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692941“…ACKNOWLEDGEMENTS: Supported by a project grant from the Project of Humanities and Social Sciences Research of Chinese Ministry of Education (Grant No.18JF206).…”
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692942“…ACKNOWLEDGEMENTS: This paper was financially supported by the Research Project of Humanities and Social Sciences in Universities of the Ministry of Education “The Influence Mechanism of Grassroots Micro-corruption on Farmers' Sense of Access and Its Integrated Governance” (Project No.: 19YJC630017); National Natural Science Foundation” The Influence of Government Regulation on the Safe Production Behavior of Agricultural Products in Family Farms — Based on the Survey in Jiangxi Province“ (Project No.: 72064019).…”
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692943por Eyileten, Ceren, Wicik, Zofia, Simões, Sérgio N., Martins-Jr, David C., Klos, Krzysztof, Wlodarczyk, Wojciech, Assinger, Alice, Soldacki, Dariusz, Chcialowski, Andrzej, Siller-Matula, Jolanta M., Postula, Marek“…In this study we identified and validated miRNAs which could serve as novel, thrombosis-related predictive biomarkers of the COVID-19 complications, and can be used for early stratification of patients and prediction of severity of infection development in an individual.Abbreviations: ACE2, angiotensin-converting enzyme 2AF, atrial fibrillationAPP, Amyloid Beta Precursor ProteinaPTT, activated partial thromboplastin timeAUC, Area under the curveAβ, amyloid betaBMI, body mass indexCAD, coronary artery diseaseCALM1, Calmodulin 1 geneCaM, calmodulinCCND1, Cyclin D1CI, confidence intervalCOPD, chronic obstructive pulmonary diseaseCOVID-19, Coronavirus disease 2019CRP, C-reactive proteinCV, CardiovascularCVDs, cardiovascular diseasesDE, differentially expressedDM, diabetes mellitusEGFR, Epithelial growth factor receptorELAVL1, ELAV Like RNA Binding Protein 1FLNA, Filamin AFN1, Fibronectin 1GEO, Gene Expression OmnibushiPSC-CMs, Human induced pluripotent stem cell-derived cardiomyocytesHSP90AA1, Heat Shock Protein 90 Alpha Family Class A Member 1Hsp90α, heat shock protein 90αICU, intensive care unitIL, interleukinIQR, interquartile rangelncRNAs, long non-coding RNAsMI, myocardial infarctionMiRNA, MiR, microRNAmRNA, messenger RNAncRNA, non-coding RNANERI, network-medicine based integrative approachNF-kB, nuclear factor kappa-light-chain-enhancer of activated B cellsNPV, negative predictive valueNXF, nuclear export factorPBMCs, Peripheral blood mononuclear cellsPCT, procalcitoninPPI, Protein-protein interactionsPPV, positive predictive valuePTEN, phosphatase and tensin homologqPCR, quantitative polymerase chain reactionROC, receiver operating characteristicSARS-CoV-2, severe acute respiratory syndrome coronavirus 2SD, standard deviationTLR4, Toll-like receptor 4TM, thrombomodulinTP53, Tumour protein P53UBC, Ubiquitin CWBC, white blood cells…”
Publicado 2022
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692944por Biao, Tang, Cai-feng, He, Xiao-hong, Lu, Xiao-li, Chang, Wen-bei, Liu, Jun, Wang, Chao, Ci, Tao, Yuan“…These proteins were mainly involved in multiple pathways, including Focal adhesion, ECM-receptor interaction, Human papillomavirus infection, PI3K-Akt signaling pathway, PPAR signaling pathway, AMPK signaling pathway and others. …”
Publicado 2022
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692945por Gianaroli, Luca, Veiga, Anna, Gordts, Stephan, Ebner, Thomas, Woodward, Bryan, Plas, Catherine, van Groesen, Wil, Sgargi, Serena, Kovačič, BorutEnlace del recurso
Publicado 2022
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692946
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692947por Baisley, Kathy, Kemp, Troy J, Kreimer, Aimée R, Basu, Partha, Changalucha, John, Hildesheim, Allan, Porras, Carolina, Whitworth, Hilary, Herrero, Rolando, Lacey, Charles J, Schiller, John T, Lucas, Eric, Mutani, Paul, Dillner, Joakim, Indangasi, Jackton, Muwonge, Richard, Hayes, Richard J, Pinto, Ligia A, Watson-Jones, Deborah“…BACKGROUND: Human papillomavirus (HPV) vaccines are given as a two-dose schedule in children aged 9–14 years, or as three doses in older individuals. …”
