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181por Fomchenko, Elena I., Erson-Omay, E. Zeynep, Zhao, Amy, Bindra, Ranjit S., Huttner, Anita, Fulbright, Robert K., Moliterno, Jennifer“…Here, we describe a missense DNMT3A p.P904S mutation in an IDH1-mutant glioblastoma. Although never previously reported in gliomas, this mutation is predicted to be pathogenic and has been reported in several other malignancies. …”
Publicado 2019
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182por Kesler, Shelli R., Harrison, Rebecca A., Petersen, Melissa L., Rao, Vikram, Dyson, Hannah, Alfaro-Munoz, Kristin, Weathers, Shiao-Pei, de Groot, John“…Mutation of the isocitrate dehydrogenase (IDH) gene confers significant benefits in terms of survival and quality of life. …”
Publicado 2019
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183por Liu, Yu-Qing, Wu, Fan, Li, Jing-Jun, Li, Yang-Fang, Liu, Xing, Wang, Zheng, Chai, Rui-Chao“…This study refined the current classification system of IDH-wildtype GBM and may provide a novel perspective for the research and individual therapy of IDH-wildtype GBM.…”
Publicado 2019
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184por Li, Luyuan, Hu, Xiaoyu, Eid, Josiane E., Rosenberg, Andrew E., Wilky, Breelyn A., Ban, Yuguang, Sun, Xiaodian, Galoian, Karina, DeSalvo, Joanna, Yue, Jinbo, Chen, Xi Steven, Blonska, Marzenna, Trent, Jonathan C.“…In this study, we knocked out mutant IDH1 (IDH1(mut)) in two chondrosarcoma cell lines using the CRISPR/Cas9 system. …”
Publicado 2020
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185por Petiti, Jessica, Rosso, Valentina, Croce, Eleonora, Franceschi, Vanessa, Andreani, Giacomo, Dragani, Matteo, De Gobbi, Marco, Lunghi, Monia, Saglio, Giuseppe, Fava, Carmen, Lo Iacono, Marco, Cilloni, Daniela“…Background: Acute myeloid leukemia is a heterogeneous hematological disease, characterized by karyotypic and molecular alterations. Mutations in IDH2 have a role in diagnosis and as a minimal residue disease marker. …”
Publicado 2020
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186por Yoon, Seon-Jin, Park, Junseong, Kim, Hyun Jung, Lee, Joo Ho, Hee Chang, Jong, Ho Lee, Jeong, Kang, Seok-Gu“…Treatment of Glioblastoma (GBM), IDH-wildtype is a history of sequential failure. …”
Publicado 2019
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187por Richardson, Leland G., Nieman, Linda T., Stemmer-Rachamimov, Anat O., Zheng, Xijin S., Stafford, Khalifa, Nagashima, Hiroaki, Miller, Julie J., Kiyokawa, Juri, Ting, David T., Wakimoto, Hiroaki, Cahill, Daniel P., Choi, Bryan D., Curry, William T.“…The metabolic gene isocitrate dehydrogenase 1 (IDH1) is commonly mutated in lower grade glioma (LGG) and secondary glioblastoma (GBM). …”
Publicado 2020
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188por Makarevic, Anastasia, Rapp, Carmen, Dettling, Steffen, Reuss, David, Jungk, Christine, Abdollahi, Amir, von Deimling, Andreas, Unterberg, Andreas, Herold-Mende, Christel, Warta, Rolf“…Here, we analyzed T-cell infiltration and, therefore, a major prerequisite for successful immunotherapy in a series of primary (n = 78) and recurrent (n = 66) isocitrate dehydrogenase (IDH)-mutant glioma and their changes following treatment with radio- and/or chemotherapy. …”
Publicado 2020
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189por Dowdy, Tyrone, Zhang, Lumin, Celiku, Orieta, Movva, Sriya, Lita, Adrian, Ruiz-Rodado, Victor, Gilbert, Mark R., Larion, Mioara“…SIMPLE SUMMARY: The presence of the IDH mutation in glioma raises the possibility that these CNS malignancies could be targeted with metabolic-based therapeutics, however, the exploration of the role that regulatory lipids, such as sphingolipids serve within the IDH1(mut) gliomas remains limited. …”
Publicado 2020
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190por Tran, Paul M. H., Tran, Lynn K. H., Nechtman, John, dos Santos, Bruno, Purohit, Sharad, Satter, Khaled Bin, Dun, Boying, Kolhe, Ravindra, Sharma, Suash, Bollag, Roni, She, Jin-XiongEnlace del recurso
Publicado 2020
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191por Salati, Massimiliano, Caputo, Francesco, Baldessari, Cinzia, Galassi, Barbara, Grossi, Francesco, Dominici, Massimo, Ghidini, Michele“…In this review article, we will focus on the IDH1/IDH2 pathway, discussing the preclinical rationale of its targeting as well as the promises and challenges of the clinical development of IDH inhibitors in biliary tract cancers.…”
