visioli, Alberto, Mencarelli, Gandino, Cariglia, Maria Grazia, Marongiu, Laura, Pracella, Riccardo, Giani, Fabrizio, Soriano, Amata Amy, Barile, Chiara, Cajola, Laura, Copetti, Massimiliano, Palumbo, Orazio, Legnani, Federico, DiMeco, Francesco, Gorgoglione, Leonardo, Vescovi, Angelo L., Binda, Elena“…In vivo comparisons were carried out in mouse-human xenografts GBM model by a hierarchical linear model for repeated measurements and Dunnett’s multiple comparison test with the distribution of survival compared by Kaplan–Meier method. …”
Publicado 2022
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692839por Witte, Desiree, Handley, Amanda, Jere, Khuzwayo C, Bogandovic-Sakran, Nada, Mpakiza, Ashley, Turner, Ann, Pavlic, Daniel, Boniface, Karen, Mandolo, Jonathan, Ong, Darren Suryawijaya, Bonnici, Rhian, Justice, Frances, Bar-Zeev, Naor, Iturriza-Gomara, Miren, Ackland, Jim, Donato, Celeste M, Cowley, Daniel, Barnes, Graeme, Cunliffe, Nigel A, Bines, Julie E“…BACKGROUND: Rotavirus vaccines reduce rotavirus-related deaths and hospitalisations but are less effective in high child mortality countries. The human RV3-BB neonatal G3P[6] rotavirus vaccine administered in a neonatal schedule was efficacious in reducing severe rotavirus gastroenteritis in Indonesia but had not yet been evaluated in African infants. …”
Publicado 2022
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692840por Onogi, Sachie, Ezoe, Kenji, Kawasaki, Nami, Hayashi, Hiroko, Kuroda, Tomoko, Takeshima, Kazumi, Tanoue, Kaou, Nishii, Shogo, Kato, KeiichiEnlace del recurso
Publicado 2022
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