Publicado 2022
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692948por Talbot, Anna L, Alexopoulou, Evaggelia, Kallemose, Thomas, Freiesleben, Nina la Cour, Nielsen, Henriette S, Zedeler, AnneEnlace del recurso
Publicado 2022
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692949por Wessel, J A, Mochtar, M H, Besselink, D E, Betjes, H, de Bruin, J P, Cantineau, A E P, Groenewoud, E R, Hooker, A B, Lambalk, C B, Kwee, J, Kaaijk, E M, Louwé, L A, Maas, J W M, Mol, B W J, van Rumste, M M E, Traas, M A F, Goddijn, M, van Wely, M, Mol, FEnlace del recurso
Publicado 2022
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692950por Eckburg, Paul B, Clarke, Dave, Long, Jennifer, Chanda, Sanjay, Krause, Kevin M, Easom, Eric, Talbot, George, Rubino, Christopher M, Molga, Angela“…Standard Ph1 clinical and laboratory evaluations and treatment-emergent adverse events (TEAEs) were assessed. Based on prior human studies using significantly higher EBO daily doses, gastrointestinal (GI) events and anemia were predetermined AEs of special interest (AESIs). …”
Publicado 2022
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692951por Blázquez-Bondia, Carlos, Parera, Mariona, Català-Moll, Francesc, Casadellà, Maria, Elizalde-Torrent, Aleix, Aguiló, Meritxell, Espadaler-Mazo, Jordi, Santos, José Ramon, Paredes, Roger, Noguera-Julian, Marc“…BACKGROUND: Some HIV-1 infected patients are unable to completely recover normal CD4+ T-cell (CD4+) counts after achieving HIV-1 suppression with combined Antiretroviral Therapy (cART), hence being classified as immuno-discordant. The human microbiome plays a crucial role in maintaining immune homeostasis and is a potential target towards immune reconstitution. …”
Publicado 2022
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692952por Gameiro, Sofia, Armstrong, Kiri, Carluke, Natasha, Baccino, Giuliana, Zegers-Hochschild, Fernando, Boivin, JackyEnlace del recurso
Publicado 2022
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692953por Bredenoord, A J, Dellon, E S, Lucendo, A J, Collins, M H, Khodzhayev, A, Sun, X, Patel, K, Beazley, B, Shabbir, A“…Dupilumab (DPL), a fully human monoclonal antibody, blocks the shared receptor component for IL-4/IL-13, key and central drivers of type 2 inflammation. …”
Publicado 2023
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692954“…In a phase 2 trial, anifrolumab, a human monoclonal antibody to type I interferon receptor subunit 1, suppressed interferon gene signatures and substantially reduced SLE disease activity. …”
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692955por Liisborg, Charlotte“…From this knowledge, a “Human inflammation model” has been developed. Since then, the MPNs has been used as model diseases for a similar inflammation model for the development of Alzheimer's disease. …”
Publicado 2022
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692956por Crous, P.W., Wingfield, M.J., Burgess, T.I., Hardy, G.E.St.J., Crane, C., Barrett, S., Cano-Lira, J.F., Le Roux, J.J., Thangavel, R., Guarro, J., Stchigel, A.M., Martín, M.P., Alfredo, D.S., Barber, P.A., Barreto, R.W., Baseia, I.G., Cano-Canals, J., Cheewangkoon, R., Ferreira, R.J., Gené, J., Lechat, C., Moreno, G., Roets, F., Shivas, R.G., Sousa, J.O., Tan, Y.P., Wiederhold, N.P., Abell, S.E., Accioly, T., Albizu, J.L., Alves, J.L., Antoniolli, Z.I., Aplin, N., Araújo, J., Arzanlou, M., Bezerra, J.D.P., Bouchara, J.