Publicado 2020
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192por Cameron, James M., Conn, Justin J. A., Rinaldi, Christopher, Sala, Alexandra, Brennan, Paul M., Jenkinson, Michael D., Caldwell, Helen, Cinque, Gianfelice, Syed, Khaja, Butler, Holly J., Hegarty, Mark G., Palmer, David S., Baker, Matthew J.“…The isocitrate dehydrogenase 1 (IDH1) mutation is associated with improved prognosis, compared to patients with IDH1-wildtype lesions of the same stage. …”
Publicado 2020
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193por Lita, Adrian, Pliss, Artem, Kuzmin, Andrey, Yamasaki, Tomohiro, Zhang, Lumin, Dowdy, Tyrone, Burks, Christina, de Val, Natalia, Celiku, Orieta, Ruiz-Rodado, Victor, Nicoli, Elena-Raluca, Kruhlak, Michael, Andresson, Thorkell, Das, Sudipto, Yang, Chunzhang, Schmitt, Rebecca, Herold-Mende, Christel, Gilbert, Mark R., Prasad, Paras N., Larion, Mioara“…Amongst all gliomas, those harboring a mutation in isocitrate dehydrogenase 1 mutation (IDH1(mut)) acquire a different tumor biology and clinical manifestation from those that are IDH1(WT). …”
Publicado 2021
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194por Pathmanapan, Sinthu, Ilkayeva, Olga, Martin, John T., Loe, Adrian Kwan Ho, Zhang, Hongyuan, Zhang, Guo-Fang, Newgard, Christopher B., Wunder, Jay S., Alman, Benjamin A.“…BACKGROUND: Majority of chondrosarcomas are associated with a number of genetic alterations, including somatic mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 genes, but the downstream effects of these mutated enzymes on cellular metabolism and tumor energetics are unknown. …”
Publicado 2021
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195por Rajani, Karishma, Carlstrom, Lucas, Jacobs, Joshua, Schroeder, Mark, Olson, Ian, Hainy, Matthew, Oh, Juhee, Elmquist, William, Sarkaria, Jann, Burns, Terry“…Scientific advancements are lacking in developing effective therapies for both primary GBM, as well as secondary GBMs, that typically originate as malignant transformation of lower-grade isocitrate dehydrogenase (IDH) 1-mutant tumors. The unique metabolomic profile of IDH1-mutant tumors presents opportunities to develop biomarker signatures of therapeutic efficacy. …”
Publicado 2021
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196por Platten, Michael, Bunse, Lukas, Wick, Antje, Bunse, Theresa, Le Cornet, Lucian, Harting, Inga, Sahm, Felix, Sanghvi, Khwab, Tan, Chin Leng, Poschke, Isabel, Green, Edward, Justesen, Sune, Behrens, Geoffrey A., Breckwoldt, Michael O., Freitag, Angelika, Rother, Lisa-Marie, Schmitt, Anita, Schnell, Oliver, Hense, Jörg, Misch, Martin, Krex, Dietmar, Stevanovic, Stefan, Tabatabai, Ghazaleh, Steinbach, Joachim P., Bendszus, Martin, von Deimling, Andreas, Schmitt, Michael, Wick, Wolfgang“…Mutated isocitrate dehydrogenase 1 (IDH1) defines a molecularly distinct subtype of diffuse glioma(1–3). …”
Publicado 2021
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197“…Isocitrate dehydrogenase (IDH) is a key metabolic enzyme catalyzing the interconversion of isocitrate to α-ketoglutarate (α-KG). …”
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198por Manikis, Georgios C., Ioannidis, Georgios S., Siakallis, Loizos, Nikiforaki, Katerina, Iv, Michael, Vozlic, Diana, Surlan-Popovic, Katarina, Wintermark, Max, Bisdas, Sotirios, Marias, Kostas“…SIMPLE SUMMARY: Significant efforts have been put toward developing MRI-based radiogenomics for IDH status subtyping predictions; however, in the vast majority of these approaches, the external validation sets are absent. …”
Publicado 2021
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199por Sciortino, Tommaso, Secoli, Riccardo, d’Amico, Ester, Moccia, Sara, Conti Nibali, Marco, Gay, Lorenzo, Rossi, Marco, Pecco, Nicolò, Castellano, Antonella, De Momi, Elena, Fernandes, Bethania, Riva, Marco, Bello, Lorenzo“…SIMPLE SUMMARY: Isocitrate dehydrogenase (IDH) mutation is one of the most important prognostic markers in glioma tumors. …”
Publicado 2021
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200“…METHODS: Six cultured patient-derived glioma cell lines, IDH1(wt) (n = 3) and IDH1(mut) (n = 3), were treated with an FDA-approved HDAC inhibitor, panobinostat. …”
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