-P., Carlavilla, J.R., Castillo, A., Castroagudín, V.L., Ceresini, P.C., Claridge, G.F., Coelho, G., Coimbra, V.R.M., Costa, L.A., da Cunha, K.C., da Silva, S.S., Daniel, R., de Beer, Z.W., Dueñas, M., Edwards, J., Enwistle, P., Fiuza, P.O., Fournier, J., García, D., Gibertoni, T.B., Giraud, S., Guevara-Suarez, M., Gusmão, L.F.P., Haituk, S., Heykoop, M., Hirooka, Y., Hofmann, T.A., Houbraken, J., Hughes, D.P., Kautmanová, I., Koppel, O., Koukol, O., Larsson, E., Latha, K.P.D., Lee, D.H., Lisboa, D.O., Lisboa, W.S., López-Villalba, Á., Maciel, J.L.N., Manimohan, P., Manjón, J.L., Marincowitz, S., Marney, T.S., Meijer, M., Miller, A.N., Olariaga, I., Paiva, L.M., Piepenbring, M., Poveda-Molero, J.C., Raj, K.N.A., Raja, H.A., Rougeron, A., Salcedo, I., Samadi, R., Santos, T.A.B., Scarlett, K., Seifert, K.A., Shuttleworth, L.A., Silva, G.A., Silva, M., Siqueira, J.P.Z., Souza-Motta, C.M., Stephenson, S.L., Sutton, D.A., Tamakeaw, N., Telleria, M.T., Valenzuela-Lopez, N., Viljoen, A., Visagie, C.M., Vizzini, A., Wartchow, F., Wingfield, B.D., Yurchenko, E., Zamora, J.C., Groenewald, J.Z.“…Neoscolecobasidium gen. nov.) on Agapanthus sp., Polyscytalum purgamentum on leaf litter, Pseudopithomyces diversisporus from human toenail, Saksenaea trapezispora from knee wound of a soldier, and Sirococcus quercus from Quercus sp. …”
Publicado 2016
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692957por Uiterwijk, J W E“…It can also be used to reduce human confirmation of secondary vertices by applying it to data taken over the full emulsion thickness. …”
Publicado 2007
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692958por Parra Ortiz, Ángel Luis“…That is the problem itself, which forces us to point out what are the setbacks of keeping two appeals in force, or duality of ways of challenging, making a proposal for a solution to this conflict for the good of the appellant himself and respect for human rights. of access to justice. Fuentes de consulta: Báez, J. (2022). …”
Publicado 2022
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692959por Duval, A, Nogueira, D, Dissler, N, Maskani Filali, M, Delestro Matos, F, Chansel-Debordeaux, L, Ferrer-Buitrago, M, Ferrer, E, Antequera, V, Ruiz-Jorro, M, Papaxanthos, A, Ouchchane, H, Keppi, B, Prima, P-Y, Regnier-Vigouroux, G, Trebesses, L, Geoffroy-Siraudin, C, Zaragoza, S, Scalici, E, Sanguinet, P, Cassagnard, N, Ozanon, C, De La Fuente, A, Gómez, E, Gervoise Boyer, M, Boyer, P, Ricciarelli, E, Pollet-Villard, X, Boussommier-Calleja, AEnlace del recurso
Publicado 2023
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692960por Corominas, Júlia, Garriga, Carme, Prenafeta, Antoni, Moros, Alexandra, Cañete, Manuel, Barreiro, Antonio, González-González, Luis, Madrenas, Laia, Güell, Irina, Clotet, Bonaventura, Izquierdo-Useros, Nuria, Raïch-Regué, Dàlia, Gallemí, Marçal, Blanco, Julià, Pradenas, Edwards, Trinité, Benjamin, Prado, Julia G., Blanch-Lombarte, Oscar, Pérez-Caballero, Raúl, Plana, Montserrat, Esteban, Ignasi, Pastor-Quiñones, Carmen, Núñez-Costa, Xavier, Taleb, Rachel Abu, McSkimming, Paula, Soriano, Alex, Nava, Jocelyn, Anagua, Jesse Omar, Ramos, Rafel, Lluch, Ruth Martí, Comes, Aida Corpes, Romero, Susana Otero, Gomez, Xavier Martinez, Sans-Pola, Carla, Moltó, José, Benet, Susana, Bailón, Lucía, Arribas, Jose R., Borobia, Alberto M., Parada, Javier Queiruga, Navarro-Pérez, Jorge, Forner Giner, Maria José, Lucas, Rafael Ortí, Jiménez, María del Mar Vázquez, Compán, Salvador Oña, Alvarez-Mon, Melchor, Troncoso, Daniel, Arana-Arri, Eunate, Meijide, Susana, Imaz-Ayo, Natale, García, Patricia Muñoz, de la Villa Martínez, Sofía, Fernández, Sara Rodríguez, Prat, Teresa, Torroella, Èlia, Ferrer, Laura“…BACKGROUND: A SARS-CoV-2 protein-based heterodimer vaccine, PHH-1V, has been shown to be safe and well-tolerated in healthy young adults in a first-in-human, Phase I/IIa study dose-escalation trial. Here, we report the interim results of the Phase IIb HH-2, where the immunogenicity and safety of a heterologous booster with PHH-1V is assessed versus a homologous booster with BNT162b2 at 14, 28 and 98 days after vaccine administration. …”
Publicado 2023
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